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1.  Efficacy of Triphaladi Avaleha on Beejadushtijanya Pandu (Thalassemia) 
Ayu  2014;35(1):15-21.
Background:
Hemoglobinopathies constitute a major public health problem internationally, particularly in the developing world as it has the least resources for coping with the problem. Thalassemia is an inherited single-gene autosomal recessive disorder of the Red Blood Corpuscles (RBCs). Life becomes miserable due to blood transfusion every fortnight, recurrent infections, stunted growth, problems of iron overload, splenectomy, and decreased school performance. Nearly Rs. 1000 Crore is being spent in the treatment of thalassemia per annum.
Aim:
To evaluate the efficacy of Triphaladi Avaleha in Beejadushtijanya Pandu (thalassemia).
Materials and Methods:
Total 32 patients of age group 1-15 years were registered and randomly divided into two groups. Group A (test drug treated group) and Group B (control group). In Group A, Triphaladi Avaleha was given with Godugdha, and in Group B, Deferiprone was administered. Assessment was done based on the subjective and objective parameters after 12 weeks of treatment, with a follow-up of 8 weeks.
Results:
The trial drug proved better than the standard control in Paandutaa and Sandhishoola at a highly significant level and in Jwara, Akshikootashotha and Pindikodweshtana at a significant level. In Group A, five patients (38.46%) showed maximum improvement, five patients (38.46%) showed moderate improvement, two patients (15.38%) had mild improvement.
Conclusion:
Triphaladi Avaleha has various properties which help to relieve the signs and symptoms of the disease, as well as decrease the iron overload.
doi:10.4103/0974-8520.141898
PMCID: PMC4213961  PMID: 25364194
Beejadushtijanya Pandu; thalassemia; Triphaladi Avaleha
2.  Comparative study on the effect of Saptamrita Lauha and Yoga therapy in myopia 
Ayu  2014;35(1):22-27.
Background:
Myopia is very common ophthalmic disease especially in children and adolescence. In Ayurvedic texts, only by the main feature impairment of distant vision myopia can be correlated with Drishtigata Rogas (2nd Patalgata Timira).
Aim:
To compare the effect of Saptamruta Lauha and Yoga therapy in myopia.
Materials and Methods:
In present study, a total 60 patients with age group between 8 to 30 years were selected randomly from the out-patient Department of Swasthavritta and Shalakyatantra Department of Government Ayurveda College, Trivandrum, and were divided in two groups. In Group A, Saptamrita Lauha 250 mg twice daily with unequal quantity of honey and Ghrita was administered while in Group B, patients subjected to Yoga therapy (Jala Neti, Nadi Shodhana, Shitali Pranayama and point Tratak) for 3 months duration with 1 month follow-up.
Results and Conclusion:
The result obtained from the study reveals that there is no significant reduction in the visual acuity and clinical refraction, but associated changes were observed as reduced in group B when compared to group A. However, relief from headache was found to be equally effective in both the groups.
doi:10.4103/0974-8520.141904
PMCID: PMC4213962  PMID: 25364195
Jala Neti; Nadi Shodhana; point Tratak; Sapthamrita Lauha; Shitali Pranayama
3.  Clinical evaluation of Lekhaniya Kashaya Vasti in the management of Sthaulya (obesity) 
Ayu  2014;35(1):28-34.
Background:
Obesity is considered the world's oldest metabolic disorder. It is not a single disease entity, but a syndrome with many causes including combination of genetic, nutritional and sociological factors. The World Health Organization (WHO) considers obesity as “Insidious, creeping pandemic which is now engulfing the entire world”. Diet and life-style play a significant role both in the development and control of obesity Sthaulya (obesity). In Ayurveda, Acharyas have mentioned about the use of Lekhaniya Vasti to manage the Sthaulya.
Aim:
To evaluate the efficacy of Lekhaniya Kashaya Vasti in patients of Sthaulya.
Materials and Methods:
A total of 70 patients of Sthaulya were registered. Further they were divided into 2 groups each having 35 patients. In Group I (Lekhaniya Kashaya Vasti) group out of 35 patients 32 and in Group II (Pathya) group out of 35 patients 33 completed the follow-up.
Results:
In Group I, mean change was observed in body mass index (P < 0.001), waist hip ratio (P < 0.001). Overweight (P < 0.001), Kshudraswas (breathlessness) (P < 0.001) and Nidraadhikyata (excessive sleep) (P < 0.001) which is statistically significant in comparison with Group II.
Conclusion:
Trial drug is very good combination for Medoghna activity.
doi:10.4103/0974-8520.141907
PMCID: PMC4213963  PMID: 25364196
Lekhaniya Vasti; metabolic disorder; obesity; Pathya; Sthaulya
4.  Effect of Pippalimula on Ama w.s.r. to Samavaya 
Ayu  2014;35(1):35-41.
