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1.  Staphylococcal peptidoglycans induce arthritis 
Arthritis Research  2001;3(6):375-380.
Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN), highly purified PGN from S. aureus was intra-articularly injected into murine joints. The results demonstrate that PGN will trigger arthritis in a dose-dependent manner. A single injection of this compound leads to massive infiltration of predominantly macrophages and polymorphonuclear cells with occasional signs of cartilage and/or bone destruction, lasting for at least 14 days. Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus.
PMCID: PMC64849  PMID: 11714392
arthritis; peptidoglycan; Staphylococcus aureus
2.  Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA 
Arthritis Research  2000;3(1):48-53.
Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation.
PMCID: PMC17824  PMID: 11178126
arthritis; CpG dinucleotides; cytokine; IL-12 knockout

Results 1-2 (2)