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1.  Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient 
Annals of Saudi Medicine  2010;30(5):404-407.
Carbapenemase-producing Klebsiella pneumoniae infections carry serious clinical and infection-control implications. Isolates possessing such hydrolyzing enzymes have been described in the United States and around the world. Besides being resistant to carbapenems, they usually confer resistance to fluoroquinolones, piperacillin-tazobactam, and extended-spectrum cephalosporins. Tigecycline demonstrates in vitro activity against these organisms, but reported resistance raises concern about tigecycline use for these infections. We describe a carbapenemase-producing K pneumoniae evolving resistance to tigecycline in a 75-year-old male after a prolonged stay in a critical care unit.
doi:10.4103/0256-4947.67087
PMCID: PMC2941256  PMID: 20697161

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