Background:
Shad Karanas mentioned in Ayurveda are the means for attaining the state of Dhatusamyata. Samavaya is the sixth Karana among these and it provides the knowledge of relation between Dravya, Guna and Karma. This kind of knowledge becomes the basic tool in the field of diagnosis as well as in the selection of proper drug.
Aim:
To assess the Samavaya relation between Ama and its Hetu and Lakshanas along with Practical evaluation of Samavaya by using Pippalimula on Ama.
Materials and Methods:
The study comprising of total 23 patients of Ama and divided into two groups. Pippalimula tablet (each of 500 mg, 2 tablets four times daily) was administered in Group A (n = 13) while Group B (n = 10) was treated with placebo tablet (each of 500 mg, 2 tablets four times daily) for the duration of 10 days.
Results:
After the completion of treatment, all the parameters of Group A showed statistically highly significant results, whereas in Group B some parameters showed significant results and others were insignificant.
Conclusion:
The study specified the Karanatva of Samavaya as the Laghu, Ruksha and Ushna Gunas which were present Samavayatvena in Pippalimula, and were absent in placebo.
doi:10.4103/0974-8520.141911
PMCID: PMC4213965  PMID: 25364197
Ama; Pippalimula; Samavaya; Shadkarana
5.  Clinical evaluation of Krimidanta Pratishedha (anti-caries) activity of Triphaladi Gandusha in high risk dental caries patients 
Ayu  2014;35(1):42-45.
Background:
Dental caries is the most common complaint encountered in clinical practice. Virtually every adult in the world has experience of dental caries. It affects almost 80% of the population. It is now being viewed in dual perspective- “caries as a disease” and “caries as a lesion”.
Aims:
To evaluate the efficacy of Triphaladi Gandusha for its anti-caries activity and improvement in Oral Hygiene Index in high risk patients of dental caries and to compare the efficacy of prevalent method of mouth rinsing and classical method of Gandusha.
Materials and Methods:
The study was conducted in 40 patients, 20 in each Group-1 and 2. Group -1 was given prepared Triphaladi mouthwash (mouth rinse) while Group-2 was given Triphaladi Kwath for Gandusha (retention).
Results:
The effect of treatment was assessed by subjective and objective parameters (like salivary pH, buffering capacity and microbial count). Triphaladi Gandusha (retention) in Group - 2 provided better results in the improvement of Ruja (toothache), Dantaharsha (tooth sensitivity), Sarambha (inflammation), pH of saliva, microbial count in salivary sample. And Triphaladi Mouthwash in Group - 1 provided better results in Srava (discharge), bad breath, pH of saliva and buffering capacity of salivary sample. There was no improvement in Chidrata (cavity formation), Krishnata (discoloration) and Chaladanta (mobility) with Triphaladi Gandusha and mouthwash.
Conclusion:
Study concluded that although both groups were effective, but Gandusha group patients’ got better relief in subjective symptoms compared to mouthwash group.
doi:10.4103/0974-8520.141916
PMCID: PMC4213966  PMID: 25364198
Dental caries; Krimidanta; Saliva; Triphaladi Gandusha
6.  Evaluation of antioxidant potential of Rasayana drugs in healthy human volunteers 
Ayu  2014;35(1):46-49.
Background:
It is increasingly being realized that many of today's diseases are due to “oxidative stress” that results from an imbalance between formation and neutralization of free radicals. Rasayana Chikitsa is a unique branch of Ayurveda. The word Rasayana means the way for attaining excellent Rasadi Dhatus. Several medicinal plants have been described as Rasayanas in Ayurveda. Ashwagandha and Guduchi are the best among the Rasayanas described by Charaka.
Aim:
To study the efficacy of Ashwagandha and Guduchi in oxidative stress in healthy volunteers.
Materials and Methods:
The study was carried out on 30 healthy volunteers after obtaining written informed consent. They were randomly distributed in three groups. Each group was treated with three different colored capsules containing Ashwagandha, Guduchi and placebo in the dose of 1 capsule (500 mg) twice a day for 6 months. The parameters such as hemoglobin%, Erythorcyte Sedimentation Rate (ESR), Malondialdehyde (MDA), Super-Oxide Dismutase (SOD) level, etc., were assessed before and after treatment. The Student's t-test was applied to assess significant variations in all of the studied parameters.
Results:
In this study, there was a significant increase in SOD level and decrease in MDA level in Ashwagandha and Guduchi groups.
Conclusion:
Ashwagandha and Guduchi may be helpful in preventing the oxidative stress and premature aging.
doi:10.4103/0974-8520.141919
PMCID: PMC4213967  PMID: 25364199
Ashwagandha; Guduchi; malondialdehyde; oxidative stress; Rasayana; super-oxide dismutase
7.  Management of Vyanga (facial melanosis) with Arjuna Twak Lepa and Panchanimba Churna 
Ayu  2014;35(1):50-53.
