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1.  A comparative pharmacognostical evaluation of two Artemisia species found in Nilgiris biosphere 
Ancient Science of Life  2007;27(2):7-13.
Artemisia pallens Wall. ex DC commonly known as “Davana” in Kannada and Artemisia abrotanum Linn. known as “Southernwood” (Asteraceae) are aromatic herbs, erect in habit, upto 60 cm tall, leaves are very small, much divided, bluish green. These plants find use in traditional systems of medicine viz., anthelmintic, tonic and antipyretic properties. Since, these species have not been scientifically evaluated; the present study was aimed to bring these plants under a suitable pharmacognostical scheme.
PMCID: PMC3330844  PMID: 22557262
2.  Analgesic activity of Justicia beddomei leaf extract 
Ancient Science of Life  2007;27(2):14-18.
The analgesic activity of ethanolic extract of Justicia beddome leaves (Family: Acanthaceae) was evaluated in albino rats using Eddy's hot plate method. The extract at 50 and 100 mg/ kg, (i.p), showed significant analgesic activity at 90 minutes of administration. The analgesic effect of the extract was comparable to that of morphine sulphate.
PMCID: PMC3330845  PMID: 22557263
3.  Hypoglycemic and Hypolipidemic effect of Coccinia indica Wight & Arn in alloxan induced diabetic rats 
Ancient Science of Life  2007;27(2):34-37.
Diabetes Mellitus is characterized by elevated plasma glucose concentrations resulting from insufficient insulin. The present study was aimed to investigate the hypolipidemic effect of Coccinia indica aqueous leaf extract in alloxan induced diabetic rats. The results of this study revealed that a continuous administration of Coccinia indica extract for 21 days prevents the elevation of the level of serum lipids secondary to the diabetes state
PMCID: PMC3330846  PMID: 22557267
Diabetes mellitus; Coccinia indica
4.  Comparative antimicrobial activities of Emblica officinalis and Ocimum sanctum 
Ancient Science of Life  2007;27(2):1-6.
The aqueous and successive extracts of the fruit pulp of Emblica officinalis and fresh leaves and stems of Ocimum sanctum were prepared and evaluated for antimicrobial activity. The successive extracts such as petroleum ether,chloroform, ethyl acetate and methanol were prepared by successive solvent extraction method and aqueous extract by maceration process and screened for antimicrobial activity against gram positive bacteria Staphylococcus aureus, gram negative bacteria E.coli and fungal strains of Candida species by using agar cup plate method. The extracts showed different degree of activity against pathogenic microbes. The results obtained were compared with standard drugs Amoxicillin (10μg) and Amphotericin B(10μg). The methanolic extract of Emblica officinalis was found to be more effective than the leaf and stem extracts of Ocimum sanctum in inhibiting all the microbial strains.
PMCID: PMC3330847  PMID: 22557261
5.  Effect of Syzygium calophyllifolium Walp. seed extract on transaminases and phosphatases in alloxan induced diabetic rats 
Ancient Science of Life  2007;27(2):28-33.
The antidiabetic effect of an aqueous seed extract of Syzygium calophyllifolium Walp. was studied in alloxan induced diabetic rats. Changes in serum and tissue AST, ALT LDH, ACP and ALP, enzymes activities in alloxan induced rats were studied and found to be reversed by the oral administration of S.calophyllifolium seed extract.
PMCID: PMC3330848  PMID: 22557266
6.  Netra darpanamu - A Unique book on eye diseases 
Ancient Science of Life  2007;27(2):44-49.
Netra Darpanamu is the only book written exclusively on Eye diseases in Telugu. This Ayurvedic book, which is famous in Andhra Pradesh, was first published in 1908 in Eluru. The book is written in chaste Telugu poetry, comprising the types of treatment followed by 36 recipes. This book contains names of various eye diseases, treatment procedures like bandages, plasters, collyriums and regimen of food and behaviour. This article aims to highlight the importance of this book in treating various eye diseases.
