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1.  Oropharyngeal flora and individual susceptibility to neisserial infection. 
Beta-haemolytic streptococci were isolated from throat swabs from 49 (10.5%) of 466 patients undergoing cultural examination for gonorrhoea. Although beta-haemolytic streptococci were isolated more frequently from patients with genital or anorectal gonorrhoea (15.9%) than from those without (9.2%), the difference was not statistically significant. When groupable (A, B, C, or G) and other (non-A, -B, -C, or -G) beta-haemolytic streptococci were analysed separately, as statistically significant association between non-A, -B, -C, or -G streptococci and gonococci was observed but not between groupable beta-haemolytic streptococci and gonococci.
PMCID: PMC1045816  PMID: 6775772
2.  Clinical value of the Treponema pallidum haemagglutination test. 
In 1,129 patients attending the Department for Sexually Transmitted Diseases, the serum was examined by three screening tests (VDRL slide, RPCF, and TPHA) and twelve cases of syphilis (1 per cent. of patients attenting the clinic) were discovered. Six of these patients were considered to have latent syphilis (5 acquired, 1 congenital) and were detected only by the TPHA; all six cases were confirmed by the FTA-ABS, The TPHA failed to detect three of the remaining six cases (2 primary and 1 very early, the latter in a contact of a patient with primary syphilis). All six cases were, however, detected by the VDRL. In seven cases, the TPHA was positive in the absence of other evidence of present or previous syphilis. In these cases the FTA-ABS was also negative. The clinical application of the TPHA test in the detection of syphilis is discussed.
PMCID: PMC1045118  PMID: 1093636
5.  Gonorrhoea in Edinburgh. 
PMCID: PMC1048128  PMID: 5493151
10.  Individual susceptibility to neisserial infection? 
Specimens from genital, anorectal, and pharyngeal sites from 1671 men and 1419 women were cultured for Neisseria gonorrhoeae. Pharyngeal specimens were also cultured for Neisseria meningitidis, N. gonnorrhoeae was isolated from a genital site 2.7 times more often in men and 1.8 times more in women who also carried meningococci in their pharynx than from those who did not; the meningococcus was isolated 3.4 times more often from men and 2.0 times more often from women with genital gonorrhoea than from those without. In both men and women the association of each organism with the other was statistically significant (p less than 0.001) and may be related to sexual behaviour rather than to individual susceptibility to neisserial infection.
PMCID: PMC1045627  PMID: 111765
11.  Necrotising balanitis due to a generalised primary infection with herpes simplex virus type 2. 
Virological studies have proved herpes simplex virus type 2 to be the cause of the severe primary infection in a 37-year-old man with necrotising balanitis. Symptoms of urethritis preceded the appearance of a severe local lesion; dissemination of infection occurred and lesions developed on the skin of the scalp, neck, trunk, buttocks, arms, legs, and feet. No evidence of involvement of the central nervous system was found, and the penile and skin lesions improved rapidly after the application of 5% idoxuridine in dimethylsulphoxide. Recurrences occurred at various skin sites at six to seven months after the primary infection.
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PMCID: PMC1045581  PMID: 427514
12.  Hepatitis in early syphilis. Report of three cases. 
Fifteen patients with early syphilis were seen between May 1974 and March 1975. These 15 patients comprised all the cases of early syphilis that were seen in Edinburgh during this period. Three of them were men of whom two were homosexual. Liver function tests in these three gave abnormal results.
PMCID: PMC1045425  PMID: 589424

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