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1.  Welcome to BioArchitecture 2013 
Bioarchitecture  2013;3(1):1.
The first major hurdle for any new journal is to achieve acceptance into Medline/PubMed. I am pleased to report that BioArchitecture was accepted into Medline/PubMed in August 2012. This means that accepted manuscripts are immediately visible through their listing on PubMed. This is very welcome news to contributors to the journal and makes the journal a more attractive destination for publication of new research findings.
doi:10.4161/bioa.24027
PMCID: PMC3639238
2.  BioArchitecture 
Bioarchitecture  2012;2(6):200-203.
BioArchitecture is a term used to describe the organization and regulation of biological space. It applies to the principles which govern the structure of molecules, polymers and mutiprotein complexes, organelles, membranes and their organization in the cytoplasm and the nucleus. It also covers the integration of cells into their three dimensional environment at the level of cell-matrix, cell-cell interactions, integration into tissue/organ structure and function and finally into the structure of the organism. This review will highlight studies at all these levels which are providing a new way to think about the relationship between the organization of biological space and the function of biological systems.
doi:10.4161/bioa.22726
PMCID: PMC3527313  PMID: 23267413
actin; cytoskeleton; microtubules; intermediate filaments; nuclear structure; protein folding; isoform sorting
3.  BioArchitecture  
Bioarchitecture  2012;2(1):1.
Volume 1 has defined the scope of BioArchitecture. From the outset we have strived to ensure that BioArchitecture is not limited to the three major polymer systems of the cytoplasm. I am happy to say that a cursory glance at the contents of volume 1 makes it clear that we are interested in all aspects of bioarchitecture from molecules to polymers to cells to tissue to the organism.
PMCID: PMC3383710  PMID: 22754619
4.  TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses 
Bioarchitecture  2011;1(6):284-289.
Synaptic function in the central nervous system (CNS) is highly dependent on a dynamic actin cytoskeleton in both the pre- and the postsynaptic compartment. Remodelling of the actin cytoskeleton is controlled by tropomyosins, a family of actin-associated proteins which define distinct actin filament populations. Here we show that TPM3 and TPM4 gene products localize to the postsynaptic region in mouse hippocampal neurons. Furthermore our data confirm previous findings of isoform segregation to the pre- and postsynaptic compartments at CNS synapses. These data provide fundamental insights in the formation of functionally distinct actin filament populations at the pre- and post-synapse.
doi:10.4161/bioa.1.6.19336
PMCID: PMC3337131  PMID: 22545181
actin cytoskeleton; central nervous system; postsynapse; tropomyosin
5.  Functional identity of the gamma tropomyosin gene 
Bioarchitecture  2011;1(1):49-59.
The actin filament system is fundamental to cellular functions including regulation of shape, motility, cytokinesis, intracellular trafficking and tissue organization. Tropomyosins (Tm) are highly conserved components of actin filaments which differentially regulate filament stability and function. The mammalian Tm family consists of four genes; αTm, βTm, γTm and δTm. Multiple Tm isoforms (>40) are generated by alternative splicing and expression of these isoforms is highly regulated during development. In order to further identify the role of Tm isoforms during development, we tested the specificity of function of products from the γTm gene family in mice using a series of gene knockouts. Ablation of all γTm gene cytoskeletal products results in embryonic lethality. Elimination of just two cytoskeletal products from the γTm gene (NM1,2) resulted in a 50% reduction in embryo viability. It was also not possible to generate homozygous knockout ES cells for the targets which eliminated or reduced embryo viability in mice. In contrast, homozygous knockout ES cells were generated for a different set of isoforms (NM3,5,6,8,9,11) which were not required for embryogenesis. We also observed that males hemizygous for the knockout of all cytoskeletal products from the γTm gene preferentially transmitted the minus allele with 80–100% transmission. Since all four Tm genes are expressed in early embryos, ES cells and sperm, we conclude that isoforms of the γTm gene are functionally unique in their role in embryogenesis, ES cell viability and sperm function.
doi:10.4161/bioa.1.1.15172
PMCID: PMC3158640  PMID: 21866263
cytoskeleton; actin; tropomyosin; redundancy; isoforms

Results 1-5 (5)