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3.  Open questions: A rose is a rose is a rose - or not? 
BMC Biology  2014;12:2.
doi:10.1186/1741-7007-12-2
PMCID: PMC3909284  PMID: 24484903
4.  Open questions: a few that need answers in immunology 
BMC Biology  2013;11:115.
doi:10.1186/1741-7007-11-115
PMCID: PMC3842812  PMID: 24279517
6.  Low-dose radiation, scientific scrutiny, and requirements for demonstrating effects 
BMC Biology  2013;11:92.
Recent nuclear accidents have prompted renewed interest in the fitness consequences of low-dose radiation. Hiyama et al. provided information on such effects in the Japanese pale grass blue butterfly in a paper that has been viewed more than 300,000 times, prompting a barrage of criticism. These exchanges highlight the role of scrutiny in studies with potential effects on humans, but also raise questions about minimum requirements for demonstrating biological effects.
doi:10.1186/1741-7007-11-92
PMCID: PMC3765500  PMID: 23987799
7.  Tony Pawson and the germination and flowering of cell signaling: an appreciation 
BMC Biology  2013;11:95.
doi:10.1186/1741-7007-11-95
PMCID: PMC3765445  PMID: 24502764
9.  The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated? 
BMC Biology  2013;11:79.
Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial. Here, we focus on the debate surrounding the evolutionary importance of interactions between resistance loci and argue that its role in explaining overall variance in disease outcomes may have been overestimated.
doi:10.1186/1741-7007-11-79
PMCID: PMC3711976  PMID: 23855805
10.  Mitochondrial network morphology: building an integrative, geometrical view 
BMC Biology  2013;11:71.
The morphology of mitochondrial networks is complex and highly varied, yet vital to cell function. The first step toward an integrative understanding of how mitochondrial morphology is generated and regulated is to define the interdependent geometrical features and their dynamics that together generate the morphology of a mitochondrial network within a cell. Distinct aspects of the size, shape, position, and dynamics of mitochondrial networks are described and examples of how these features depend on one another discussed.
doi:10.1186/1741-7007-11-71
PMCID: PMC3691739  PMID: 23800141
11.  Open questions: A logic (or lack thereof) of genome organization 
BMC Biology  2013;11:58.
doi:10.1186/1741-7007-11-58
PMCID: PMC3665519  PMID: 23714162
12.  Thirty years on: HIV receptor gymnastics and the prevention of infection 
BMC Biology  2013;11:57.
During 30 years of research on human immunodeficiency virus (HIV), our knowledge of its cellular receptors - CD4, CCR5 and CXCR4 - has illuminated aspects of the pathogenesis of the acquired immune deficiency syndrome (AIDS). Studying how the HIV envelope glycoproteins interact with the receptors led to anti-retroviral drugs based on blocking the docking or fusion of virus to the host cell. Genetic polymorphisms of CCR5 determine resistance to HIV infection and the rate of progression to AIDS. Eliciting neutralizing antibodies to the sites of receptor interaction on HIV glycoproteins is a promising approach to HIV vaccine development.
doi:10.1186/1741-7007-11-57
PMCID: PMC3660199  PMID: 23692808
AIDS; HIV; cell receptors; CD4; CCR5; CXCR4; Therapy
13.  Of flies and men: insights on organismal metabolism from fruit flies 
BMC Biology  2013;11:38.
The fruit fly Drosophila has contributed significantly to our general understanding of the basic principles of signaling, cell and developmental biology, and neurobiology. However, answers to questions pertaining to energy metabolism have been so far mostly addressed in more complex model organisms such as mice. We review in this article recent studies that show how the genetic tractability and simplicity of Drosophila are being used to identify novel regulatory mechanisms at the organismal level, and to query the co-ordination between energy metabolism and other processes such as neurodegeneration, circadian rhythms, immunity, and tumor biology.
doi:10.1186/1741-7007-11-38
PMCID: PMC3626883  PMID: 23587196
14.  Tenth anniversary updates from our authors 
BMC Biology  2013;11:39.
doi:10.1186/1741-7007-11-39
PMCID: PMC3626886  PMID: 23587215
15.  Domesticating the beast 
BMC Biology  2013;11:35.
doi:10.1186/1741-7007-11-35
PMCID: PMC3626916  PMID: 23587154
16.  A view forward from ten years of BMC Biology 
BMC Biology  2013;11:32.
doi:10.1186/1741-7007-11-32
PMCID: PMC3626927
17.  Open questions: Reflections on plant development and genetics 
BMC Biology  2013;11:25.
doi:10.1186/1741-7007-11-25
PMCID: PMC3614448  PMID: 23537373
18.  Open questions: Epigenetics and the role of heterochromatin in development 
BMC Biology  2013;11:21.
doi:10.1186/1741-7007-11-21
PMCID: PMC3598382  PMID: 23497103
19.  Q&A: Re-review opt-out and painless publishing 
BMC Biology  2013;11:18.
doi:10.1186/1741-7007-11-18
PMCID: PMC3584977  PMID: 23445866
20.  Open questions: What is there left for cell biologists to do? 
BMC Biology  2013;11:16.
doi:10.1186/1741-7007-11-16
PMCID: PMC3583729  PMID: 23445835
21.  Open questions in biology - a tenth anniversary series 
BMC Biology  2013;11:7.
doi:10.1186/1741-7007-11-7
PMCID: PMC3561168  PMID: 23369191
23.  Open questions: Chromosome condensation - Why does a chromosome look like a chromosome? 
BMC Biology  2013;11:9.
doi:10.1186/1741-7007-11-9
PMCID: PMC3561182  PMID: 23369232
24.  Open questions: missing pieces from the immunological jigsaw puzzle 
BMC Biology  2013;11:10.
doi:10.1186/1741-7007-11-10
PMCID: PMC3561189  PMID: 23369631
25.  Cilia, calcium and the basis of left-right asymmetry 
BMC Biology  2012;10:102.
The clockwise rotation of cilia in the developing mammalian embryo drives a leftward flow of liquid; this genetically regulated biophysical force specifies left-right asymmetry of the mammalian body. How leftward flow is interpreted and information propagated to other tissues is the subject of debate. Four recent papers have shed fresh light on the possible mechanisms.
doi:10.1186/1741-7007-10-102
PMCID: PMC3527145  PMID: 23256866

Results 1-25 (54)