PMCID: PMC3330849  PMID: 22557269
7.  Pharmacological validation of Kantha chendooram for antiulcer activity in modified pylorus ligated (shay) rat model 
Ancient Science of Life  2007;27(2):38-43.
The use of metals and minerals is predominant in siddha system of medicine. As per siddha concept, peptic ulcer is known as Valigunmam, the basic abnormality appears to be the derangement of metabolism in the stomach and duodenum resulting in malfunctioning of the secretory process of gastric mucosa. Chendooram is a group of siddha drugs which is used for anemia, obesity, rheumatic diseases; abdominal tumours etc.During the present study standardized Kantha chendooram was selected and evaluated for its anti-ulcer activity, which could not be attempted by researchers earlier.
PMCID: PMC3330850  PMID: 22557268
Siddha drug Kantha Chendooram Anti-ulcer activity
8.  Effect of Semecarpus anacardium against lead induced toxicity in rats 
Ancient Science of Life  2007;27(2):24-27.
The present study was carried out to understand the antioxidant and protective effect of Semecarpus anacardium against lead acetate induced toxicity. This was done by analyzing the phytochemicals (Flavanoids, alkaloids, resins, tannins, carbohydrates, proteins, etc.) present in the plant and by assessing the hepatoprotective efficacy of the plant against lead acetate induced albino rats. Histopathological examination was also carried out to have a supporting evidence for the study. It was observed that the nut milk extract contains flavanoids, phenols and carbohydrates and the drug was effective against lead acetate induced toxicity. The levels of the marker enzymes were increased in the lead acetate induced rats and after the treatment of Semecarpus anacardium the liver damage decreased.
PMCID: PMC3330851  PMID: 22557265
Lead acetate; Male albino rats; Semecarpus anacardium; Hepatotoxicity
9.  Ethnomedicinal investigation in Nandurbar district of Maharasthtra 
Ancient Science of Life  2007;27(2):50-56.
The aborigines exploit medicinal virtues of tubers, roots fruits, seeds, flowers, leaves etc. from the forest and use in a variety of ways. The are used in the form of juice, decoction, oil, paste, extract, infusion and powder. Fresh parts are also used and the substances like sugar, sugarcandy, groundnut oil, milk and cow-ghee are used as additives. The native uses of medicinal plants are employed to better stomachcomplaints, rheumatic pains, spermatorrhoea, tooth-ache, head-ache, ear-ache, weakness, urinal troubles, fresh cuts, tumors, fever, mouth ulcer, bone fracture and few other human diseases. Total 47 species are being reported for the aforesaid ailments of these, applications of 32 species are unknown or little known. These are, however, desired for further scientific assessments for obvious reasons.
PMCID: PMC3330852  PMID: 22557270
Ethnomedicine; Nandurbar district; Maharashtra
10.  Diuretic activity of Nyctanthes arbortristis Linn. 
Ancient Science of Life  2007;27(2):19-23.
Nyctanthes arbortristis Linn. is a well documented plant. The present study is done to establish the diuretic activity of the water-soluble portions of the ethanolic extracts of its flowers, barks, seeds and leaves. In toxicity study, the extracts were seen to be safe up to the dose of 2.0 gm/kg. For the estimation of diuretic activity, the parameters studied were total urine volume and urine concentration of Na+, K+ and Cl-. The ethanolic extracts of different plant parts of Nyctanthes arbortristis L. possess significant diuretic activity as reflected by rise in urine volume with cation excretion. The ethanolic extracts of the seeds and leaves at their higher doses exhibited higher electrolyte excretion.
PMCID: PMC3330853  PMID: 22557264
Nyctanthes arbortristis L.; diuretic activity
11.  Anatomical features and histological studies on Cressa cretica Linn. 
Ancient Science of Life  2007;27(1):31-37.
The major diagnostic characters and histological studies on the leaf, root and stem of Cressa cretica L. has been reported in this paper. Literature survey showed the absence of any systematic authentication of this plant.
