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1.  Some factors affecting the incubation period and duration of symptoms of urethritis in men. 
In a retrospective study of clinic records containing accurate information on the dates of infection and onset of symptoms, the mean (+/- SEM) incubation period of gonorrhea in men was 6.2 +/- 3.8 days and the mean duration of symptoms (3.1 +/- 2.3 days. For non-specific urethritis the mean (+/- SEM) figures were 7.7 +/- 4.1 and 4.0 +/- 3.4 days respectively; both were significantly longer than for gonorrhoea. Patients with a first episode of urethritis had longer than average incubation periods and duration of symptoms. Past experience of urethritis shortened the duration of symptoms; this was more significant in gonorrhoeae than in non-specific urethritis. "Anxious" men who had attended previously of their own accord when no abnormality had been found had the shortest times. The most notable factor in determining the interval between infection and attendance, however, was whether or not the sexual contact was known. Infections by known contacts were associated with prolonged duration of symptoms which negated the benefit of past experience and, to some extent, of anxiety. Thus, patients should be made more generally aware that known contacts may be a source of infection, especially after a break in a relationship, and that they should return to the clinic as soon as symptoms develop. Furthermore, doctors should examine carefully even the most persistently "neurotic" patients, because they may eventually become infected.
PMCID: PMC1046042  PMID: 7082980
2.  Problem-orientated categorisation of "other conditions" seen in a genitourinary medicine clinic. 
The case sheets of patients coded as D2 (other conditions requiring treatment) and D3 (other conditions not requiring treatment) in 1981 were reclassified on a problem-orientated basis. Ten discreet categories were delineated with ease. Women with non-specific vaginitis and men with Gardnerella vaginalis urogenital infection, usually coded D2 or C4, should be reclassified under the C group of conditions as, for example, "Gardnerella or other bacterial genital infections." It is suggested that codes D2 and D3 be replaced by the following nine categories: genital skin lesions or rashes; genitourinary symptoms; enteric conditions; other sexually transmitted infections; normal genital architecture, congenital conditions, or unconfirmed genital discharges; asymptomatic patients attending for routine examination; uninfected contacts of patients with sexually transmitted diseases; psychosexual problems; and others.
PMCID: PMC1046134  PMID: 6600641
3.  Minocycline hydrochloride (Minocin) as a single-dose oral treatment of uncomplicated gonorrhoea in men. 
349 male patients with uncomplicated gonococcal urethritis were treated with a single dose of 300 mg. or 400 mg. minocycline hydrochloride. The lower dose gave a lower failure rate, 3-2 compared with 5-1 per cent., but this difference was not statistically significant. The overall known failure rate of 4-2 per cent. compares most favourably with our previous findings in this area using other drugs of the tetracycline group. The incidence of post-gonococcal urethritis (5-1 per cent.) was also the lowest we have found. The few side-effects reported were comparatively trivial. Because of its high degree of therapeutic efficacy, the relatively lack of side-effects, and the reduced incidence of post-gonococcal urethritis, minocycline hydrochloride should be considered the drug of choice whenever single-dose oral treatment is given in uncomplicated gonorrhoea in men.
PMCID: PMC1045210  PMID: 1260407
4.  Drug misuse in a special clinic patient population in Glasgow. 
During the period October, 1970, to October, 1972, a sample of 295 patients attending Special Clinics in the City of Glasgow participated in an investigation into drug misuse. Results show that, of the 136 males and 159 females who took part--all within an age range of 16 to 24 years, 43 per cent. of the males and 36 per cent. of the females admitted to having experimented with drugs. These percentage figures on the prevalence of drug misuse compare with 36 per cent. of males and 24 per cent. of females obtained from other Glasgow-domiciled target groups, comprising a sample of 2,514 individuals. The principal drug of misuse is shown to be cannabis, followed by LSD and sleeping pills. Data on drug availability suggest that little difficulty is experienced in obtaining drugs illicitly from a variety of sources. Comparison between drug misusers and non-misusers on domestic, educational, and social variables revealed no very distinctive patterns. Results of screening for personality characteristics, using Eysenck's Psychoticism, Extraversion and Neuroticism Inventory generally confirmed previous findings related to atypical scores on the P, E, and N parameters. Even so, results obtained by means of the PEN Inventory and IPAT Anxiety Scale revealed a pattern in which drug misuse is shown to be related to even higher scores of psychoticism, neuroticism, and anxiety. The results of the investigation are discussed with particular reference to the nature of the appeal of drugs to the sexually permissive and promiscuous.
