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1.  Prevalence of Hyperlipidemia in Diabetic Infertile Women 
Ancient Science of Life  2009;29(2):46-48.
The study was carried out to assess the lipid profile levels in diabetic infertile women as diabetes is often associated with infertility. 90 patients in the age limit 20- 40 years. One half diabetic and the other half non-diabetic presenting with a complaint of infertility were evaluated at the G. Kuppusamy Naidu Memorial Hospital, Coimbatore, Tamil Nadu, India. There was a significant increase in the triglycerides and VLDL(Very Low Density Lipid) cholesterol levels in diabetic infertile women when compared to non diabetic infertile women and hence this shows that assessment of Lipo protein levels is of much diagnostic importance and also one among the main criteria for establishing female infertility and diabetes is one of the main contributing factor which may cause fatal disorders like Cardio vascular diseases and Coronary artery diseases due to the vicious cycle caused by the combined vascular abnormalities associated with diabetes.
PMCID: PMC3336305  PMID: 22557351
infertility; triglycerides
2.  Pharmacognostic and Phytochemical analysis of different market samples of Ashoka (Saraca indica Linn) 
Ancient Science of Life  2009;29(2):7-11.
Different market samples of Ashoka (Saraca indica Linn) were analyzed to screen the genuinity of the samples available in the market in the name of Ashoka. All the samples were subjected for Pharmacognostic and Phytochemical analysis and found that all the samples were derived from the different botanical sources.
PMCID: PMC3336306  PMID: 22557344
Ashoka (Saraca indica Linn); Pharmacognostic; Phytochemical
Ancient Science of Life  2009;29(2):1.
PMCID: PMC3336307  PMID: 22557342
4.  Preliminary phytochemical screening of some Indian Medicinal Plants 
Ancient Science of Life  2009;29(2):12-16.
Alkaloids, tannins, saponins, steroid, terpenoid, flavonoids, phenolic compounds and cardie glycoside distribution in five medicinal plants belonging to different families were assessed and compared. The medicinal plants investigated were Asteracantha longifolia (L.) Nees, Psassiflora edulis Sims, Berberis tinctoria Lesch, Sphaeranthus indicus Linn, and Solanum trilobatum Linn. All the plants were found to contain Phenols, Cardiac glycosides, Steroids, Saponins and Tannin except for the absence of flavonoids and Terpenoids in A. longifolia (L.) Nees and Alkaloids in, P edulis Sims, A.longifolia (L.) Nees, B. tinctoria Lesch and S. indicus Linn. respectively. The significance of the plants in traditional medicine and the importance of the distribution of these chemical constituents were discussed with respect to the role of these plants in ethnomedicine in India.
PMCID: PMC3336308  PMID: 22557345
5.  Clinical Study on the Management of Huzaz/Abria (Dandruff) with a pharmacopoeal Preparation of a Unani Medicine and its Cosmetic Evaluation 
Ancient Science of Life  2009;29(2):24-27.
Dandruff called Huzaz/Abria in Unani medicine is a common ailment in the world with easy options of treatment. Most of the treatment options have ignored the cosmetic aspect of hair. Unani medicine has got a vast array of drug formulation to evaluate the efficacy of Unani pharmacopoeal formulation in mild form of seborrhic dermatitis of scalp (dandruff). Its efficacy was compared with standard drug (2% ketakonazole shampoo). Patients were enrolled after ethical clearance and informed consent in the study. 30 patients were treated with Unani formulation and 20 patients with the standard drug. The assessment of various parameters like Itching, Scalp shedding, Erythema, Hair frizz, Hair combing ease, and Hair smoothness was made before and after 30 days. The assessments of the parameters were analyzed and compared using appropriate statistical tests. The study revealed that Unani formulation was equally effective as standard drug and the hair comesis was better than the standard drug as seen clinically, but was not statistically significant (p=0.576).
PMCID: PMC3336309  PMID: 22557347
Dandruff; Hair comesis; Unani Formulation; Hair Frizz; Hair combing ease
6.  Antibacterial activity of methanol extract of Ruta chalapensis (L), Quercus infectoria (Oliver) and Canthium parviflorum (Lam) 
Ancient Science of Life  2009;29(2):28-31.
