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1.  Morphological Alterations of Pseudomonas aeruginosa by Ticarcillin: a Scanning Electron Microscope Study 
Pseudomonas aeruginosa was exposed to 0.1, 1.0, 10, 100, and 1,000 times the minimal inhibitory concentration of ticarcillin in vitro and subsequently examined with the scanning electron microscope. The morphological alterations observed were filamentation, mid-cell defects, and spheroplast formation, and these alterations were dependent upon the drug concentration.
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PMCID: PMC444749  PMID: 4218072
4.  Mutagenic Activity of Diazoacetylglycine Derivatives 
Some diazoacetyl derivatives of glycine known as antitumor and immunosuppressive agents have been found to be powerful mutagens of the base substitution type.
PMCID: PMC444711  PMID: 15825324
5.  Microbiological Assays and Bioautography of Maytansine and Its Homologues 
A quantitative microbiological assay and a bioautography system with Penicillium avellaneum UC-4376 was developed for the antitumor drugs maytansine, and its homologues, maytanprine and maytanbutine. The susceptibility of the assay is 1.5 μg/ml.
PMCID: PMC444709  PMID: 15825322
6.  Inhibition of Herpesvirus Replication by Marine Algae Extracts 
Extracts from two species of marine red algae, Cryptosyphonia woodii and Farlowia mollis, specifically inhibited herpes simplex virus replication in vitro.
PMCID: PMC444684  PMID: 4157357
7.  Antimicrobial Activity of the Volatile Oil of Nigella sativa Linneaus Seeds 
The antimicrobial activity of the volatile oil of Nigella sativa Linneaus seeds was studied. The antimicrobial principle has been isolated, identified as thymohydroquinone, and found to be active against gram-positive bacteria and yeasts.
PMCID: PMC444630  PMID: 15828195
10.  In Vitro Susceptibility of Haemophilus influenzae to Eight Antibiotics 
Freshly isolated strains of Haemophilus influenzae type B were studied for their in vitro susceptibility to eight antibiotics with a low concentration inoculum. No organisms were identified as being resistant to ampicillin, but minimal inhibiting concentrations for that antibiotic were somewhat higher than reported previously for a similar method. Carbenicillin and ticarcillin resembled ampicillin in activity, and the three agents were more effective on a weight basis than the other agents tested.
PMCID: PMC429055  PMID: 15828179
12.  BRL.8988 (Talampicillin), a Well-Absorbed Oral Form of Ampicillin1 
The phthalidyl ester (BRL.8988, talampicillin) of ampicillin gave serum levels in man two and a half times those obtained with ampicillin itself.
PMCID: PMC429033  PMID: 15825424
14.  Effect of Carbon Dioxide on Synthesis of Erythromycin 
Erythromycin synthesis was markedly impaired in submerged cultures under high carbon dioxide tensions. Growth of Streptomyces erythreus, however, was unaltered by increased carbon dioxide.
PMCID: PMC429009  PMID: 4462468
18.  Expression of R Factor-Mediated Resistance to Tetracycline in Escherichia coli Minicells 
The induction and expression of tetracycline resistance in R+ minicells from Escherichia coli is incomplete, suggesting that some chromosomally mediated function is necessary for the full expression of tetracycline resistance.
PMCID: PMC428943  PMID: 4599118
19.  Double-Blind Comparison of Phlebitis Produced by Cephalothin Infusions with Buffered and Unbuffered Diluents 
In a double-blind study with each patient as his own control, a buffered and an unbuffered cephalothin solution was administered to 13 patients in opposite arms for a period of 48 h each. Neither the incidence of phlebitis nor the degree of phlebitis was different with the two diluents, and there was no difference in the time of onset of phlebitis.