PMCID: PMC1045298  PMID: 990885
5.  Blood ethanol concentrations in patients attending special clinics in Glasgow. 
Blood samples for measurement of ethanol concentration were taken on a routine basis from 543 male and 158 female patients attending Special Clinics in Glasgow. Ethanol was detected in 56 (10-3 per cent.) of the men and eight (5-1 per cent.) of the women, and at concentrations in excess of 0-1 g./l. in 37 (6-8 per cent.) and three (1-9 per cent.) respectively. In nine men and one woman, the blood ethanol concentration was over 0-8 g./l. when they attended the clinic. The majority (84 per cent.) of positive findings were obtained in specimens collected after 2 p.m. and one-quarter on Tuesday afternoons, the local half-day. The other peak periods related to attendance at football matches on Wednesday evenings, and to receiving wages on Friday mornings. Male new patients attending a clinic for the first time had the highest incidence, 32 (11-6 per cent.) having detectable amounts of ethanol among whom 26 (9-4 per cent.) had levels in excess of 0-1 g./l., compared with only 4-1 per cent. among those either returning to the clinics with a fresh infection or on surveillance. Only 5 per cent. of female patients attending for the first time and 3 per cent. of those on surveillance had detectable amounts of ethanol in the blood, compared with 9 per cent. of those few returning with fresh infections. Levels in excess of 0-1 g./1. were only found in promiscuous women. Those with concentrations in excess of 0-8 g./1. were unreliable attenders. Only one, a known alcoholic, completed surveillance; one defaulted after his fourth visit, four after the second, and four after the first visit.
PMCID: PMC1045176  PMID: 1242684
7.  Higher medical training in venereology. 
In a review of the organisation of higher medical training in Britain leading to accreditation for those intending to specialize in venereology within the National Health Service suggestions are made for improving the present system. These include the enrollment of trainees in general medicine as well as in venereology to ensure a broad general experience of medicine. The establishment of an agreed curriculum in venereology for trainees is thought desirable. Improvement in undergraduate education in venereology is necessary if recruitment of trainees to the specialty is to be increased. The diploma courses in venereology are mainly attended by foreign graduates; the numbers are likely to be reduced by the recent heavy increases in fees. Although adequate practical experience of the tropical venereal diseases cannot be provided, these courses give a good general experience of venereology as ideally practised, much of which is relevant to the conditions under which the overseas trainees will have to work on return to their own countries. Secondment of our own trainees work in centres in developing countries as an approved part of their training would benefit both them and their hosts.
PMCID: PMC1046013  PMID: 6896008
8.  Natamycin in genital candidosis in men. 
In a trial of natamycin, an antifungal antibiotic in a vanishing cream base, assessment was possible in 66 men with genital or anal candidosis. The overall cure rate was 82 percent, In 43 patients with culturally proven candidosis it was 98 percent. but in 23 patients treated solely on clinical impression it was only 52 percent. Symptoms were rapidly relieved in those who responded and there were no side-effects. In our hands, natamycin 2 per cent cream has proved to be a valuable preparation in the treatment of candidal balanitis.
PMCID: PMC1045154  PMID: 1079741
16.  Gonorrhoea in women in Scotland. Evidence of cohorts having a higher or lower incidence than expected. 
Incidences of genital gonorrhoea in women higher or lower than expected occurred in patients aged 15--19 years four years after similar findings in those aged 10--14 years. This pattern was followed five years later in those aged 20--24, 11 years later in those aged 25--34, and 20 years later in those aged 35--44 years. Thus, cohorts of women at greater or lesser risk of acquiring gonorrhoea appear to exist. Most cohorts with a high incidence could be identified when in the 10--14 age group. Especially high rates of infection are predicted in the 25--34 age group in the mid-1980s and in the 35--44 age group in the late 1980s. These findings will affect the timing of health education on sexually transmitted diseases in schools and will demand a high degree of awareness among general practitioners, gynaecologists, and those working in family planning and well-women clinics of the possibility of gonorrhoea occurring in women in these age groups.
PMCID: PMC1045652  PMID: 486246
17.  Seasonsal variations in the reported incidence of sexually transmitted diseases in Scotland (1972-76). 
The seasonal variation in the quarterly incidence of some sexually transmitted diseases and other conditions in Scotland is compared with that of gonorrhoea and of conceptions leading to live births or abortions. The seasonal incidence for non-specific genital infections and for other conditions not requiring treatment in both men and women was similar to that of gonorrhoea, thus indicating an association with promiscuity, whereas the seasonal variation for candidosis in men and women-an infection not usually associated with promiscuity-was similar to that of conceptions. Differences between the sexes occurred, however, in the seasonal incidences of scabies, pubic lice, genital herpes, trichomoniasis, and other conditions requiring treatment; thus men with these conditions appeared to be more promiscuous than women. The seasonal variations in incidence of genital scabies and pubic lice indicate that these infestations are more easily transmitted by close bodily contact indoors during cold weather than in the open air.
PMCID: PMC1045634  PMID: 582427

Results 1-17 (17)