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1.  In vitro antioxidant activities of Asteraceae Plants 
Ancient Science of Life  2009;29(2):3-6.
Anaphalis neelgerriana DC and Cnicus wallichi DC belonging to the family Asteraceae (Compositae) are important medicinal plants indigenous to Nilgiris. Since the related species Anaphalis morrisonicola and Cnicus benedictus were reported for its anti cancer activities, the above mentioned plants were screened for Invitro antioxidant activity. In vitro antioxidant studies were carried out by DPPH, Nitric oxide and Hydrogen peroxide methods for the aerial part extracts of the plants. Different extracts were obtained from the aerial parts of the whole plant by successive solvent extraction and cold maceration process and subjected for Invitro antioxidant activity studies. Among the extracts tested, the ethyl acetate extract of Anaphalis neelgerriana DC and Cnicus wallchi DC showed significant anti oxidant activity in all the above methods. The potent ethyl acetate extract should be tested for anti oxidant activity in animal models.
PMCID: PMC3336312  PMID: 22557343
Anaphalis neelgerriana DC; Cnicus wallchi DC; Invitro studies; Anti oxidant activity
2.  In vitro anti-tumour studies on Cnicus wallichi DC 
Ancient Science of Life  2009;29(1):17-19.
Cnicus wallichi DC belonging to the family Asteraceae (Compositae) commonly known as Indian thistle and cirsium wallichi. It is an important medicinal plant indigenous to Nilgiris, Tamilnadu, South India. Since the related species Cnicus benedictus was reported for its anti cancer activities, In vitro screening studies for antitumour activities were carried out for different extracts of Cnicus wallichi DC. Seven different extracts were obtained from the aerial parts of the whole plant by successive solvent extraction and maceration process and subjected for In vitro screening studies. Antitumour study was carried out by short term toxicity studies using Dalton's Lymphoma Ascites (DLA) cells. The ethyl acetate extract of Cnicus wallichi DC showed significant antioxidant activity in all the methods.
PMCID: PMC3336302  PMID: 22557338
Cnicus wallichi DC; In vitro studies; anti tumour activity
3.  Invitro Antioxidant Activity of Selected Antiasthmatic Herbal Constituents 
Ancient Science of Life  2009;28(4):3-6.
Asthmatic patients are more subjected to continuous oxidative stress. Roosting the antioxidant defenses of asthma patient could be beneficial as it may help thwart symptoms of the lung disease and asthma. Considering these facts different plant extracts and phytoconstituents with proven anti asthmatic property had been subjected to antioxidant study at various combinations using Diphenyl Vicryl Hydrazyl radical scavenging method, Hydrogen Peroxide radical scavenging method, Nitric oxide radical inhibition method, ABTS radical scavenging method and Lipid peroxidation assay method.
All the selected herbal based constituents and extracts at different combination showed a potent antioxidant activiy by Nitric oxide radical inhibition activiy method followed by ABTS method. The present finding suggests that the selected plant based anti asthmatic constituents namely Coleus extract (10% Forskolin), Piper longum extract (20% Piperine), CurcuminC3Complex (60% Curcumin), Vasaka (30% Vasicinone), Forskolin (95%), Pperine (98%), Curcumin C3 Complex (98.5%) and Vasicinone (75%) could be utilised in alternate anti asthmatic therapy, since they play a vital role in scavenging Nitric oxide which could prevent the bronchial inflammation in asthmatic patients.
PMCID: PMC3336331  PMID: 22557323
Anti oxidant; Anti asthma; Curcumin; Forskolin; Piperine
4.  A comparative pharmacognostical evaluation of two Artemisia species found in Nilgiris biosphere 
Ancient Science of Life  2007;27(2):7-13.
Artemisia pallens Wall. ex DC commonly known as “Davana” in Kannada and Artemisia abrotanum Linn. known as “Southernwood” (Asteraceae) are aromatic herbs, erect in habit, upto 60 cm tall, leaves are very small, much divided, bluish green. These plants find use in traditional systems of medicine viz., anthelmintic, tonic and antipyretic properties. Since, these species have not been scientifically evaluated; the present study was aimed to bring these plants under a suitable pharmacognostical scheme.
