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1.  From components to regulatory motifs in signalling networks 
The developments in biochemistry and molecular biology over the past 30 years have produced an impressive parts list of cellular components. It has become increasingly clear that we need to understand how components come together to form systems. One area where this approach has been growing is cell signalling research. Here, instead of focusing on individual or small groups of signalling proteins, researchers are now using a more holistic perspective. This approach attempts to view how many components are working together in concert to process information and to orchestrate cellular phenotypic changes. Additionally, the advancements in experimental techniques to measure and visualize many cellular components at once gradually grow in diversity and accuracy. The multivariate data, produced by experiments, introduce new and exciting challenges for computational biologists, who develop models of cellular systems made up of interacting cellular components. The integration of high-throughput experimental results and information from legacy literature is expected to produce computational models that would rapidly enhance our understanding of the detail workings of mammalian cells.
PMCID: PMC3035204  PMID: 16769680
cell signalling; systems biology; network analysis; biochemical networks; graph theory
Ribonucleic acids (RNAs) are continuing to attract increased attention as they are found to play pivotal roles in biological system. Just as genomics and proteomics have been enabled by the development of effective analytical techniques and instrumentation, the large-scale analysis of non-protein coding (nc)RNAs will benefit as new analytical methodologies are developed which are appropriate to RNA analysis. Mass spectrometry offers a number of advantageous for RNA analysis arising from its ability to provide mass and sequence information starting with limited amounts of sample. This Briefings will highlight recent developments in the field that enable the characterization of RNA modification status, RNA tertiary structures, and ncRNA expression levels. These developments will also be placed in perspective of how mass spectrometry of RNAs can help elucidate the link between the genome and proteome.
PMCID: PMC2442014  PMID: 16769684
Ribonucleic acid; posttranscriptional modifications; Quantitation; mass spectrometry

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