The present study aimed at evaluating the antibacterial activity of methanol extract of Ruta chalapensis, L., (Rutaceae), Quercus infectoria Oliver., (Fagaceae) and Canthium parviflorum Lam., (Rubiaceae) against Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, Klebsiella oxytocoa, Klebsiella pneumoniae and Proteus mirabilis. The experiment was carried out using disc diffusion method. The results revealed that the methanol extract of aerial parts of Ruta chalepensis (L) presented the highest zone of inhibition against tested pathogens. Other plants showed significant zone of inhibition.
PMCID: PMC3336310  PMID: 22557348
Ruta chalapensis; (L) Quercus infectoria (Oliver); Canthium parviflorum; (Lam) antibacterial activity and zone of inhibition
7.  Pharmacognostical and phytochemical studies on Origanum vulgare L.(Laminaceae) 
Ancient Science of Life  2009;29(2):17-23.
With increasing demand in the field of herbal medicines and cosmetics, it has become necessary and pertinent to probe into the area of systematic knowledge about herbal drugs. There is a need for the application of this knowledge in authentification, detailed study and practical utilization of crude drugs. The present paper deals with the taxonomy, anatomy, powder study pertaining to organoleptic, microscopic, fluorescence, physical constant evaluations and phytochemical screening of Origanum vulgare L.
PMCID: PMC3336311  PMID: 22557346
Origanum vulgare L.; organoleptic; microscopic; fluorescence; physical constant evaluations; phytochemical screening
8.  In vitro antioxidant activities of Asteraceae Plants 
Ancient Science of Life  2009;29(2):3-6.
Anaphalis neelgerriana DC and Cnicus wallichi DC belonging to the family Asteraceae (Compositae) are important medicinal plants indigenous to Nilgiris. Since the related species Anaphalis morrisonicola and Cnicus benedictus were reported for its anti cancer activities, the above mentioned plants were screened for Invitro antioxidant activity. In vitro antioxidant studies were carried out by DPPH, Nitric oxide and Hydrogen peroxide methods for the aerial part extracts of the plants. Different extracts were obtained from the aerial parts of the whole plant by successive solvent extraction and cold maceration process and subjected for Invitro antioxidant activity studies. Among the extracts tested, the ethyl acetate extract of Anaphalis neelgerriana DC and Cnicus wallchi DC showed significant anti oxidant activity in all the above methods. The potent ethyl acetate extract should be tested for anti oxidant activity in animal models.
PMCID: PMC3336312  PMID: 22557343
Anaphalis neelgerriana DC; Cnicus wallchi DC; Invitro studies; Anti oxidant activity
9.  Effect of Snehapana (Internal Oleation ) On Lipids: A Critical Review 
Ancient Science of Life  2009;29(2):32-39.
The Snehana (internal oleation) is a major preparatory procedure to be performed before Śodhana (purification). The entire procedure of Śodhana (purification), depends upon the proper mobilization of humors (Doshas) from the periphery (Śākhā) which is to be achieved with the help of Snehana (Oleation) and Svedana (Sudation therapy). Currently physicians practice purificatory internal oleation (Shodhanartha Abhyantara Snehana) by their methods depending upon individual experience and expertise. If Snehana (internal oleation) is not done properly, it definitely affects the Śodhana Karma (purificatory Therapy) afterwards and also chances of complications such as hyperlipidaemia .Hence, it is obligatory to start and increase the dose of Sneha (lipids) in appropriate & judicious way considering the Digestive fire (Agni) & nature of bowel habit (Koshtha) of the subject. There is a fear in the medical fraternity and the patients that oral intake of lipids may lead to an increase in the biochemical parameters especially the lipids. So in order to remove this misconception, here an attempt is made to critically review in the light of classical references and modern research findings.
PMCID: PMC3336313  PMID: 22557349
10.  Ethno Medical Studies In Kailasagirikona Forest Range Of Chittoor District, Andhra Pradesh 
Ancient Science of Life  2009;29(2):40-45.