Background:
Vyanga is one of the Kshudraroga, characterized by the presence of Niruja (painless) and Shavavarna Mandalas (bluish-black patches) on face. It is one of the most common diseases as regards the face is concerned. On the basis of clinical features, it can be compared with facial melanosis, one of the hyper pigmented disorders. Drugs with Rakta Prasadaka, Twak Prasadaka and Varnyakara properties are helpful in the management of Vyanga, that pacifies aggregated Doshas and help in Raktashodhana (blood purification).
Aim:
To evaluate the efficacy of Arjunatwak Lepa and Panchanimba Churna in Vyanga.
Materials and Methods:
In this study, the trial drugs used were Arjunatwak Churna for Lepa (tropical application) and Panchanimba Churna for oral administration. A total 30 patients of Vyanga were selected from outpatient department and inpatient department of Shalakya Tantra Department and allotted randomly in two groups. In group-A, the patients were treated with external application of Arjunatwak Churna and Madhu for 21 days, while in group-B, patients received Panchanimba Churna orally for 21 days in addition to Arjunatwak Churna for Lepa. Effect of therapy on chief complaint i.e., bluish-black pigmentation in Group A was 60% relief, while in Group B 80% relief was found.
Conclusion:
The clinical study has shown that combined therapy gives better results than topical treatment.
doi:10.4103/0974-8520.141924
PMCID: PMC4213969  PMID: 25364200
Arjunatwak Churna; facial melanosis; Panchanimba Churna; Vyanga
8.  Assessment of Lekhana Basti in the management of hyperlipidemia 
Ayu  2013;34(4):339-345.
Hyperlipidemia is highly prevalent and is closely related to coronary heart disease which is the most common cause of death. Raised cholesterol is estimated to be responsible for 18% of cerebrovascular disease and 56% of ischemic heart disease. Overall, these diseases account for about 4.4 million deaths (7.9% of the total). Based upon the etiological factors and symptom complexes, hyperlipidemia can be considered as a part of Medoroga. Being a Tikshna formulation, the treatment modality of Lekhana Basti is aimed basically for Apatarpana (emaciation) of the body, as Basti is the fastest Apatarpana. In the present clinical trial, a total of 22 patients were registered of whom 19 patients completed the course of the therapy. Under randomization, the registered patients were divided into two groups of which group A was treated with Lekhana Basti and group B was administered standard control drug, i.e., Triphala Guggulu, for 21 days. The results of the study revealed that in patients treated with Lekhana Basti, there was a decrease of about 4.99% in S. cholesterol, 9.13% in S. low density lipoprotein (LDL), and 0.36% in S. apolipoprotein B. Lekhana Basti was found to have significant effect in reducing the symptoms of Medodushti and in reduction of objective parameters like weight, body mass index (BMI), body fat percentage, body circumferences such as chest, abdomen, hip, pelvis, mid-thigh circumference, etc., and skin fold thickness as biceps, triceps, mid-arm, and abdominal skinfold thickness.
doi:10.4103/0974-8520.127683
PMCID: PMC3968693  PMID: 24696569
Hyperlipidemia; Lekhana Basti; Triphala Guggulu
9.  Effect of Sameera Pannaga Rasa (arsenomercurial formulation) in the management of Tamaka Shwasa (bronchial asthma) - Randomized double blind clinical study 
Ayu  2013;34(4):346-351.
Asthma represents a profound world-wide public health problem. The most effective anti-asthmatic drugs currently available include β2-agonists and glucocorticoids which can controls asthma in about 90-95% of patients. In Ayurveda, this miserable condition is comparable with Tamaka Shwasa type of Shwasa Roga. In the present study, 52 patients were treated with Sameera Pannaga Rasa at a dose of 30 mg twice a day for 4 weeks along with Nagavallidala (leaf of Piper betel Linn.) The results were assessed in terms of clinical recovery, symptomatic relief, pulmonary function improvement and on subjective and objective parameters. A significant improvement in subjective parameters, control on asthma, recurrence of asthma, increase in peak expiratory flow rate, considerable decrease in total and absolute, acute eosinophil count and erythrocyte sedimentation rate were observed. Overall marked improvement was found in 33.33%, moderate improvement in 44.44% and mild improvement in 20.00% was observed. The study reveals that Sameera Pannaga Rasa can be used as an effective drug in bronchial asthma.
doi:10.4103/0974-8520.127692
PMCID: PMC3968694  PMID: 24696570
Bronchial asthma; pulmonary function; Sameera Pannaga Rasa; Shwasa
10.  Evaluation of diet and life style in the etiopathogenesis of Urdhwaga Amlapitta (non-ulcer dyspepsia) 
Ayu  2013;34(4):352-355.
