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1.  Phage as a source of antibacterial genes 
Bacteriophage  2011;1(4):195-197.
Bacteriophage-encoded proteins which inhibit or modify cellular components may contribute to antibacterial drug discovery by allowing the identification of novel targets. Given their abundance and diversity, phages may have various strategies in host inhibition and therefore may possess a variety of such proteins. Using Rhodococcus equi and phage YF1, we show that a single phage possesses numerous genes that inhibit the host when introduced into the host on a plasmid. These genes mostly encode proteins of unknown function, confirming the potential that this approach may have in providing new antibacterial targets.
doi:10.4161/bact.1.4.17746
PMCID: PMC3448104  PMID: 23050212
antibacterial drug discovery; bactericidal proteins; multidrug resistance; phage YF1; target identification

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