PMCID: PMC3330834  PMID: 22557257
12.  Antipyretic activity of Radix paeoniae 
Ancient Science of Life  2007;27(1):14-18.
The acetone extracts of Radix paeoniae (Paeonaceae) root (100 and 200 mg/kg orally) were tested in brewer's yeast-induced pyrexia in rats to assess their antipyretic activity. The pyrexia in rats was reduced significantly (P < 0.05) compared to that of control. These results indicate that the extracts possess antipyretic properties. The root extract showed significant reduction in normal body temperature and yeast-provoked elevated temperature comparable to that of standard antipyretic drug paracetamol. The antipyretic effect was started at 1h and extended for at least 4h after the drug administration.
PMCID: PMC3330835  PMID: 22557254
Radix paeoniae; Antipyretic activity and brewer's yeast-induced pyrexia
13.  Preliminary phytochemical investigation and antibacterial activity of Phyllanthus amarus Schum & Thorn. 
Ancient Science of Life  2007;27(1):1-5.
The aqueous extract of Phyllanthus amarus Schum & Thorn, was selected for preliminary phytochemical and antibacterial activity against human pathogens. Minimum inhibitory concentration was performed by broth dilution method and the zone of inhibition was studied by agar disc diffusion method at concentrations of 10 and 20 mg/ml in DMSO (Dimethyl Sulfoxide). The results revealed the antimicrobial activity of extract against the the strains of microorganisms concentrations in ranges of 60 and 500 μg/ml. Aqueous extract of leaves and roots of Phyllanthus amarus exhibited significant antibacterial activity against eight test bacteria like Staphylococcus aureus, Bacillus subtilis, Staphylococcus albus, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus vulgaris. The plant under study revealed the presence of alkaloids, phytosterols, phenolic compounds and tannins, proteins and amino acids , lignins and saponins.
PMCID: PMC3330836  PMID: 22557251
Antimicrobial activity; Alkaloids; Human pathogen; Phyllanthus amarus; Phytochemical
14.  In vitro antioxidant studies of the ethanolic extract of Tephrosia purpurea L. 
Ancient Science of Life  2007;27(1):26-30.
The ethanolic extract of the root of Tephrosia purpurea was screened for in vitro antioxidant properties using standard procedures. The ethanolic extract exhibited IC50 values of 132.31±8.79 and 405.22±15.09 respectively in DPPH and nitric acid radical inhibition assay. These values were slightly more than those obtained for ascorbic acid and rutin used as standard. The findings justify the therapeutic application of the plant in the indigenous system of medicine, augmenting its therapeutic value.
PMCID: PMC3330837  PMID: 22557256
Tephrosia purpurea; DPPH; Nitric oxide; Free radical scavenging
15.  Exotic flora of some grasslands of Nilgiris with their medicinal uses 
Ancient Science of Life  2007;27(1):38-42.
In addition to the dominance of indigenous plant species, the grasslands of Nilgiris harbour a considerable number of exotic plants with sizeable number of individuals. In the present study in four major grasslands of Nilgiris, out of 12 exotic species present, 10 are recognized as medicinally important. The family, Asteraceae contributed a higher number of 6 medicinal species to the grassland community. The density of exotics in the studied grasslands is varied between 4 and 66/ha. In order to conserve the native species, the frequent harvesting of useful parts of exotics is suggested. In addition cultivation of these exotics in the degraded grasslands and other suitable habitats in Nilgiris may also reduce the pressure upon the native species and at the same time it will also meet the demand.
PMCID: PMC3330838  PMID: 22557258
Exotic medicinal plants; grasslands; Nilgiris
16.  Herbs containing L- Dopa: An update 
Ancient Science of Life  2007;27(1):50-55.