PMCID: PMC3330844  PMID: 22557262
5.  Pharmacological validation of Kantha chendooram for antiulcer activity in modified pylorus ligated (shay) rat model 
Ancient Science of Life  2007;27(2):38-43.
The use of metals and minerals is predominant in siddha system of medicine. As per siddha concept, peptic ulcer is known as Valigunmam, the basic abnormality appears to be the derangement of metabolism in the stomach and duodenum resulting in malfunctioning of the secretory process of gastric mucosa. Chendooram is a group of siddha drugs which is used for anemia, obesity, rheumatic diseases; abdominal tumours etc.During the present study standardized Kantha chendooram was selected and evaluated for its anti-ulcer activity, which could not be attempted by researchers earlier.
PMCID: PMC3330850  PMID: 22557268
Siddha drug Kantha Chendooram Anti-ulcer activity
6.  STANDARDIZATION OF KANTHA CHENDOORAM 
Ancient Science of Life  2006;26(1-2):89-91.
Siddha is a traditional medical system of India. According to siddha system of medicine, chendooram is a red colour powder generally made of metallic compounds. Mercury is used in the form of rasa chendooram (red oxide of mercury). This paper deals with the standardization of Kantha chendooram. It is a Siddha preparation of 8 ingredients, viz. 1. Purified Lode Stone, 2. Purified Sulphur, 3. Lead wort root powder, 4. Eclipta juice, 5. Lime juice, 6. Milk, 7. Egg albumin, 8. Madar Latex. In this study an attempt was made to standardize Kantha chendooram which has not been attempted by researchers earlier. Standardization of Kantha chendooram was in terms of its organoleptic characters, qualitative identification of phytochemical constituents, metallic quantification and in terms of pharmacognostical standardization.
PMCID: PMC3335228  PMID: 22557232
7.  ANTIFUNGAL ACTIVITY OF SOME COLEUS SPECIES GROWING IN NILGIRIS 
Ancient Science of Life  2006;26(1-2):82-84.
The in vitro antifungal activity of solvent extracts of Coleus forskohlii, Coleus blumei and Coleus barbatus were compared by testing against some pathogenic fungi like Aspergillus niger, Aspergillus fumigatus, Aspergillus ruantii, Proteus vulgaris and Candida albicans. The petroleum ether extract of Coleus forskohlii and Coleus barbatus exhibited significant antifungal activity against all the selected organisms. The extracts of Coleus blumei did not show any significant antifungal activity against the selected organisms.
PMCID: PMC3335232  PMID: 22557230
8.  PHARMACOGNOSTICAL STUDIES OF ON Cnicus wallichi DC LEAF 
Ancient Science of Life  2006;25(3-4):19-22.
Cnicus wallichi DC belonging to the family Asteraceae, was studied to fix the parameters for pharmacognostical standards in order to ensure the use of only genuine and uniform materials of such herbal remedies, work on standardization assumes vital significance. Pharmacognostical study has therefore, been carried out, covering detailed morphological and anatomical characters, features of the powdered drug including leaf constants like Vein islet number, Vein termination number, Stomatal number, Stomatal index, Palisade ratio, Powder microscopy of the leaf and stem. Physical constants like ash values and extractive values.
PMCID: PMC3335211  PMID: 22557202
9.  PHARMACOLOGICAL VALIDATION OF Musa paradisiaca BHASMA FOR ANTIULCER ACTIVITY IN ALBINO RATS – A PRELIMINARY STUDY 
Ancient Science of Life  2006;25(3-4):67-70.
Siddha system of medicine is one of the ancient systems of medicine in India. According to Siddhars, peptic ulcer is known as Valigunmam with its signs and symptoms as detailed in Siddha literature matching modern terminology of peptic ulcer. Bhasma refers to calcinated metals and minerals. During this study the Bhasma of Musa paradisiaca Linn, is prepared and evaluated for its antiulcer effect in albino wistar rats which could not be attempted by researchers earlier.
