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1.  Deciphering the role of RNA-binding proteins in the post-transcriptional control of gene expression 
Briefings in Functional Genomics  2010;9(5-6):391-404.
Eukaryotic cells express a large variety of ribonucleic acid-(RNA)-binding proteins (RBPs) with diverse affinity and specificity towards target RNAs that play a crucial role in almost every aspect of RNA metabolism. In addition, specific domains in RBPs impart catalytic activity or mediate protein–protein interactions, making RBPs versatile regulators of gene expression. In this review, we elaborate on recent experimental and computational approaches that have increased our understanding of RNA–protein interactions and their role in cellular function. We review aspects of gene expression that are modulated post-transcriptionally by RBPs, namely the stability of polymerase II-derived mRNA transcripts and their rate of translation into proteins. We further highlight the extensive regulatory networks of RBPs that implement a combinatorial control of gene expression. Taking cues from the recent development in the field, we argue that understanding spatio-temporal RNA–protein association on a transcriptome level will provide invaluable and unexpected insights into the regulatory codes that define growth, differentiation and disease.
doi:10.1093/bfgp/elq028
PMCID: PMC3080770  PMID: 21127008
RNA-binding proteins; RNA-binding domains; RBP–RNA interaction; RBP regulatory networks; RBP target identification

Results 1-1 (1)