For a long time, infectious (communicable) diseases were the biggest killer diseases globally. But now, the trend is changing toward increased prevalence of chronic diseases with causative factors mostly related to diet and lifestyle. Among them, Urdhwaga Amlapitta (non-ulcer dyspepsia), a gastrointestinal tract (GIT) disorder, has acquired majority of the share with causative factors like improper diet and habits, stress, spicy irritant food, oily foods, bakery products, etc., A survey study was conducted on 138 patients, irrespective of sex, religion, etc., who had presented with the clinical symptoms of Urdhwaga Amlapitta and attended the OPD of Department of Basic Principles, at I.P.G.T. and R.A., Gujarat Ayurved University, Jamnagar, between February 2009 and June 2010. Information on demography, dietary intake, and lifestyle factors was collected by standard questionnaires. The data revealed that majority of the patients indulged in faulty dietary habits like excess Katu Ahara Sevana (99.3%), Amla Ahara (95.65%), Guru Ahara (90.57%), Snigdha Ahara (86.23%), Viruddha (81.88%), Abhishyandi Ahara (81.88%), Atiushna Ahara (73.9%), Vidahi (51.44%), Pistanna (47.10%), etc., and the data on lifestyle revealed that majority of the patients indulged in Diwasvapna (89.85%), Antarodaka Paanam (81.88%), Chinta (79.71%), etc., This survey study upholds the novel concept of diet and lifestyle of Ayurveda. The data reflects that dietary patterns, lifestyle choices, and physical activities play an important role in the etiopathogenesis of Urdhwaga Amlapitta, and it is important for patients to have access to diet and lifestyle modifications. Currently, research in this area is minimal.
doi:10.4103/0974-8520.127705
PMCID: PMC3968695  PMID: 24695749
Diet; life style; non ulcer dyspepsia; Urdhwaga Amlapitta
11.  Scientific study of Charakokta Anguli Pramana in reference to human height 
Ayu  2013;34(4):356-360.
Ayurveda has dynamic and creative view on health and gives importance to the individual while managing his health and also during treating the diseases. Ayurveda is a system of health science which not only includes the knowledge of body and diseases but also includes the way of living healthy i.e., “Swastha”. The concept of Maana-Pramana is one of the significant contributions of Ayurveda. This study was undertaken to evaluate the Charakokta Sutra (verse) which implies that “Height (Aayama) of human being is 84 fingers (Anguli) and is equal to Arm Span (Vistaara)”. In the present study, anthropometric measurements by finger were taken and exact site of particular finger in a manner to execute “Anguli Sthana Nishchiti” was determined. The data of Aayama and Vistaara of the 100 volunteers was recorded and statistically analysed. After comparing the Anguli Pramana (Measurement through finger) obtained at 78 different sites of both hands, it was established that measurement of Anguli Pramana at the site of medio-lateral proximal interphalangeal joint of middle finger of right and left hand, would be most accurate in estimating Anguli Pramana.
doi:10.4103/0974-8520.127709
PMCID: PMC3968696  PMID: 24696571
Aayama-Vistaara; Anguli Pramana; anthropometry; human height
12.  Endoscopic evaluation of therapeutic effects of “Anuloma-Viloma Pranayama” in Pratishyaya w.s.r. to mucociliary clearance mechanism and Bernoulli's principle 
Ayu  2013;34(4):361-367.
The current endeavor intended to evaluate the effectiveness and mode of action of Anuloma-Viloma Pranayama (AVP), i.e., alternate nasal breathing exercise, in resolving clinical features of Pratishyaya, i.e., rhinosinusitis. The present study was directed to validate the use of classical “saccharin test” in measuring the nasal health by measuring mucociliary clearance time. This study also highlights the effects of AVP by application of Bernoulli principle in ventilation of paranasal sinuses and surface oxygenation of nasal and paranasal sinuses ciliary epithelium. Clinically, endoscopically and radiologically diagnosed patients of Pratishyaya, i.e., rhinosinusitis, satisfying the inclusion criteria were selected to perform AVP as a breathing exercise regularly for 30 min every day in order to evaluate the effectiveness of AVP in resolving features of rhinosinusitis. Saccharin test was performed before and after completion of 40 days trial to assess the nasal ciliary activity, which has been proved to be directly related to the health of ciliary epithelium and nasal health overall as well. AVP may be regarded as a catalyst to conspicuously enhance ventilation and oxygenation of the paranasal sinuses and the positively effect the nasal respiratory epithelium by increasing better surface availability of oxygen and negative pressure in the nasal cavity itself.
doi:10.4103/0974-8520.127714
PMCID: PMC3968697  PMID: 24696572
Anuloma-Viloma Pranayama; Bernoulli principle; mucociliary clearance time; nitric oxide; Pratishyaya (rhinosinusitis) and saccharin test
13.  Clinical evaluation of Bilvadileha in the management of irritable bowel syndrome 
Ayu  2013;34(4):368-372.