The present study reveals the Ethno Botanical studies on uses of medicinal plants in Kailasagiri forest range of Chittoor district, Andhra Pradesh. Role of these studies in rural and forest economies is immense. Tribal people of this area have authentic information on medicinal values of different plant parts like leaves, fruits, flowers, seeds, stem bark, tubers and roots. They have been using these parts in the form of paste, powder, juice, decoction, infusion and also in crude form, with other additives like ghee, sesame oil and goat milk, to relieve from different ailments. The present study brought to the light the immense hidden knowledge of Tribal people towards medicinal plants. Present study discloses the ethnic practices of 52 species belonging to 37 families to relieve different ailments like Skin diseases, Jaundice, Rheumatism, Burning micturation, Fevers, Intestinal worms, Menstrual problems ,Cough, Diarrhea, Head-ache, Cold, Diabetes, Tooth-ache, Asthma, Ear-ache, Eye diseases, Dandruff, Stomach-ache, Insomnia, Indigestion , Piles, Constipation, Cuts, wounds ,Abscesses, Sexual problems, Fractures, Galactagogue, Leprosy and Antidotes, Hair tonics, Abortificients, anti Abortifacients, Lice eradicators and Nasal drops.
PMCID: PMC3336314  PMID: 22557350
11.  Role of medicinal plant Salacia Reticulata in the management of Type II Diabetic Subjects 
Ancient Science of Life  2009;29(1):14-16.
Diabetes mellitus is one of the leading causes of death and ranks third among the chronic diseases. Recent studies have shown that up to 10 % of India's urban population and 2 % of the rural population above the age of 15 years have diabetes and WHO had declared India as the diabetic capital of the world. India has wealth of medicinalplants, and these plants have credited to the development of therapeutic agents for various ailments and diseases. Hark of Salacia Reticulata was screened for its hypoglycemic and hypo-lipidaemic effect. A- total of 60 type II diabetics were enrolled, consisting of experimental group 30 and control group 30. Experimental group received 2 grams of Kadalazhinjil powder daily for a period of 90 days and control group did not receive any supplements. Blood glucose levels before and after medications were estimated in both groups at baseline and at 90 days. There was insignificant reduction in fasting blood glucose, HbA1 c and lipid levels at the end of 90 days in the supplemented group. The experimental group showed encouraging results which call for long term supplementation in Diabetes Mellitus.
PMCID: PMC3336296  PMID: 22557337
Ancient Science of Life  2009;29(1):1-2.
PMCID: PMC3336297  PMID: 22557333
13.  Antibacterial activity on Citrullus colocynthis Leaf extract 
Ancient Science of Life  2009;29(1):12-13.
Studies on the antibacterial activities of the leaf extract of Citrullus colocynthis (Cucurbitaceae), a medicinal plant used for the treatment of various ailments was carried out using agar disc diffusion technique. The results revealed that the crude acetone extract exhibited antibacterial activities against Pseudomonas aeruginosa with zones of inhibition measuring 14.0mm. The chloroform leaf extract exhibited no antibacterial activity against Staphylococcus aureus. The minimum inhibitory concentration for the chloroform extract was 4.0mm for Escherichia coli.
PMCID: PMC3336298  PMID: 22557336
Citrullus colocynthis; agar disc diffusion and antibacterial activity
14.  Diuretic activity of the leaves of Coleus aromaticus Benth 
Ancient Science of Life  2009;29(1):20-21.
The aqueous and ethanolic extract of leaves of Coleus aromaticus was evaluated for diuretic activity. Both extracts were evaluated by determination of urine volume and electrolyte concentration in albino rats. Results revealed that both the aqueous and ethanolic extract at dose 500mgl kg showed significant diuretic activity by increasing the total volume of urine and concentration electrolyte. Furosamide (10 mg/kg) was used as reference drug while normal saline (0.9%) solution was used as control.
PMCID: PMC3336299  PMID: 22557339
Diuretic activity; Coleus aromaticus; Furosamide
15.  Cultivation and Conservation of Guggulu (Commiphora mukul) 
Ancient Science of Life  2009;29(1):22-25.
Guggulu (Commiphora mukul) is about 2-3.5 mt heighted plant of Burceraceae family. The plant grows wild in the arid, rocky tracts, also in low rainy and hot areas. The part used in medicinal preparation is resin, collected by tapping the barks. Guggulu deserves high values in Ayurvedic medicines. Guggulu is Rasayana, Vatakaphaghna, and used in various diseases. Due to high values and excessive demands, improper methods of collection, uncontrolled forest destruction and poor knowledge of cultivation; number of plants highly decreased. Now it categorized as threatened plant. Hence cultivation and conservation of this plant is necessary. Guggulu can be propagated by seed and vegetative method. Germination through seed is very poor. Vegetative propagation through stem cutting is most common and successful method. Farming care is also necessary f or proper growth. Conservation can be effected by knowledge of collection methods and awareness.
