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1.  Gated Diffusion-controlled Reactions 
BMC Biophysics  2011;4:4.
The binding and active sites of proteins are often dynamically occluded by motion of the nearby polypeptide. A variety of theoretical and computational methods have been developed to predict rates of ligand binding and reactivity in such cases. Two general approaches exist, "protein centric" approaches that explicitly treat only the protein target, and more detailed dynamical simulation approaches in which target and ligand are both treated explicitly. This mini-review describes recent work in this area and some of the biological implications.
PMCID: PMC3093672  PMID: 21595999
2.  Diffusion and association processes in biological systems: theory, computation and experiment 
BMC Biophysics  2011;4:2.
Macromolecular diffusion plays a fundamental role in biological processes. Here, we give an overview of recent methodological advances and some of the challenges for understanding how molecular diffusional properties influence biological function that were highlighted at a recent workshop, BDBDB2, the second Biological Diffusion and Brownian Dynamics Brainstorm.
PMCID: PMC3093674  PMID: 21595997

Results 1-2 (2)