PMCC PMCC

Search tips
Search criteria

Advanced
Results 1-2 (2)
 

Clipboard (0)
None
Journals
Authors
Year of Publication
Document Types
1.  Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] 
New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR (1H, 13C, and 31P), and electronic spectral data. The X-ray crystal structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl2] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).
doi:10.1155/2010/149149
PMCID: PMC2909729  PMID: 20671978
2.  The First Metal Complexes of 4,6-diamino-1-hydro-5-hydroxy-pyrimidine-2-thione: Preparation, Physical and Spectroscopic Studies, and Preliminary Antimicrobial Properties 
The new complexes [M2O5L2(H2O)2] · H2O (M = Mo, 1; M = W, 2), [RuL2(H2O)2] · H2O (3), [ML3] · xH2O (M = Rh, x = 2, 4; M = Ir, x = 1, 5), [RhL2(PPh3)2](ClO4) · 2H2O (6), [PdL2] · 2H2O (7), [PdL(phen)]Cl · H2O (8), [Re OL2(PPh3)]Cl (9) and [UO2L2] (10) are reported, where LH is 4,6-diamino-1-hydro-5-hydroxy-pyrimidine-2-thione. The complexes were characterized by elemental analyses, physical techniques (molar conductivity, room-temperature magnetic susceptibility), and spectroscopic (IR, Raman, UV/VIS/ligand field, NMR, mass) methods. The ligand L− is in its thione form and behaves as a bidentate chelate with the deprotonated (hydroxyl) oxygen and the nitrogen of one amino group as donor atoms. Oxobridged dinuclear (1, 2) and various mononuclear (3–10) structures are assigned for the complexes in the solid state. The metal ion coordination geometries are octahedral (1–6, 9, 10) or square planar (7, 8). The free ligand LH and complexes 1, 4, 7, and 8 were assayed in vitro for antimicrobial activity against two bacterial and two fungal cultures.
doi:10.1155/2008/647873
PMCID: PMC2659754  PMID: 19325921

Results 1-2 (2)