Irritable bowel syndrome (IBS) is one of the most common conditions encountered in clinical practice but one of the least well understood. Symptoms of this disorder are chronic, sometimes severe and often respond poorly to treatment, resulting in reduced quality of life. There is no specific test for IBS, although diagnostic tests may be performed to rule out other problems. In present clinical trial 51 patients of IBS were registered out of which 46 patients completed the treatment. Bilvadileha was administered for the duration of 12 weeks. The therapy showed statistically significant improvement in all the clinical features of IBS as well as in the IBS severity score.
doi:10.4103/0974-8520.127717
PMCID: PMC3968698  PMID: 24696573
Ayurvedic management; Bilvadileha; irritable bowel syndrome
14.  Effect of selected Samana and Vicitra Pratyayarabdha Dravya w.s.r. to Vipaka 
Ayu  2013;34(4):373-378.
Concept of Arabdhata and Pratyayarabdhata is a unique concept of Ayurveda, which is related to the conjugation and configuration of Mahabhutas (penta elements). Every substance undergoes some changes during digestion and metabolism in terms of changes in its Panchabhautika composition. If substance retains its Panchabhautika composition throughout the digestion and metabolism, it is known as Samana Pratyayarabdhata and if Panchabhautika composition of substance becomes totally different after digestion and metabolism, it is known as Vicitra Pratyayarabdhata. The change in Panchabhautika composition of substance can be seen at the level of Vipaka (post-digestive effect) or Virya (potency), which are not found according to Rasa (taste) and hence the Karma (action) of substance becomes different from its Rasa. Therefore, four drugs were selected, two having Samana Pratyayarabdhata (Nimba and Vasa) and two having Vicitra Pratyayarabdhata (Bhumyamalaki and Shankhapushpi). Clinical study was carried out on 24 healthy volunteers having Madhyama Koshta, divided into four groups, one group for each drug. The effects of drugs were assessed according to their Vipaka on Koshta (Bowel habit) especially on stool and habit of defecation (Srishtavinmutrata or Baddhavinmutrata). All the drugs showed effect according to their Vipaka in few parameters, but most of the results were statistically insignificant which suggested that substances perform their action according to their Pratyayarabdhata.
doi:10.4103/0974-8520.127718
PMCID: PMC3968699  PMID: 24696574
Samana Pratyayarabdha; Vicitra Pratyayarabdha; Vipaka
15.  Clinical study to evaluate the effect of Virechanakarma on serum electrolytes 
Ayu  2013;34(4):379-382.
Panchakarma therapy aims at the elimination of excessive Doshas from the body to maintain the state of health for a longer duration, while the Shamana therapy is for suppression of vitiated Doshas within the body. Virechana is one of the Panchakarma therapies wherein purgation is induced by drugs and it specifically aims at the elimination of excessive Pitta Dosha from the body. Normally, after Virechanakarma, patient does not complain of having any untoward like those present after diarrhea due to dehydration. This study was conducted to evaluate the effect of Virechanakarma on serum electrolyte levels and to ascertain the safety of therapeutic purgation. This study involved estimation of serum electrolyte levels before and after Virechana in 15 patients and the results are suggestive of safe application of the Virechana therapy as the deviation in electrolyte levels were within the normal range.
doi:10.4103/0974-8520.127719
PMCID: PMC3968700  PMID: 24696575
Electrolytes level; therapeutic purgation; Virechanakarma
16.  Effects of Medhya Rasayana and Yogic practices in improvement of short-term memory among school-going children 
Ayu  2013;34(4):383-389.
Excellent memory, extraordinary intelligence, great academic achievement, and successful career are the dreams of every individual in this era of competition and professionalism. A good memory power acts as a catalyst in all walks of life, be it academic success or maintenance of personal relationships. It is observed that an average man uses only 10% of his natural memory. Remaining 90% is left unused in a haphazard manner. As per the American psychologist Carl Emil Seashore, if one is alert and makes systematic attempts to awaken and use the natural memory properly, his/her natural memory would be activated creatively and would offer benefits of higher order. A comparative study was conducted comprising 90 subjects to know the efficacy of Medhya Rasayana and Yogic practices in short-term memory of school-going children. The study was conducted over a period of 3 months. It was an open, prospective, and randomized clinical study. The subjects of group A formed the control group and they were observed silently for 3 months without any intervention. The subjects in group B were administered with Choorna (powder) of four Medhya Rasayanas, Mandukaparni (Centella asiatica Linn.), Yashtimadhu (Glycyrrhiza glabra Linn.), Guduchi [Tinospora cordifolia (Willd.) Miers ex Hook. f. and Thoms.], and Sankhapushpi (Convolvulus pluricaulis Choisy), at a dose of 2 g twice daily with milk. Subjects belonging to group C were advocated regular Yogic practices of Asanas, Pranayama, and Dhyana. Further study revealed that among the three groups, group B treated with Medhya Rasayana showed highly significant and most effective changes with respect to objective parameters in the tests, i.e. (1) short-term memory test pictures and (2) serial recall effects test using memory scope. Among the three groups, group C treated with Yogic practices showed highly significant and most effective changes with respect to subjective and objective parameters in mini mental status scale i.e. test 3. The treatment is cost effective and devoid of side effects, which can be beneficial for the community. Mean increase after first follow-up in group B was higher as compared to group C. This shows that Medhya Rasayanas are quick in action and bring about improvement in memory faster when compared with Yogic practices. So, on the whole, group B can be considered to be the most efficient among the three groups.
