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1.  Acute posterior circulation infarct due to bicuspid aortic valve vegetation: An uncommon stroke mechanism 
Acute ischemic stroke may be the first clinical manifestation of the underlying cardioembolic source. We are reporting a 28-year-old man presenting with acute posterior circulation infarct due to underlying bicuspid aortic valve disease with vegetation detected by transesophageal echocardiography in the absence of clinical features of heart disease and infective endocarditis. The case report highlights the importance of routine evaluation of cardioembolic sources in all cases of ischemic stroke.
PMCID: PMC3644766  PMID: 23661975
Bicuspid aortic valve vegetation; posterior circulation infarct; stroke in young
2.  Use of thrombolytic therapy in cerebral venous sinus thrombosis with ulcerative colitis 
Cerebral venous thrombosis developing concurrently with active ulcerative colitis poses a therapeutic dilemma. We report the case of a 31-year-old woman who developed dural venous sinus thrombosis during the course of active ulcerative colitis in whom we accomplished clot lysis using intrasinus urokinase. The success of the procedure was assessed by improvement in the patient's neurological condition and resolution of imaging features without any bleeding complications. We also reviewed literature on various modalities of treatment of sinus venous thrombosis in patients with ulcerative colitis and outcome.
PMCID: PMC3299069  PMID: 22412271
Cerebral venous sinus thrombosis; intrasinus urokinase; thrombolytic therapy; ulcerative colitis
3.  Stroke management 
Annals of Indian Academy of Neurology  2011;14(Suppl1):S82-S96.
PMCID: PMC3152174  PMID: 21847335
4.  Vascular cognitive impairment: Current concepts and Indian perspective 
Annals of Indian Academy of Neurology  2010;13(Suppl2):S104-S108.
Cognitive impairment due to cerebrovascular disease is termed “Vascular Cognitive Impairment” (VCI) and forms a spectrum that includes Vascular Dementia (VaD) and milder forms of cognitive impairment referred to as Vascular Mild Cognitive Impairment (VaMCI). VCI represents a complex neurological disorder that occurs as a result of interaction between vascular risk factors such as hypertension, diabetes, obesity, dyslipidemia, and brain parenchymal changes such as macro and micro infarcts, haemorrhages, white matter changes, and brain atrophy occurring in an ageing brain. Mixed degenerative and vascular pathologies are increasingly being recognised and an interaction between the AD pathology, vascular risk factors, and strokes is now proposed. The high cardiovascular disease burden in India, increasing stroke incidence, and ageing population have contributed to large numbers of patients with VCI in India. Inadequate resources coupled with low awareness make it a problem that needs urgent attention, it is important identify patients at early stages of cognitive impairment, to treat appropriately and prevent progression to frank dementia.
PMCID: PMC3039170  PMID: 21369414
Dementia; stroke; vascular cognitive impairment

Results 1-5 (5)