PMCID: PMC3335216  PMID: 22557209
10.  ANTI INFLAMMATORY ACTIVITY OF CONE VOLA TILE OIL OF CUPRESSUS FUNEBRIS Endl 
Ancient Science of Life  2005;25(1):1-3.
The volatile oil obtained from the cones of Cupressus funebris by hydrodistillation was subjected to anti-inflammatory activity using carrageenan induced paw oedema model using albino mice, Diclofenac sodium was used as standard drug (25 mg/kg body weight, p.o.). The volatile oil (100 mg/kg body weight, p.o.) showed significant anti inflammatory activity.
PMCID: PMC3330895  PMID: 22557180
Cupressus funebris; Volatile oil; Anti-inflammatory activity; Carrageenan; Diclofenac
11.  Evaluation of Anti –Inflammatory Activity of Eclipta alba in rats 
Ancient Science of Life  2005;24(3):112-118.
The anti-inflammatory effect of the plant of Eclipta alba (Family – Asteraceae) was evaluated using carrageenin, mediators such as histamine and serotonin induced paw oedema, and cotton pellet induced granuloma tests for their effect on acute and chronic phase inflammation models in rats. Maximum inhibition (55.85%) was noted at the dose of 500 mg/kg after 3 hr of drug treatment in carrageenin induced paw oedema, whereas the Indomethacin (standard drug ) produced 61.30% of inhibition. In the chronic model (cotton pellet induced granuloma) the CEEA and standard drug showed decreased formation of granuloma tissue by 49.7,41.5,22.1% and 53.48 % respectively. The results indicate the potent anti-inflammatory effect and therapeutic efficacy of Eclipta alba extract on animal models, which is compared with Indomethacin.
PMCID: PMC3330935  PMID: 22557164
Eclipta alba; anti-inflammatory effect; cotton pellet-induced granuloma
12.  Antioxidant potential of Lactuca sativa 
Ancient Science of Life  2004;24(1):6-10.
The present study is based on the evaluation of antioxidant potential of a well known plant Lactuca sativa. Methanolic leaf extract was investigated for in vitro inhibition of oxidative damage induced by UV-radiations to the salmonella typhi bacteria and in vivo effect on the production of body enzymes i.e. catalase and superoxide dismutase. The lipid peroxidation masurement was also done in terms of thiobarbituric acid reactive substances (TBARS) in blood and brain of male albino wistar rats. The plant extract has shown significant antioxidant potential both in vitro and in vivo.
PMCID: PMC3330910  PMID: 22557144
13.  ANTIBACTERIAL STUDIES ON LEAF EXTRACT OF ELEPHANTOPUS SCABER Linn 
Ancient Science of Life  2004;23(3):6-8.
Methanolic extract of Elephantopus scaber Linn was investigated for its antibacterial activity against Staphylococcus aureus (NCIM – 2079), Escherichia coli (NCIM-2067), Bacillus subtilis (NCIM-2063), Pseudomonas aeruginosa (NCIM-2036), Proteus vulgaris (NCIM-2027) at 100 μg/disc by using disc diffusion method. The extract showed significant anti bacterial activity and were compared to chloramphenicol (30 μg/disc).
PMCID: PMC3330967  PMID: 22557125
14.  SOME LESS KNOWN CENTRAL NERVOUS SYSTEM DEPRESSANT 
Ancient Science of Life  2003;23(1):35-39.
The present communication reports some medicinal plants which are used as Central Nervous System sedative agent in the traditional system of medicine.
PMCID: PMC3330954  PMID: 22557110
15.  PHARMACOGNOSTICAL STUDIES ON LEAVES OF ATAIANTIA MONOPHYIA CORREA 
Ancient Science of Life  2003;22(4):129-133.
Leaves of Atalantia monophylla are used in chronic rheumatism and paralysis. The Pharmacognostical studies like histological characters, leaf constants, ash values and extractive values of leaves of Atalantia monophylla Corr were carried out. The preliminary phytochemical analysis were also carried out.
PMCID: PMC3331017  PMID: 22557099
16.  COMPARATIVE MICROBIOLOGICAL ACTIVITIES OF ETHANOLIC EXTRACTS OF ROOTS AND AERIAL PARTS OF ACHYRANTHES ASPERA LINN 
Ancient Science of Life  2003;22(4):140-145.
