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4.  Sensitivity to penicillin of gonococci in different racial groups. 
The distribution of the sensitivity to penicillin of gonococci isolated from 631 men and 290 women was analysed in relation to the racial origin of the patients and the type of source contact alleged by the men. No difference in the sensitivity patterns was found between strains from white patients from the United Kingdom and those from immigrants from the Caribbean area. Asian men harboured significantly more insensitive strains than men of other racial groups. Men of Caribbean stock who had been born in this country had significantly more infections due to fully sensitive strains. The reasons for these variations are not known, but one contributory factor may be differences within the racial groups in the proportions of infections contracted from prostitutes.
PMCID: PMC1045812  PMID: 6775770
5.  A study of yaws among pygmies in Cameroon and Zaire. 
In a survey of 333 pygmies in the Cameroon 4.5 percent. were found to have clinical evidence of yaws. This was also found in 10 per cent. of the inhabitants of camps in Zaire. The results of VDRL and FTA-ABS tests on a sample of the population are presented. These provide evidence of a very high incidence of treponemal disease, 80 to 90 percent. of the population showing serological evidence of infection. Active transmission is taking place in both areas but more frequently in Zaire.
PMCID: PMC1045144  PMID: 1095143
12.  IgM-FTA test in syphilis in adults. Its relation to clinical findings. 
IgM-FTA tests have been carried out on 209 sera from 169 patients with treated or untreated syphilis at various stages and on 128 sera from 109 patients, born in areas where yaws is or was prevalent, with treated or untreated latent treponemal disease. IgM anti-treponemal antibody was found in virtually all cases of untreated early or early latent syphilis but in only 23 per cent. of sera from patients with untreated late latent syphilis. After treatment the antibody usually disappeared within one year, but it persisted in a minority of patients, including some treated for late symptomatic or congenital syphilis. Except in isolated cases there was no clinical evidence to suggest continued disease activity, although a third of the patient in whom the antibody persisted for more than 2 years after treatment were noted to be homosexuals. The test may assist in differentiating untreated early latent from late latent syphilis.
PMCID: PMC1045269  PMID: 786436
13.  Sensitivity of Neisseria gonorrhoeae to antibiotics in London (1976-78). 
Three surveys of the sensitivity of pretreatment isolates of gonococci to penicillin, ampicillin, tetracycline, spectinomycin, streptomycin, and co-trimoxazole were carried out during the period 1976-78. Compared with the results of previous surveys in the London area the decline in the proportion of strains of gonococci which are insensitive to penicillin appears to have halted. No changes were found in the levels of resistance to ampicillin, tetracycline, or spectinomycin during the period surveyed, although there was a slight increase in the proportion of strains requiring concentrations of 20 microgram spectinomycin per ml for inhibition. Streptomycin resistance has decreased considerably and 91% of strains are now sensitive to 10 microgram streptomycin per ml.
PMCID: PMC1045672  PMID: 159746
14.  Indirect fluorescence test for the detection of anti-gonoccocal antibodies. 
(1) An indirect fluorescence test for the detection of anti-gonococcal antibody is described. (2) Positive results at a serum dilution of 1 in 16 or above were obtained with sera from 20 per cent. of males and 61 per cent. of females with bacteriologically proven gonorrhoea. 3-8 per cent. of presumed false positive results were given by sera from patients presumed not to have gonorrhoea. (3) In different groups of sera, tests for IgM anti-gonococcal antibody were positive in 32 per cent. of those from males but in only 43 per cent. of those from females with positive cultures.
PMCID: PMC1045104  PMID: 804958

Results 1-17 (17)