doi:10.4103/0974-8520.127720
PMCID: PMC3968701  PMID: 24695779
Medhya Rasayana; school children; short term memory; Yogic practices
17.  A clinical study on the role of Agnimanthadi compound and Vashpa Svedana in the management of Sthaulya (obesity) 
Ayu  2013;34(4):390-396.
Currently more than 1 billion adults are overweight (Sthula) and at least 300 million of them are clinically obese. Obesity leads to adverse metabolic effects on blood pressure, cholesterol, triglycerides, and insulin resistance. Present study was planned to assess the role of Agnimanthadi compound containing Agnimantha, Mustaka, Gomutra (cow's urine), and Eranda Patra Kshara and Vashpa Svedana (VS) (generalized steaming) in the management of obesity. 80 patients of Sthaulya (obesity) were selected out of which 67 completed the treatment and they were treated in two groups. Amongst these, 38 patients were treated with Agnimanthadi compound in the dose of 2 gram (four capsules of 500 mg) 3 times a day with lukewarm water before meal and remaining 29 patients were given VS only. The duration of treatment in both groups was 7 weeks with follow-up for 2 months after the completion of treatment. Analysis of the overall effects of both the groups showed that VS provided marked reduction in weight, body mass index, and other signs and symptoms in patients of Sthaulya in comparison to the Agnimanthadi treated group.
doi:10.4103/0974-8520.127721
PMCID: PMC3968702  PMID: 24696576
Agnimanthadi compound; obesity; Sthaulya; Vashpa Svedana
18.  Comparative effect of Navayasa Rasayana Leha and Medhya Rasayana tablet along with Dhatryadhyo Lepa in Ekkakushta (psoriasis) 
Ayu  2013;34(3):243-248.
All skin diseases can be included under the umbrella of Kushta Roga. Ekkakushta is a variety of Kshudra Kushtha with dominancy of Vata and Kapha Doshas. It is characterized by symptoms like- Aswedanam, Mahavastum, Matsyashakalopamam, etc., these characteristic features has a striking similarity with Psoriasis. It is a papulosqaumous disorder of the skin, characterized by sharply defined erythmatosqaumous lesion. Due to its chronic and recurrent nature, it has a great impact on the quality of life of the patients. The present study was aimed to compare the effect of Navayasa Rasayana Leha and Medhya Rasayana tablet along with Dhatryadhyo Lepa in patients of Ekkakushta (psoriasis). For this study, the selected patients were randomly divided into two groups. Koshtha Shuddhi was done by Eranda Bruhstha Haritaki (6 g-at night with Ushnodaka) in patients of both the groups for 3 days before starting the treatment. Total 111 patients were selected for present study. Patients of group A (45 patients) were given “Navayasa Rasayana Leha” and “Dhatryadhyo Lepa” for external application. Stress is a very well known precipitating factor of Psoriasis. Hence, to study the efficacy of Medhya Rasayana drugs, patients of group B (49 patients) were given Medhya Rasayana tablet along with the external application of Dhatryadhyo Lepa. The duration of the study was 3 months with follow up for one month. Both the groups showed highly significant results in all signs, symptoms and other parameters. Navayasa Rasayana Leha and Medhya Rasayana tablet along with Dhatryadhyo Lepa can be used effectively for the treatment of Ekkakushta.
doi:10.4103/0974-8520.123103
PMCID: PMC3902587  PMID: 24501516
Ekkakushta; Psoriasis; Navayasa Rasayana Leha; Dhatryadhyo Lepa; Medhya Rasayana tablet
19.  Clinical evaluation of Veerataru (Dichrostachys cinerea Linn.) in the management of Mootrakruchchhra (Dysuria) 
Ayu  2013;34(3):249-253.