Ethanolic extract of roots and aerial parts of Achyranthes aspera was investigated for its antibacterial activity against Bacillus subtilis, Bacillus pumilus, and Proteus vulgaris and anti fungal activity against Cryptococcus neoformans, Aspergillus flavus at 100 mg/disc using diffusion method. The comparative studies shown that ethanolic extract of roots and aerial parts of Achyranthes aspera have exhibited moderately equal action when compared to Cotrimoxazole (30 mg/disc) for antibacterial and Clotrimazole (30 mg/disc) for antifungal activity. Our findings confirm the traditional therapeutic claims for this herb.
PMCID: PMC3331019  PMID: 22557101
17.  PURGATIVE AND ANTI-INFLAMMATORY ACTIVITIES OF CASSIA DIDYMOBOTRYA, FRESEN 
Ancient Science of Life  2002;22(1):9-12.
Aqueous and ethanol extracts of cassia didymobotraya were investigated for purgative and anit-inflammatory activities in albino mice and rats, respectively at a dose of 100 mg/kg body weight. Anti-inflammatory activity was screened by 1% carageenan induced paw edema method and purgative activity was screened by the method described by Akah etal, Both the extracts exhibited significant purgative and anti-inflammatory activities, which are comparable to standard drugs, Senna (20mg/kg) and indomethacin (20mg/kg). Ethanol extract showed higher purgative and anti-inflammatory than aqueous extract. The percentage of protection of aqueous, ethanol extracts and indomethacin were found to be 35.29,37.25 and 43.13.
PMCID: PMC3330987  PMID: 22557069
18.  ANTIMICROBIAL ACTIVITY OF SELECTED HERBAL EXTRACTS 
Ancient Science of Life  2002;21(3):188-190.
Methanolic extract of oleoresins of Araucaria bidwilli Hook: and aerial parts of Cytisus scoparius Linn. Were screened for antimicrobial activity against two bacterial strains-Bacillus subtilis (Gram Positive) and Escherichia coli (Gem negative), and two fungal strains – Candida albicans and crytococcus neoformans by two-fold serial dilution technique. The results showed that all the microorganisms used were sensitive to the extracts. The minimum inhibitory concentrations (MIC) for A. bidwilli were found to be 31.25 μg/ml for Bacillus subtilis and 500 μg/ml for all other organisms used in the study. In case of C. Scoparius, the MIC values were 250 μg/ml for B. Subtilis and 500 μg/ml for allthe other strains used. However, in comparison the ampicillin (MIC: 62.5 μg/ml), and Amphotericin-B (MIC: 125 μg/ml ), the activities of both the extracts were less except A. bidwilli against B.Subtilis.
PMCID: PMC3331033  PMID: 22557052
19.  ANTI-INFLAMMATORY ACTIVITY OF DODONAEA VISCOSE 
Ancient Science of Life  1998;18(2):152-156.
Dodonaea viscose, Linn is a widely grown plant of Nilgiris district of Tamil and is commonly used by the tribals of Nilgiris as a traditional medicine for done fracture and joint sprains. Since it is generally believed tat fractures are accompanied by either some degree of injury or inflammations, it was felt desirable to carry our anti inflammatory activity of Dodonaea viscose. Anti-inflammatory activity of the plant was carried out by carrageenin induced paw edema method in Wister albino rats.
PMCID: PMC3331069  PMID: 22556883
20.  PRELIMINAR PYTOCHEMICAL STUDY ON LEAVES AND STEMS OF BRACHYLEPIS NERVOSA WIGHT & ARNOT 
Ancient Science of Life  1998;18(2):112-119.
Brachylepis nervosa, Wight and Arnot, belongs to the family asclepiadaceae is indigenous to ills of the Nilgiris and distribution of which is restricted to Wellington and kothagiri. The present work summarises preliminary phytochemical characters of this plant.
