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1.  Anticonvulsant activity of raw and classically processed Vacha (Acorus calamus Linn.) rhizomes 
Ayu  2012;33(1):119-122.
The rhizome of Vacha (Acorus calamus) has been used in Ayurvedic medicine for the treatment of various ailments, such as epilepsy, headache, eye disorders, insomnia, loss of memory, etc. Previous studies demonstrated that Vacha rhizome is having significant anticonvulsant activity against various induced seizures models in experimental animals. Ayurvedic pharmacopoeia of India has advocated Shodhana (purificatory procedures) to be done prior to its use. In the present study a comparative anticonvulsant activity of raw and Shodhita (classically processed) Vacha rhizomes were screened against Maximal Electro Shock (MES) seizure model to assess the effect of classical purificatory procedure on pharmacological action of Vacha. Phenytoin was used as standard antiepileptic drug for comparison. Pretreatment with both raw and classically processed Vacha samples exhibited significant anticonvulsant activity by decreasing the duration of tonic extensor phase. Further classically processed Vacha statistically decreased the duration of convulsion and stupor phases of MES-induced seizures. The results obtained from the present study clearly confirmed the anticonvulsant activity of raw Vacha and subjecting to classical Shodhana procedure did not alter the efficacy of Vacha rhizomes instead it enhanced the activity profile of the Vacha.
doi:10.4103/0974-8520.100328
PMCID: PMC3456849  PMID: 23049196
Acorus calamus; anticonvulsant; epilepsy; phenytoin; shodhana; vacha
2.  Study on the diuretic activity of Euphorbia fusiformis Buch.-Ham. in albino rats 
Ayu  2011;32(3):385-387.
The present study was undertaken to evaluate diuretic activity of Euphorbia fusiformis root powder in Wistar strain albino rats. Randomly selected animals were divided into three groups of six animals each. The root powder was suspended in distilled water and administered orally at a dose of 90 mg/kg therapeutically equivalent dose (TED) and 180 mg/kg (TED × 02) to overnight fasted rats. The diuretic activity was evaluated by determination of urine volume and urinary electrolyte concentrations. Test drug showed significant increase in urine volume and urinary electrolyte excretion in a dose-dependant manner. Thus, from this study, it can be concluded that roots of E. fusiformis possess diuretic activity.
doi:10.4103/0974-8520.93920
PMCID: PMC3326888  PMID: 22529656
Albino rats; diuretic activity; Euphorbia fusiformis; urine volume
3.  Antipyretic activity of Guduchi Ghrita formulations in albino rats 
Ayu  2010;31(3):367-370.
The present pharmacological investigation was undertaken to study the anti-pyretic activity of Guduchi ghrita formulations in albino rats against yeast induced pyrexia. Seven groups of six animals were used for the experiment. The yeast induced pyrexia method was standardized first by injecting 12.5% yeast suspension (s.c) followed by recording the rectal temperature at regular intervals. Then the evaluation of anti-pyretic activity of Guduchi ghrita formulations was carried out by using this standard procedure. Both the Guduchi ghrita samples including vehicle significantly attenuated the raise in temperature after three hours of yeast injection. After 6 and 9 hours of yeast injection also both the Guduchi ghrita samples attenuated the raise in temperature in a highly significant manner in comparison to both yeast control and vehicle control groups. The data generated during study shows that both the Guduchi ghrita formulations having significant anti-pyretic activity.
doi:10.4103/0974-8520.77162
PMCID: PMC3221073  PMID: 22131741
Guduchi Ghrita; pyrexia; Brewer's yeast; paracetamol; Tinospora cordifolia (Willd.) Miers. medicated ghee
4.  Critical analysis of herbs acting on Mutravaha srotas 
Ayu  2010;31(2):167-169.
Ayurveda has given prime importance to Mutravaha srotas (urinary system) and Srotogata Vikaras (urinary disorders). Being a system responsible for homeostasis of fluids in the body it also detoxifies the body by eliminating certain waste products through urine. When diseased, people produce symptoms such as, increased or decreased urine production, painful maturition, formation of stones, and thereby obstructed micturition, increased frequency of micturition, and so on. There are many herbs with varied actions specifically aimed at mitigating urinary system disorders. Drugs such as Jambu, Amrasthi, and the like, reduce the increased flow of urine, and hence, are considered as Mutrasangrahaneeya, whereas, drugs like Ikshu, Kustha, and so on, increase the flow of urine, and hence, are considered as Mutravirechaneeya. There are drugs like Padma, Utpala, and so on, which impart normal color to the urine and are known as Mutravirajaneeya dravyas. Asmarighna dravyas break down the calculi and remove them through the urine. These dravyas, when used under proper direction, help in relieving the pain and apathy caused by the disease.
doi:10.4103/0974-8520.72379
PMCID: PMC3215359  PMID: 22131705
Ashmarighna dravya; Mutrasangrahaneeya dravya; Mutravirajaneeya dravya; Mutravirechaneeya dravya; urinary system; herbs

Results 1-4 (4)