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4.  Mesothelioma Register 1967-68 
Greenberg, M., and Lloyd Davies, T. A. (1974).British Journal of Industrial Medicine,31, 91-104. Mesothelioma Register 1967-68. A register of mesothelioma cases is maintained by the Department of Employment, Medical Services Division (now Employment Medical Advisory Service). This paper describes an investigation of 413 notifications to the Register in 1967-68 from England and Wales and Scotland.
Cases were regarded as `definite' when histological confirmation of diagnosis had been obtained, either by hospital pathologists, or by the UICC Panel of Pathologists, to whom pathological material was submitted whenever possible. Two hundred and forty-six cases were accepted as `definite' and 76 cases were regarded as `definitely not' mesothelioma. The remainder were classified as `undecided' or `insufficient pathological material'. Thirty-five of the 76 cases definitely not mesothelioma had nevertheless been so described on death certificates.
The investigation carried out covers clinical aspects, survival, and evidence of exposure to asbestos. Twelve per cent of definite mesotheliomata were of peritoneal origin. The age range was 21 to 87 years, but, in general, mesothelioma occured at an earlier age than `carcinoma of bronchus and lung' or `all malignant tumours' in the Registrar General's statistical mortality tables.
Concomitant asbestosis and the finding of asbestos bodies or pleural plaques occured as frequently in those cases classified as definitely not mesothelioma as in confirmed cases.
Occupational exposure to asbestos was found in 68% of definite cases, apparently significantly more frequently than in those definitely not mesothelioma, but there was observer bias. The interval between the first exposure and death from mesothelioma exceeded 25 years in 85% of cases but was only three and a half years in one case. The duration of exposure varied widely: in 12% of cases it was under five years. The type of asbestos could be ascertained in so few cases that it was impossible to asses the rôle of crocidolite in aetiology. There were 38 definite cases in which no history of any exposure to asbestos could be obtained.
Definite mesotheliomata showed marked clustering in areas where there is substantial industrial use of asbestos. Whether this should be interpreted as evidence of causation or an effect of heightened awareness in these areas cannot be deduced from this study. Evidence is quoted suggesting that the observed annual incidence of approximately 120 definite mesotheliomata in England, Scotland, and Wales may considerably understate the true prevalence.
PMCID: PMC1009563  PMID: 4830768
5.  A radiographic survey of monumental masonry workers in Aberdeen 
Lloyd Davies, T. A., Doig, A. T., Fox, A. J., and Greenberg, M. (1973).British Journal of Industrial Medicine,30, 227-231. A radiographic survey of monumental masonry workers in Aberdeen. A survey of radiographic appearances of the lungs of monumental masonry workers in Aberdeen was carried out to determine the present prevalence of abnormalities and to serve as a standard for future comparisons in view of changes in methods of working. No major change could be detected in the status of these granite workers in Aberdeen over the past 20 years but the different methods of survey used by Mair in 1951 and by the present study did not allow of strict comparison. Chest radiographs were reported on by three readers independently using the National Coal Board elaboration of the ILO classification and a score was given to each film using Oldham's method. Multiple regression analysis showed that ϰ-ray changes were related to years in granite but progression was slow in comparison with foundry workers. The prevalence of radiographic appearances of category 1 or greater was 3·0% overall and 4·6% for workers in dusty jobs. Evidence of pneumoconiosis was not observed in workers exposed for less than 20 years.
With the environmental control attained the threshold limit values for respirable dust were not often much exceeded.
PMCID: PMC1009516  PMID: 4353240
6.  URINARY EXCRETION OF PHENOL BY MEN EXPOSED TO VAPOUR OF BENZENE: A SCREENING TEST 
The metabolism of benzene differs from that of other aromatic hydrocarbons; the excretion of phenol in the urine of workers exposed to ambient benzene bears a linear relationship to the degree of exposure. A semi-quantitative screening test using stable reagents not requiring special apparatus or laboratory facilities permits an estimation of urinary phenolic bodies, and hence the exposure to benzene. The test may be used (a) to determine whether individual workers need further investigation because of exposure to benzene, (b) as a group test to determine whether the environment is acceptable, and (c) to determine whether solvents often regarded as safe contain benzene.
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PMCID: PMC1008211  PMID: 14261703
8.  Manganese Pneumonitis 
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PMCID: PMC1036177  PMID: 18119365
10.  Manganese Pneumonitis 
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PMCID: PMC1035745  PMID: 20991170

Results 1-10 (10)