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1.  Minimum inhibitory concentrations of penicillin and minocycline for 300 isolates of N. gonorrhoeae. 
The minimum inhibitory concentrations of penicillin and minocycline were measured on 300 consecutive isolates of N. gonorrhoeae from patients attending the Nottingham treatment centre. 210 (70 per cent.) of these were fully sensitive to penicillin (MIC less than 0-1 mug./ml) and 89 per cent. were fully sensitive to minocycline (MIC less than 0-5 mug./ml.). Of the nine strains resistant to penicillin (MIC less than or equal to 0-5 mug./ml.), eight were also of reduced sensitivity to minocycline.
PMCID: PMC1046561  PMID: 808250
2.  Possible inhibition of N. gonnorrhoeae by C. albicans. A clinical study. 
A probably sifnificant difference (p smaller that 0.05) in the occurrence of gonorrhoea was found between women with and without concomitant C. albicans infection. Although this difference could support the recently reported inhibitory effect by C. albicans on N. gonorrhoeae in vitro another explanation might be the possibility that too many women with vaginal candidiasis and no risk for a gonococcal infection were included in the material. There was nothing to support the in vivo effect of C. albicans on N. gonorrhoeae as negative gonococcal cultures in women known to have been exposed to N. gonorrhoeae could not be correlated with the presence of C. albicans. Until the clinical importance of the inhibitory factor of C. albicans has been studied further, the clinician has to be aware of the possibility of false negative gonococcal cultures from women with vaginal candidiasis.
PMCID: PMC1045146  PMID: 806326
4.  Cervical cytology in genital infection. 
Papanicolaou-stained cervical smears taken from 203 female patients with either gonorrhoea, trichomoniasis, or candidosis were examined for the degree of inflammatory change. The results from these patients were compared with the results of smears taken from women who had no evidence of sexually-acquired infection after full assessment in the clinic. Gonorrhoea and trichomoniasis were associated with inflammatory changes but these were less marked in patients with candidosis. It is concluded that, before cytological inflammatory changes are attributed to non-specific genital infection, it is important to exclude gonorrhoea, trichomoniasis, and, to a lesser extent, candidosis.
PMCID: PMC1045173  PMID: 1201458
5.  Effect of spectinomycin on T. pallidum in incubating experimental syphilis. 
Animal experiments were performed to determine if a single-dose treatment for acute gonorrhoea with 2 g. spectinomycin could cure a simultaneously acquired syphilis at a very early stage of incubation. 300 treponemes (Nichols stain T. pallidum) were inoculated intratesticularly and 3 days later spectinomycin was administered in a dose which produced spectinomycin serum levels similar to those in patients who had received a single oral dose of 2 g. This dosage of spectinomycin did not prevent the development of syphilitic orchitis or reactivity to the FTA-ABS test, but it prolonged the subclinical incubation period.
PMCID: PMC1045166  PMID: 127646
8.  Letter: Genito-urinary medicine. 
PMCID: PMC1045193  PMID: 1243672
9.  Tabes dorsalis with sudden onset of paraplegia. 
A case is presented of tabes dorsalis with spinal gumma producing collapse of the L5 vertebra followed by paraplegia.
PMCID: PMC1045179  PMID: 1201461
10.  Leucomelanoderma in early syphilis. 
PMCID: PMC1045178  PMID: 1201460
11.  Editorial 
PMCID: PMC1045163
14.  Book Reviews 
PMCID: PMC1045158
17.  Abstracts 
PMCID: PMC1045138
21.  Letter: Epicillin in gonorrhoea. 
PMCID: PMC1045134  PMID: 1169099
22.  Syphilitic myositis. 
A case of myositis associated with secondary syphilis is described. Complete recovery occurred after antisyphilitic treatment.
PMCID: PMC1045133  PMID: 1131681
23.  Donovanosis (granuloma inguinale) of the oral cavity. 
A female patient suffering from donovanosis of the oral cavity without associated lesions elsewhere is reported. The importance of remembering donovanosis in the differential diagnosis of chronic granulomatous ulceration of the mouth is emphasized.
PMCID: PMC1045131  PMID: 165863
24.  Schistosomiasis of the urinary bladder. A case report. 
The case is reported of a man with schistosomiasis of the bladder which gave rise to non-gonococcal urethritis. Diagnosis was confirmed by finding the characteristic terminal-spined Schistosoma haematobium ova in the urine deposit. The cystoscopic appearances further confirmed the disease and its stage. The patient responded satisfactorily to treatment although the follow-up period was short.
PMCID: PMC1045130  PMID: 1131679
25.  Single-dose treatment of uncomplicated gonorrhoea in males with minocycline. 
Minocycline in a single 300 mg. oral dose was given to 103 men with uncomplicated gonorrhoea, of whom 85 were followed-up for at least 2 weeks. The cure rate in the 85 followed was 94.1 per cent. There were no side-effects. Thus minocycline could be considered as an effective and safe alternative to penicillin in the single-dose treatment of uncomplicated gonorrhoea in the male, but at the moment it is too expensive for routine use.
PMCID: PMC1045121  PMID: 1093637

Results 1-25 (109)