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1.  Subclinical haemorrhagic tendency exists in patients with β-thalassaemia major in early childhood 
The Australasian Medical Journal  2012;5(2):152-155.
Background
Alterations of coagulation profile have been reported in patients with β-thalassaemia major (β-TM).
Method
To investigate this in the paediatric population, we studied haemostatic parameters in pre-transfusion blood samples from 50 non-splenectomised transfusion-dependent children with β-TM (mean age 6±2.5 years) and in blood from 25 healthy controls.
Results
Laboratory evaluation showed thrombocytopenia in 40%, prolongation of prothrombin time (PT) in 12% and prolongation of activated partial thromboplastin time (APTT) in 6% of the patients. Mean values for PT, APTT and platelet count (PC) were all raised in the patient population compared with the controls. The alteration of coagulation status was significant for PT (p value <0.005) and APTT (p value <0.0001). However, the change for PC was not significant (p value <0.05). No significant liner correlation could be identified between PT, APTT, PC of the patients and interval between transfusions (in days) or days since last transfusion.
Conclusion
The findings from this study suggest that a subclinical haemorrhagic tendency exists in patients with β-TM at a very early age. The intrinsic pathway appears to be more affected than the extrinsic pathway.
doi:10.4066/AMJ.20121076
PMCID: PMC3413934  PMID: 22905058
Thalassaemia Major; Haemorrhage; Coagulation; Prothrombin Time; Activated Partial Thromboplastin Time

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