PMCID: PMC3336300  PMID: 22557340
Commiphora mukul; tapping; cultivation; Germination; Vegetative propagation; Conservation
16.  Comparative phytochemical analysis of Shorea robusta Gaertn (oleoresin) WSR to its seasonal collection 
Ancient Science of Life  2009;29(1):26-28.
The oleoresin of the Shorea robusta Gaertn is called as Shala niryasa, Kala, Sarja rasa which has the chemical constituents such as nor-triterpene, dammarenolic acid, asiatic acid, dipterocarpol, triterpenic acid, tannic acid and phenolic content and possesses antibacterial, analgesic and wound healing effect.
The medicinal property of the plant is highly influenced by the the season in which it is cultivated and collected. The classical texts of Ayurveda provide guidelines on the time of collection of raw drugs. Hence following these indications the oleoresin was collected in two seasons as per reference of Acharya Charaka and Susrutha in Hemantha rutu (Dec-Jan) and Vasantha rutu (April-May) respectively. Analytical studies revealed that the oleoresin collected in Vasantha rutu contained more tannin, resin, volatile matter, phenolic content, which are the active ingredients of the drug as compared to the oleoresin collected in Hemantha rutu .This is a preclinical work and further clinical study has to be done to prove efficacy of the seasonally collected samples.
PMCID: PMC3336301  PMID: 22557341
17.  In vitro anti-tumour studies on Cnicus wallichi DC 
Ancient Science of Life  2009;29(1):17-19.
Cnicus wallichi DC belonging to the family Asteraceae (Compositae) commonly known as Indian thistle and cirsium wallichi. It is an important medicinal plant indigenous to Nilgiris, Tamilnadu, South India. Since the related species Cnicus benedictus was reported for its anti cancer activities, In vitro screening studies for antitumour activities were carried out for different extracts of Cnicus wallichi DC. Seven different extracts were obtained from the aerial parts of the whole plant by successive solvent extraction and maceration process and subjected for In vitro screening studies. Antitumour study was carried out by short term toxicity studies using Dalton's Lymphoma Ascites (DLA) cells. The ethyl acetate extract of Cnicus wallichi DC showed significant antioxidant activity in all the methods.
PMCID: PMC3336302  PMID: 22557338
Cnicus wallichi DC; In vitro studies; anti tumour activity
18.  Pharmacognostic, Phytochemical and Anti-microbial studies of Solanum indicum leaves 
Ancient Science of Life  2009;29(1):3-5.
The leaves of Solanum indicum showed the presence of stellate trichome. Ethanolic extract of leaves Solanum indicum showed antibacterial activity against Staphylococcus aureus, Bacillus cereus, Escherichia coli where as chloroform extract, acetone extract and ethanol showed anti bacterial against pseudomonas. The aqueous extract did not show any anti microbial activity towards the tested organism. None of the extract showed anti fungal activity.
PMCID: PMC3336303  PMID: 22557334
19.  Pharmacognostical studies on Zanthoxylum armatum leaves 
Ancient Science of Life  2009;29(1):6-11.
The present study deals with the Pharmacognostical investigations on the leaves of Zanthoxylum armatum along with fluorescence characteristics ash and extractive values with an aim to identify and differentiate if from its possible adulterants and / or substitutes.
PMCID: PMC3336304  PMID: 22557335
Zanthoxylum armatum; Pharmacognosy; Fluorescence anlaysis; Powder characteristics
Ancient Science of Life  2009;28(4):1.
PMCID: PMC3336326  PMID: 22557322
21.  In-vitro anti- inflammatory activity of aqueous extract of leaves of Plectranthus amboinicus (Lour.) Spreng 
Ancient Science of Life  2009;28(4):7-9.
Aqueous extract of leaves of Plectranthus amboinicus (lour.) Spreng, which is traditionally used in the treatment of cough and cold was screened for its anti- inflammatory activity by HRBC membrane stabilisation model. Aqueous extract (500 mcg/ml) showed significant anti-inflammatory activity as compared to that of hydrocortisone sodium.