PMCID: PMC3331075  PMID: 22556877
21.  ANTI – TUMOUR EFFECT OF BERBERIS ASIATICA ROXB. EX. DC. ON DALTON'S LYMPHOMA ASCITE 
Ancient Science of Life  1998;17(4):290-299.
Berberis asiatica Roxb. Ex. Dc., non Griff. Belongs to the family berberidaceae commonly occurring in the dry outer Himalaya, Assam etc. Roots along with stem bark s a reputed drug in Ayurvedic medicine contain several alkaloids. 50% Ethaolnic extract of roots reported to posses anti-cancer activity. The present study examines the antitumour effect of ethanolic root extract (BRE) against Dalton's lymphoma ascites tumour cells and solid tumour in swiss albino mice, A significant enhancement of mean survival time of BRE treated tumour bearing mice was found. Oral administration of BRE reduced the solid tumour induced by DLE and restored the altered haematological parameters to normal.
PMCID: PMC3331127  PMID: 22556858
22.  CYTOTOXIC AND ANTI –TUMOUR PROPERTIES OF ETHANOLIC EXTRACT OF BACOPA MONNIERI (L) PENN 
Ancient Science of Life  1998;17(3):228-234.
Bacopa Monnieri (L) penn. Belongs to the family scrophulariaceae is commonly used in Ayurvedic system of medicine to treat various disease. The present stud examines the anti-tumous effect of ethanolic extract of whole plant bacopa monnieri (L) (EEMB) by in vitro short term chemosensitivity and in vivo tumous model test systems. EEBM dose dependently inhibited the proliferation of transformed cell lines significantly. Fifty percent dose on 3 hour exposure to EEBM was 150 μg/ml for Dalton's lymphoma ascites tumour cells (Dla). Oral administration of the EEBM retarded the development of solid tumour and restored the altered hematological parameters near to normal.
PMCID: PMC3331112  PMID: 22556847
23.  SANTOLINA VOLATILE OIL, A POTENTIAL ANTIFEEDANT FOR THE CONTROL OF THE BROWN PLANT HOPPER, MILAPARVATHA LUGENS 
Ancient Science of Life  1996;15(3):166-168.
The essential oil of santolina chamaecyparissus reduced the survival of Nilaparvatha lugens after 72 hours. The oil is found to be a good pesticide.
PMCID: PMC3331208  PMID: 22556739
24.  AN IN VITRO STUDY ON THE ANTIMICROBIAL EFFECT OF SELECT HETEROCYCLIC NITROGEN COMPOUNDS 
Ancient Science of Life  1995;15(2):137-139.
In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2-substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3-(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicrobial activity was measured using standard two -fold serial dilution method and the minimum inhibitory concentration (MIC) values are determined, The MIC of pyrazoles and pyrido[1,2 -a] pyrimidines are found to be 25 μg/ml to 50 μg/ml against E. Coli and 50 μg/ml against B.subtilis respectively. Both pyrazole and pyrido [1,2-a] Pyrimidines are found to be totally ineffective against C. albicans.
PMCID: PMC3331202  PMID: 22556732
25.  ANTI-PYRETIC ACTIVITY OF SOME PLANTS IN FEMALE ALBINO RATS: A PRELIMINARY REPORT 
Ancient Science of Life  1995;14(4):253-257.
Ethanolic extracts of Ailanthus exceisa (AE). Toddalia asiatica (TA) and Araucaria bidwilli (AB) were screened by the anti-pyretic activity in yeast induced hyperthermic test model in the laboratory. Dose of AE (100), TA (60) and AB (30) mg., equivalent of the plant material per kg. Body weight of the extracts were administered orally to the female albino rats. Acute toxicity and preliminary phytochemical screening were conducted for all the extracts. LD 50 values on oral administration of the extracts were found to be AE (1000), AB (350) and TA (250) mg. per kg. body weight respectively. Both the root and aerial part fractions of TA displayed a pronounced anti-pyretic activity comparable to the standard drug paracetamol. AB oleoresin fraction was also found to show anti-pyretic effect. These observations however, confirm the folk-medical practices still prevailing among the tribes.
PMCID: PMC3331248  PMID: 22556707

Results 1-25 (28)