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11.  Semiautomated Turbidimetric Bioassay for the Ionophore A23187 
The inhibitory effect of A23187 against Staphylococcus aureus was used to quantitate the activity of this ionophore in fermentation samples and in isolation and crystallization samples. The assay was shown to be rapid and reproducible.
PMCID: PMC352098  PMID: 327922
21.  Polymyxin B and Rifampin: New Regimen for Multiresistant Serratia marcescens Infections 
Polymyxin B and rifampin were given to 12 patients with multi-drug-resistant nosocomial Serratia marcescens infections. Eight cures were achieved; drug hepatotoxicity occurred once; one fatal suprainfection was encountered; and two patients died during therapy of causes related to severe underlying illnesses. Polymyxin B and rifampin were uniformly synergistic in vitro against the infecting strains and against 40 additional clinical isolates of S. marcescens.
PMCID: PMC429999  PMID: 201214
22.  Quantitative Inhibition of Haemophilus influenzae by Trimethoprim/Sulfamethoxazole 
We evaluated the inhibitory effect of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination, against 34 strains of Haemophilus influenzae. Growth inhibition was determined after incubation for 18 h by comparing viable counts of cultures in drug-containing medium with corresponding counts of control cultures in drug-free medium. In a modified, thymidine-deficient Levinthal broth, the numbers of colony-forming units of all the isolates tested were reduced 100-fold or more by TMP/SMZ (1.25/25 μg/ml) as compared with growth without drug. Inhibition was significantly greater with TMP/SMZ than with either TMP or SMZ alone. Ampicillin-susceptible and ampicillin-resistant strains were equally susceptible to TMP/SMZ. Growth of nontypable strains was inhibited more than growth of type b organisms.
PMCID: PMC429998  PMID: 303886
23.  Methadone: Antimicrobial Activity and Interaction with Antibiotics 
We studied the effect of methadone, alone and in combination with antimicrobial agents, on two strains each of Staphylococcus aureus, Pseudomonas aeruginosa, and Serratia marcescens isolated from blood streams of parenteral drug abusers with bacterial endocarditis. Methadone has its own antibacterial effect, although at supraphysiological concentrations, and is even synergistic with antimicrobial agents against some organisms. Thus, methadone does not interfere with the antibacterial effects of antibiotics in vitro.
PMCID: PMC430016  PMID: 412466
24.  Penicillins Activate Autolysins Extracted from Both Escherichia coli and Klebsiella pneumoniae Envelopes 
Ampicillin at a 50-μg/ml concentration effects a doubling of the autolysis rate of cell envelopes isolated from Klebsiella pneumoniae Mir A12. This antibiotic increases also by two- to threefold the depolymerizing activity of both K. pneumoniae and Escherichia coli crude extracts on a labeled peptidoglycan-lipoprotein complex. Several other penicillins also activate autolysins.
PMCID: PMC430015  PMID: 337892
25.  Pharmacokinetics of Cefaclor in Normal Subjects and Patients with Chronic Renal Failure 
We studied the pharmacokinetics of cefaclor, a new cephalosporin antibiotic, in normal subjects and subjects with chronic renal failure. Cefaclor was largely, but not entirely, eliminated by the kidneys. The cefaclor half-life in normal subjects was 40 to 60 min; in subjects with essentially no renal function, it increased to 3 h. In normal subjects, 50 to 70% of a 250-mg dose was excreted in the urine within 8 h. The linear relationship between the elimination constant and creatinine clearance allowed the construction of a useful dosage modification nomogram.
PMCID: PMC430012  PMID: 931372

Results 1-25 (366)