Veerataru is quoted to be effective in various conditions of Mootravaha Srotodushti such as Mootrakruchchhra (Dysuria), Mootraghata (Anuria), Ashmari (Urinary calculi), Sharkara (Concretions) etc., by various Acharyas. Mootrakruchchhra (Dysuria) is a disease of Basti (Bladder). It comes under Mootraapravruttijanyavyadhi, where Kruchchhrata (Shoola –Pain and Daha-Burning) during mootra pravrutti is the chief symptom. As per modern view, dysuria is a leading feature of lower or mid urinary tract infection. Antibiotics have their own limitations due to re-infections and recurrence even after long-term therapy, due to development of resistance of the microorganisms to the drugs. By considering all the above facts and to fulfill the lacuna about the absence of scientific data of Veerataru, the present research work had been taken up especially to evaluate its efficacy on Mootrakruchchhra (Dysuria). Patients suffering from Mootrakruchchhra (Dysuria) were selected and divided into two groups, i.e. Group A received Kwatha (decoction) of Veerataru-Dichrostachys cinerea Linn. (Trial drug) and Group B received Kwatha of Punarnava-Boerhaavia diffusa Linn. (Standard control) respectively. The effects of therapy were assessed by a specially prepared clinical research proforma. The result showed better symptomatic relief in Group A, i.e. trial drug as compared to Group B, i.e. standard control group.
doi:10.4103/0974-8520.123105
PMCID: PMC3902588  PMID: 24501517
Mootrakruchchhra; Veerataru (Dichrostachys cinerea Linn.); Mootravaha Srotodushti
20.  Clinical study on the effect of decoction of Pavetta indica Linn. in treatment of Purishaja Krimi with special reference to Enterobius vermicularis infestation 
Ayu  2013;34(3):254-258.
Pavetta indica Linn. (Family: Rubiaceae; Sanskrit name: Papata) is 2-5 m tall, shrub or small tree with opposite branches and grows in the Asia - Pacific region including Sri Lanka. Purishaja Krimi is one of the worm infestations described in Ayurveda. Enterobius vermicularis is among the most common of worms affecting children and adults. E. vermicularis is considered as one type of Purishaja Krimi. Sri Lankan traditional and ayurvedic physicians use P. indica to treat different ailments including Purishaja Krimi (E. vermicularis) infestations successfully. Since no scientific studies have been undertaken to study these effects so far, the present clinical study was carried out to evaluate the effect of P. indica in treatment of E. vermicularis infestation. Fifty patients between age of 5 and 12 years (Group A and B) and 50 patients between 13 and 65 years (Group C and D) with symptoms of E. vermicularis infestations such as itching in the anal region, impaired appetite, abdominal pain, eructation, diarrhea or constipation and presence of ova in stools were selected. Two decoction of the trail drug with different concentration was prepared. Group A and Group B were treated with 60 ml of decoction 1 and 60 ml of placebo respectively, twice daily for 14 days. Group C and Group D were treated with 120 ml of decoction 2 and 120 ml of placebo respectively, twice daily for 14 days. Groups A and C showed complete or partial reduction of symptoms, that is; itching in the anal region, impaired appetite, abdominal pain, eructation, diarrhea and also ova of E. vermicularis were absent in stools after treatment with P. indica. Decoction of P. indica can be recommended as an effective treatment for Purishaja Krimi (E. vermicularis infestation).
doi:10.4103/0974-8520.123110
PMCID: PMC3902589  PMID: 24501518
Enterobius vermicularis; Pavetta indica; Purishaja Krimi; thread worm
21.  Evaluation of biophysical parameters of Amrutapatolaksheeravasti Dravya and Karma - An observational study 
Ayu  2013;34(3):259-262.
The study aims to observe the effects of Amrutapatolaksheeravasti Dravya (medicated milk enema) in values of biophysical-chemical parameters. The classical Vasti (enema) can be analyzed with the help of biophysical parameters like pH, temperature, and specific gravity (Sp.gr.). Three hundred samples of classically prepared Amrutapatolaksheeravasti were analyzed for pH, temp., Sp.gr. with the calibrated instruments before each Vastikarma. The clinical symptoms based on proper Vastikarma and its complication were recorded and assessed. The parameters - pH, temperature, Sp.gr., and viscosity have shown a significant to highly significant value of correlation coefficient “r” and ‘t’ in relation to successful Vastikarma and retention time of Vasti Dravya respectively. pH <5.8 and temperature >39°C led to anal irritation in Ksheera Vasti. Similarly, pH >6.1 and temperature <32°C resulted in flatulence. The effects of pH and Sp.gr. are due to temperature as both are temperature-based variables.
doi:10.4103/0974-8520.123112
PMCID: PMC3902590  PMID: 24501519
Biophysical parameters; standardization; Vastikarma
22.  Comparative study of Vamana and Virechanakarma in controlling blood sugar levels in diabetes mellitus 
Ayu  2013;34(3):263-269.
