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1.  Fertility Regulation in Male Rats by Implemented Tetraazamacrocyclic Compounds of Iron(II): Synthetic, Spectroscopic, and Applied Aspects With Toxicological Screening 
Antifertility and histopathological investigations were carried out on reproductive organs of male albino rats induced by tetraazamacrocyclic complexes of iron(II). The complexes were synthesized by the template condensation of 1,2-diaminoethane, 1,3-diaminopropane with succinic acid and phthalic acid in 2 : 2 molar ratios which are abbreviated as [Fe(TAMLn)OAc] (n = 1 or 2 and TAMLn represents tetraazamacrocyclic ligand). The complexes have been characterized by elemental analysis, conductivity measurements, IR, and electronic spectra.
doi:10.1155/BCA/2006/17316
PMCID: PMC1686297  PMID: 17497000
2.  Potentially Biodynamic Tetraaza Macrocycles and their Manganese Complexes: Antiandrogen, Antimicrobial and PDI Studies 
Fourteen to eighteen membered tetraazamacrocyclic ligands N4TTD1–N4TTD4 have been synthesized by the condensation of aliphatic diamines. H2N–(CH2)y–NH2 (y = 2 or 3) and dicarboxylic acids, HOOC-(CH2)x–COOH (x = 1 or 2) in the presence of condensing reagents dicyclohexylcarbodiimide (DCHC) and 4-dimethylaminopyridine (DMAP). On reduction these macrocyclic ligands give N4TTD5-N4TTD8, which form complexes with manganese(II) acetate. The new products with octahedral geometry have been characterized by elemental analyses, molecular weight determinations, magnetic moment and spectral studies viz., infrared, electronic, mass and X-ray. On the basis of the spectral studies the binding sites are proposed as the nitrogen atom of the macrocycles. The formulation of the complexes as [Mn(CH3COO)2(N4TTDn)] (where n = 1 - 8) has been established on the basis of chemical composition. To assess the growth inhibiting potential of the ligands and their manganese (II) complexes biological screening have been undertaken. The testicular morphology, testicular sperm density, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs with ligands and their corresponding complexes, in vivo have also been described in the this communication.
doi:10.1155/BCA.2005.161
PMCID: PMC2267104  PMID: 18365097
3.  Fertility Inhibitors Macrocyclic Complexes of Bivalent Manganese: Synthetic, Spectroscopic and Medicinal Approach 
The modern physico-chemical, spectroscopic and biochemical methods have proved an important tool to elucidate the constitution of transition metal complexes. This paper presents a brief account of the synthesis, spectroscopic and medicinal aspects of tetraazamacrocyclic compounds of manganese(II). Sixteen to eighteen membered tetraamide macrocyclic ligands DTTD1 and DTTD2 have been synthesized by the condensation of 1,2-diaminoethane and 1,3-diaminopropane with phthalic acid in the presence of condensing reagents dicyclohexylcarbodiimide and 4-dimethylaminopyridine. On reduction these macrocyclic ligands give new tetraazamacrocycles TTD1 and TTD2 which form complexes with manganese (II) nitrate and manganese (II) acetate. Based on chemical analyses, molecular weight determinations, conductance measurements, magnetic moment, IR spectra, 1H NMR, 13C NMR spectra, electronic spectra, mass spectra and X-ray spectral analysis, an octahedral geometry has been assigned to the newly synthesized products. The formulation of the complexes of the type [Mn(TTDn)X2] [where, n or 2, X (NO3) or (CH3COO)] has been established on the basis of chemical composition. The possibilities of potential uses of these complexes as fungicides and bactericides, studied in vitro, are also discussed. The testicular sperm density, sperm morphology, sperm mortality, density of cauda epididymis, spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs of rat have been examined and discussed.
doi:10.1155/S1565363303000190
PMCID: PMC2267058  PMID: 18365057

Results 1-3 (3)