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1.  Peptide nucleic acid probes with charged photocleavable mass markers 
Artificial DNA, PNA & XNA  2010;1(1):27-35.
Halogen-labelled peptide organic acid (HPOA) monomers have been synthesised and incorporated into sequence-specific peptide nucleic acid (PNA) probes. Three different types of probe have been prepared; the unmodified PNA probe, the PNA probe with a mass marker, and the PNA probe with photocleavable mass marker. All three types of probe have been used in model studies to develop a mass spectrometry-based hybridisation assay for detection of point mutations in DNA.
doi:10.4161/adna.1.1.12199
PMCID: PMC3109446  PMID: 21687524
peptide nucleic acid; photocleavable mass marker tag; genetic analysis; halogen-labelled peptide organic acid; SNP

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