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2.  Observations on the effects on rats of compounds related to acrylamide 
Barnes, J. M. (1970).Brit. J. industr. Med.,27, 147-149. Observations on the effects on rats of compounds related to acrylamide. Nine compounds (Table), close chemical relations of acrylamide, were given to adult rats both in their diet and as repeated daily doses by mouth. Dose rates were such that with acrylamide acute poisoning and neuropathy would have resulted. Seven of the compounds were without effect. N-methylacrylamide and N-hydroxymethylacrylamide produced some neurotoxic effects in large doses. The presence of acrylamide as an impurity in the compound tested was not excluded.
PMCID: PMC1009088  PMID: 5428633
3.  Effects of carbon disulphide on the liver of rats 
Bond, E. J., Butler, W. H., de Matteis, F., and Barnes, J. M. (1968).Brit. J. industr. Med.,26, 335-337. Effects of carbon disulphide on the liver of rats. Normal rats surviving a single oral dose of carbon disulphide (CS2) show liver enlargement and depression of drug-metabolizing enzymes but no liver necrosis. If the drug-metabolizing enzymes are stimulated by phenobarbitone before exposure to CS2, the LD50 does not change but liver necrosis is produced.
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PMCID: PMC1008993  PMID: 5346831
4.  Peripheral Neuropathy in Rats Produced by Acrylamide 
Acrylamide produces ataxia and limb weakness in rats when given in repeated oral doses of 25 100 mg./kg. at various intervals or mixed with the diet in concentrations of 100 to 400 p.p.m.
An electrophysiological and histological study of peripheral nerves has been carried out in chronical poisoned rats. In animals with severe clinical abnormalities, motor nerve conduction velocity in the fibr supplying the small muscles of the hind paw was reduced to approximately 80% of the control value.
Histologically, degeneration of axis cylinders and myelin sheaths was found in peripheral nerve affecting predominantly the distal parts of the longest fibres.
When paralysed animals were no longer given acrylamide, they recovered clinically, conduction velocity returned to the normal range, and there was histological evidence of regeneration of nerve fibres.
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PMCID: PMC1008431  PMID: 4287726
5.  Some Toxic Effects of Dieldrin in Rats 
The oral toxicity of dieldrin in rats depends upon its concentration in the vehicle (arachis oil). It is increased by a previous restriction of diet, leading to a loss of weight. Two equal doses given within three weeks of each other are more toxic than the sum of the two given as a single dose.
PMCID: PMC1038402  PMID: 14249896
15.  Some Toxic Properties of Dimethylnitrosamine 
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PMCID: PMC1037552  PMID: 13182155

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