Search tips
Search criteria

Results 1-1 (1)

Clipboard (0)
Year of Publication
Document Types
1.  Evolutionary Conservation of the Signaling Proteins Upstream of Cyclic AMP-Dependent Kinase and Protein Kinase C in Gastropod Mollusks 
Brain, Behavior and Evolution  2009;74(3):191-205.
The protein kinase C (PKC) and the cAMP-dependent kinase (protein kinase A; PKA) pathways are known to play important roles in behavioral plasticity and learning in the nervous systems of a wide variety of species across phyla. We briefly review the members of the PKC and PKA family and focus on the evolution of the immediate upstream activators of PKC and PKA i.e., phospholipase C (PLC) and adenylyl cyclase (AC), and their conservation in gastropod mollusks, taking advantage of the recent assembly of the Aplysia californica and Lottia gigantea genomes. The diversity of PLC and AC family members present in mollusks suggests a multitude of possible mechanisms to activate PKA and PKC; we briefly discuss the relevance of these pathways to the known physiological activation of these kinases in Aplysia neurons during plasticity and learning. These multiple mechanisms of activation provide the gastropod nervous system with tremendous flexibility for implementing neuromodulatory responses to both neuronal activity and extracellular signals.
PMCID: PMC2855279  PMID: 20029183
Phospholipase C; Adenylate cyclase; Signal transduction; Learning and memory; Serotonin; Synaptic plasticity; Protein kinase A; Aplysia

Results 1-1 (1)