PMCID: PMC428942  PMID: 4840431
20.  Administration of Ticarcillin, a New Antipseudomonal Antibiotic, in Patients Undergoing Dialysis 
Ticarcillin was administered to three groups of patients in chronic renal failure; three were undergoing chronic hemodialysis, two were undergoing peritoneal dialysis, and three received the drug after hemodialysis. The serum half-lives were measured. A dosage regime for patients undergoing dialysis is suggested.
PMCID: PMC428932  PMID: 4840427
21.  Lysis of Enterococcal L-Forms by Phenylethyl Alcohol 
Enterococcal L-forms were lysed by phenylethanol, as shown by turbidimetric analysis and electron microscopy.
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PMCID: PMC428927  PMID: 4840452
22.  Quantitative Assay of Pyrazofurin a New Antiviral, Antitumor Antibiotic1 
Pyrazofurin, a carbon-linked nucleoside, has been previously reported to possess antiviral and antitumor activity. The antagonistic effect of pyrazofurin against Neurospora crassa has been utilized to develop a quantitative assay for the compound.
PMCID: PMC428924  PMID: 4275616
23.  In Vitro Studies with Cefazolin 
Susceptibilities of 259 isolates of pathogenic bacteria to cefazolin were measured by broth and agar dilution procedures. Beta-hemolytic streptococci were inhibited by 0.25 μg/ml, whereas Staphylococcus aureus and alphahemolytic streptococci were inhibited by 2.0 μg/ml. Enterococci were resistant to less than 32 μg/ml. Wide variation was seen with gram-negative species. Most isolates of Klebsiella species and Proteus mirabilis were inhibited by 4.0 or 8.0 μg/ml. Escherichia coli were less susceptible, and most isolates of Pseudomonas aeruginosa, Serratia species, and Enterobacter species were resistant to 128 μg/ml.
PMCID: PMC444750  PMID: 4451358
24.  Studies on the Regulation of Colicin Ib Synthesis: Replication of the Col Ib-P9 Plasmid During Colicin Induction 
The Col Ib-P9 plasmid content of colicinogenic cells has been measured by both sedimentation analysis of cleared lysates and by deoxyribonucleic acid hybridization to purified Col Ib-P9 factor deoxyribonucleic acid. The results show an independence between mitomycin C-induced colicin synthesis and Col Ib-P9 replication. In addition, the ratio of the various molecular configurations (i.e., covalently closed circles or open circles) of the Col Ib-P9 plasmid does not change upon induction of colicin synthesis. Heat treatment of a colicinogenic strain carrying a thermosensitive dnaB mutation on the bacterial chromosome leads to complete inhibition of Col Ib-P9 plasmid replication and the simultaneous induction of colicin Ib synthesis in all cells of the colicinogenic population. These studies rule out mechanisms or regulation of colicin Ib synthesis based on the induced replication of the Col Ib-P9 plasmid. Our studies show that in a Col Ib-P9 colicinogenic population there is, on the average, one plasmid per cell.
PMCID: PMC444748  PMID: 4451357
25.  Properties of R Factors from Bordetella bronchiseptica 
Genetic properties and host ranges of R factors derived from Bordetella bronchiseptica of pig origin were examined. All of 61 R factors tested could confer resistance to streptomycin, sulfonamide, and aminobenzyl penicillin on their host bacteria. All of them were identified as fi− (no fertility inhibition) type and were found to exhibit no restriction of phages λ, φ80, P1, P2, T1, T3, T6, T7, W31, and BF-23. They could confer macarbomysin susceptibility on their host cells when infected. An Rte16, a representative R factor, was incompatible with both RP4 and R40a, which are classified as compatibility groups P and C, respectively. An Rte16 was conjugally transmissible to B. bronchiseptica, Escherichia coli, Citrobacter freundii, Salmonella typhimurium, and Yersinia enterocolitica, but not to Shigella flexneri, S. sonnei, Proteus mirabilis, P. vulgaris, P. rettgeri, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
PMCID: PMC444746  PMID: 4451355

Results 1-25 (281)