L-Dopa is the drug of choice in the treatment of Parkinson's disease but it has dose related adverse effects such as nausea, vomiting, orthostatic hypotension, end of dose deterioration, on off phenomena and on chronic therapy motor complications synonymous to parkinsonism. Mucuna pruriens (M.P) commonly known as velvet beans or cowitch are used in case of spasms associated with Parkins onism. Clinical efficacy of seeds of this plant was confirmed and the efficacy was contributed to its L-Dopa content. M.P extract showed twice the antiparkinsonism activity compared with synthetic L-Dopa. There is sufficient L-Dopa in broad bean (Vicia faba) pods. One study proved its efficacy in Parkinsonism. Ginkgo biloba extract showed protective effect in vivo and invitro. 50% ethanolic extract of Plumbago zeylanica was effective in rats. The following plants were reported to have L-Dopa but their protective effect is yet to be established in animal models. Vigna aconitifolia, Vigna unguiculata, Vigna vexillata, Prosopis chilensis, Pileostigma malabarica, Phanera vahlis, Parkinsonia acculeata, Macuna urens, Canvavalia glandiata, Cassia floribanda, Casia hirsute and Dalbergia retusa etc.
PMCID: PMC3330839  PMID: 22557260
Antiparkinsonism; L-dopa; alternative medicine; herbs
17.  Anthelmintic activity of root bark of Carissa carandas 
Ancient Science of Life  2007;27(1):11-13.
The anthelmintic activity of the Imethanolic extract of the root bark of Carissa carandas was evaluated on adult Indian earthworm (Pheretima posthuma) using albendazole as a reference standard. The extract caused paralysis followed by the death of worm at the tested dose level. The extract at the highest tested concentration has anthelmintic activity comparable with that of standard drug albendazole.
PMCID: PMC3330840  PMID: 22557253
18.  Hepatoprotective effect of Pterocarpus marsupium against carbon tetrachloride induced damage in albino rats 
Ancient Science of Life  2007;27(1):19-25.
Medicinal plants play a key role in human health care. Pterocarpus marsupium is one of the plants used in treatment of diabetes mellitus and the present study was aimed to assess hepatoprotective effect of the plant against CCl4 induced hepatotoxicity. Wistar albino rats were divided into four groups. Group I was normal control group; Group II, the hepatotoxic group was given CCl4 (2ml/kg body weight intraperitoneally); Groups III received CC14 + Plant extract (100 mg/kg b.w orally); Group IV received only the plant extract. Liver markers were assayed in serum and liver tissue. Levels of marker enzymes such as alanine transminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) and bilirubin were increased significantly in Group II. These enzymes were significantly decreased in Group III treated with plant extracts. The present investigation suggest that the plant had a good protective effect on CCl4 induced hepatic injury.
PMCID: PMC3330841  PMID: 22557255
19.  Phytochemical analysis of Achyranthes aspera and its activity on sesame oil induced lipid peroxidation 
Ancient Science of Life  2007;27(1):6-10.
The effect of Achyranthes aspera on lipid peroxidation were studied in rats fed with Sesame Oil. Increase in the levels of LPO in sesame oil treated groups returned towards normalcy in the plant extract treated groups revealing the antioxidant potential of the plant. Phytochemical studies revealed the presence of secondary metabolites. According to the results obtained Achyranthes aspera inhibited Ferrous Ascorbate stimulated LPO.
PMCID: PMC3330842  PMID: 22557252
Achyranthes aspera; Sesame oil; LPO; Ferrous; Ascorbate; Secondary metabolites
20.  Observations on plantlore in Buldhana District of Maharashtra 
Ancient Science of Life  2007;27(1):43-49.
Traditional medicinal uses for various human diseases of 54 angiospermic species from Shegaon, Sangrampur, Jalgaon (Jamod), Malkapur, Nandura, Motala and Khamgaon tehsils of Buldhana district (Maharashtra) are reported. Of these, applications of 36 species are unknown or little known. The folk medicines consist of a sole drug or a principal drug in combination with other drugs. The recent botanical name, local plant name, recipe, mode of administration, doses etc. are communicated as collected from the tribal and rural folks of the district. It is desirable to screen these species on modern scientific lines.