Diabetes mellitus (DM) with its devastating consequences is a global health problem of this era. Presently India is having the largest diabetic population of 50.8 million. The characteristic features of DM have close resemblance with Prameha (obstinate urinary disorders including diabetes) in Ayurveda. Madhumeha is a Vatika subtype of Prameha that is most close to DM. One variety of this Madhumeha (DM) is Aavaranjanya (due to occlusion) in which Vayu aggravates due to occlusion by Pitta or Kapha. This type of Madhumeha (DM) can be managed if Samshodhana (bio-cleansing) is used in early stages of disease followed by palliative treatment. Vamana (emetic therapy) and Virechana (purgation therapy) are the Samsodhana Karma (bio-cleansing therapies) that are compatible to overcome this Aavarana (occlusion). A comparative study was planned to compare their efficacy in controlling blood sugar levels in patients with DM. Although none of them were completely able to control blood sugar in the long-term but the study yields some very interesting results in reducing the blood sugar levels which could be useful in the future studies related to DM.
doi:10.4103/0974-8520.123115
PMCID: PMC3902591  PMID: 24501520
Blood sugar control; Prameha; Vamana; Virechana
23.  Efficacy of Yoga for sustained attention in university students 
Ayu  2013;34(3):270-272.
Sustained attention (SA) is a vital function mediated by the right frontal - parietal cortex. The digit vigilance test (DVT) measures SA. Assessment of SA in students for their academic excellence is considered to be an essential part of a neuropsychological evaluation. The objective of this study is to determine SA in students undergoing training of integrated Yoga module (IYM). A total of 66 university students aged between 18-37 years participated in this study with a single group pre-post design. The DVT data was collected before and after the IYM. Statistical Package for Social Sciences version 19 was used for data analysis. The Kolmogorov-Smirnov test showed that the data were not normally distributed. The Wilcoxon's signed ranks test was used to compare means of data. The data analysis showed 11.66% decrease (P < 0.001) in total time taken for DVT and 31.90% decrease (P < 0.001) in error scores for DVT. The present study suggests that IYM can result in improvement of SA among students, thus paving the way for their academic excellence. Additional well-designed studies are needed before a strong recommendation can be made.
doi:10.4103/0974-8520.123117
PMCID: PMC3902592  PMID: 24501521
Academic excellence; integrated Yoga module; sustained attention; university students
24.  Clinical evaluation of root tubers of Shweta Musali (Chlorophytum borivilianum L.) and its effect on semen and testosterone 
Ayu  2013;34(3):273-275.
Shweta Musali (Chlorophytum borivilianum (CB)) is a traditionally used herb for its benefits in male sexual and general health. In the recent past, the herb has attained much commercial significance, both in domestic and international markets. However, limited clinical data is available to establish its traditional claims. The present study was aimed at evaluating the effect of the water soluble extract of CB root tubers on semen and testosterone in healthy adult males. The research was designed as a randomized, double-blind, placebo-controlled, trial upon the volunteers registered from the outpatient department (OPD) with age ranging from 20 to 40 years. Water extracts of CB and placebo was administered in the patients of groups A and B, for 12 weeks, in two divided doses of 500 mg. Assessment was done based upon Semen (Volume, Liquefaction Time, Sperm Count, Sperm motility) and Serum Testosterone levels parameters. Highly significant improvement was noted in the above parameters after administration of CB extract in comparison to Placebo. Hence it was concluded that the trial drug was effective in improving male sexual health.
doi:10.4103/0974-8520.123118
PMCID: PMC3902593  PMID: 24501522
Chlorophytum borivilianum; Shweta Musali; semen; testosterone
25.  A comparative study on the effect of Pandughnivati and Dhatrilauhavati in the management of Garbhinipandu (Iron Deficiency Anemia) 
Ayu  2013;34(3):276-280.
The desire to have a healthy progeny is innate and very intense in every livingbeing. The hectic life and tremendous stress in daily life has made the conception and continuation of pregnancy till term very difficult. Anemia is one of the common disease conditions, which affects a pregnant woman. In Ayurvedic classics anemia in pregnancy is taken under the Rasa Pradoshajavikara. It is clear that Garbhavasthajanyapandu occurs due to the fetal demands and improper functioning of the Rasadhatu leading to malnourishment of the body. A total of 26 patients were registered from out-patient department of Streeroga and Prasutitantra, out of which four patients discontinued. The remaining 22 patients were randomly divided into two groups; Group A (n-12) Pandughnivati two tablets of 500 mg tds and Group B (n-10) Dhatrilauhavati one tablet of 500 mg tds. Dhatrilauhavati was selected for the present study due to its Pandughna, Prinana, Raktaprasadana properties. In the present study, Pandughnivati a compound formulation developed by AYUSH department was administered for patients of group A. The results revealed that the over all clinical improvement was better in patients of Group B when compared to Group A. Hence it was concluded that Dhatrilauhavati was effective in treating anemia during pregnancy.
doi:10.4103/0974-8520.123120
PMCID: PMC3902594  PMID: 24501523
Anemia in pregnancy (iron deficiency anemia); Dhatrilauhavati; Garbhinipandu; Pandughnivati

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