PMCID: PMC3336327  PMID: 22557324
Plectranthus amboinicus (Lour.) Spreng; aqueous extract; anti- inflammatory; HRBC membrane stabilisation
22.  Traditional herbal remedies in Buldhana District (Maharashtra, India) 
Ancient Science of Life  2009;28(4):38-41.
The paper documents traditional herbal remedies from buldhana district of Maharashtra (India). The plant parts most commonly used are bark, leaves, flowers, fruits and seeds, apart from plant products like latex and gum. The medicaments include recipes like decoction, infusion, paste, ash, extract juice, besides gum and latex. There are mainly used afresh. Occasionally, these are supplemented by domestic edible substances of plant-origin. The reliance on herbal medicines for healthcare is associated with traditional belief of effectiveness as well as poor economic status. Role of homestead gardens in native phytotherapy is being focused for the first time from this region. The first-hand information adduced is desired to divulge new lead molecules or will add new sources of herbal medicine.
PMCID: PMC3336328  PMID: 22557332
Traditional herbs; Homestead gardens
23.  Antimicrobial activities of Ichnocarpus frutescens (L.) R.Br. and Hemidesmus indicus R.Br. Roots 
Ancient Science of Life  2009;28(4):13-15.
Hexane, chloroform and aqueous extracts from Hemidesmus indicus and Ichnocarpus frutescens roots were evaluated for their antimicrobial activity. The chloroform extract of both plants showed antibacterial and antifungal activities against the tested organisms. Both the plants showed highest antibacterial and antifungal activity against Eschericia coli and Aspergillus flavus respectively. With increase in concentration of the extract a corresponding increase in diameter of inhibition vgme was observed. The roots of the common substitute of H.Indicus namely Ifrutescenspossess similar antimicrobial properties.
PMCID: PMC3336329  PMID: 22557326
Antibacterial; antifungal; roots; chloroform extract; H.indicus; I.frutescens
24.  Formulation development and in vitro antioxidant studies of Churnas containing natural sweetener and nutraceutical 
Ancient Science of Life  2009;28(4):25-31.
Gymnema sylvestre, Curcuma longa, Azadiracta indica, Aegle marmelos, Salacia chinensis, Emblica officinalis were used as active components and Stevia rebaudiana as natural sweetener with nutraceuticalfor development of Churnas. The free radical scavengingpotential of Churnas was studied by using different antioxidant models of screening. The hydroalcoholic extract of sweet and bitter Churnas at 500μg/ ml showed maximum scavenging of the riboflavin NET system, DPPH and total antioxidant capacity. However, the extract showed only moderate scavenging activity of nitric oxide radicals and iron chelation. This could be due to higher phenolic content in the extract. Sweetness potency of Churna was found to be appropriate sweet, acceptable and palatable. These observations can be useful for the justifications of various ingredients and therapeutic applications of the Churnas.
PMCID: PMC3336330  PMID: 22557329
Churnas; Stevia rebaudiana Antioxidant Potential; Antioxidant in vitro models; Ascorbic acid
25.  Invitro Antioxidant Activity of Selected Antiasthmatic Herbal Constituents 
Ancient Science of Life  2009;28(4):3-6.
Asthmatic patients are more subjected to continuous oxidative stress. Roosting the antioxidant defenses of asthma patient could be beneficial as it may help thwart symptoms of the lung disease and asthma. Considering these facts different plant extracts and phytoconstituents with proven anti asthmatic property had been subjected to antioxidant study at various combinations using Diphenyl Vicryl Hydrazyl radical scavenging method, Hydrogen Peroxide radical scavenging method, Nitric oxide radical inhibition method, ABTS radical scavenging method and Lipid peroxidation assay method.
All the selected herbal based constituents and extracts at different combination showed a potent antioxidant activiy by Nitric oxide radical inhibition activiy method followed by ABTS method. The present finding suggests that the selected plant based anti asthmatic constituents namely Coleus extract (10% Forskolin), Piper longum extract (20% Piperine), CurcuminC3Complex (60% Curcumin), Vasaka (30% Vasicinone), Forskolin (95%), Pperine (98%), Curcumin C3 Complex (98.5%) and Vasicinone (75%) could be utilised in alternate anti asthmatic therapy, since they play a vital role in scavenging Nitric oxide which could prevent the bronchial inflammation in asthmatic patients.
PMCID: PMC3336331  PMID: 22557323
Anti oxidant; Anti asthma; Curcumin; Forskolin; Piperine

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