PMCID: PMC3330843  PMID: 22557259
Ethnomedicine; Buldhana district; Maharashtra
21.  In Vitro Organogenesis of Lycianthes bigeminata Bitter 
Ancient Science of Life  2007;26(4):18-23.
Lycianthes bigeminata Bitter (Solanaceae) is an important medicinal herb distributed in the sholas of Nilgiris and chiefly used for curing ulcer. It is reported that the species is present in the sholas with poor population size in comparison to other constituent species. Owing to the demand and subsequent exploitation, it is predicted that it may occupy still poor association in the sholas of Nilgiris in course of time. Hence in vitro regeneration through employing tissue culture technique is needed. The preliminary attempt in the present study reports that the MS medium supplemented with Benzyl Amino Purine (BAP) and Naphthalene Amino Acid (NAA) at 0.5 mg/l each, induced effective callus formation. However further studies on hardening is suggested to know the survivability of this species.
PMCID: PMC3330881  PMID: 22557245
Lycianthes bigeminata; callus; in vitro organogenesis
22.  Hypolipidemic potential of Panicum miliare on selected cardiovascular subjects 
Ancient Science of Life  2007;26(4):29-32.
Hypolipidemic effect of Samai (.i.e. Panicum miliare) on selected fifty cardiovascular patients were studied for a period of sixty days (25 control; 25 supplemented with Samai). Lipid profiles were analyzed before and after supplementation period for both control and experimental group. It was heartwarming to note that all the lipid values with the exception of HDL – cholesterol had reduced after supplementation with Samai and the reductions were statistically significant at 1 per cent level. There was a mild increase in the HDL cholesterol level, which was desirable.
PMCID: PMC3330882  PMID: 22557247
Prevalence; cardio vascular disease; supplementation; panicum miliare; lipid profile
23.  Phytochemical analysis & Antibacterial activity of Nerium oleander 
Ancient Science of Life  2007;26(4):24-28.
Nerium indicum [Family:Apocynaceae] is commonly known as Arali [Tam] found throughout India, and has been used in the treatment of cancer, cardiotonic, leprosy and skin diseases. Plant parts such as root, bark and leaves are used. The present study is therefore undertaken to analyse its phyto chemical constituents in solvents like Benene, Chloroform and Alcohol and to screen its antibacterial activity. The dried leaf sample is extracted with solvents by cold maceration. The phytochemical analysis showed the presence of Alkaloids, Terpenoids, Cardiac glycosides, Saponins, Tannins & Carbohydrates in all the solvents. All the extracts were screened for antibacterial activity by Disc Diffusion Method. Out of the cultures used Staphylococccus aureus, Pseudomonas aeruginosa and Salmonella typhimurium showed better zone of inhibition which is 10mm, 9mm & 7 mm respectively.
PMCID: PMC3330883  PMID: 22557246
24.  Antibiogram and GC analysis of Euphorbia hirta leaf extract 
Ancient Science of Life  2007;26(4):1-3.
The antibiogram activity of ethanolic and aqueous extract of E.hirta was studied. Ethanol extract of the plant showed the maximal antibacterial activity and G.C Analysis showed the presence of citronellal. The extract showed inhibited the growth of E.coli, S.aureus, P.aeruginosa, Proteus etc.,
PMCID: PMC3330884  PMID: 22557242
Euphorbia hirta; Antibiogram; Gas Chromatography
25.  Studies on Pharmacognostical features of Curcuma domestica Val. 
Ancient Science of Life  2007;26(4):37-41.
The microscopic and macroscopic characters of the rhizome of Curcuma domestica Val. were studied. The behavior of the powdered drug in the presence of various chemicals was also studied. Preliminary phytochemical screening on the various extracts of the rhizome was done in order to ascertain the various chemical constituents present. These studies were carried out to identify this plant for future research work.
PMCID: PMC3330885  PMID: 22557249

Results 1-25 (38)