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1.  Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration 
Arthritis Research  2001;3(6):389-394.
Weight loss is typically found during severe infections, e.g. septic arthritis. The aim of our study was to evaluate the role of leptin, regulator of food intake and energy expenditure, for the development of Staphylococcus aureus-triggered arthritis. Leptin production was found to be decreased during murine S. aureus-induced arthritis. Treatment with recombinant leptin neither restored the basal leptin levels nor affected the weight loss during the disease, but it significantly decreased the severity of septic arthritis. Exogenous leptin did not affect the staphylococcal load as measured in blood, joints and kidneys. Preceding the effects on joint manifestations, serum levels of interleukin-6 decreased in leptin-treated mice. In conclusion, the treatment with recombinant leptin reduced both the severity of joint manifestations in S.aureus-induced arthritis and the inflammatory response, as measured by serum IL-6 levels, without affecting the survival of bacteria in vivo.
PMCID: PMC64851  PMID: 11714394
arthritis; interleukin-6; leptin; Staphylococcus aureus
2.  Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis 
Arthritis Research  2000;3(1):41-47.
The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-╬│ in IL-12-deficient mice. Although IL-12-deficient mice were exposed to higher staphylococcal load, they demonstrated no increased severity of arthritis as compared with control animals.
PMCID: PMC17823  PMID: 11178125
IL-12; septic arthritis; Staphylococcus aureus

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