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1.  Hypoglycaemic activity of Embelia ribes berries (50% etoh) extract in alloxan induced diabetic rats 
Ancient Science of Life  2008;27(4):41-44.
Oral administration of Embelia ribes berries (50% EtoH) reduced blood sugar level significantly. In intact rats, blood sugar levels were decreased by 13.1% and 20.3% after 3 hrs. and 5 hrs. of treatment respectively. While in alloxan induced diabetic rats blood glucose levels were decreased after 3 hours and 5hours by 28.1% and 34.5% respectively. Hypoglycaemic action of Embelia ribes berries may be due to its direct action on tissue or due to increase in insulin secretion.
PMCID: PMC3330868  PMID: 22557285
Blood Sugar; Alloxan; Hypoglycaemic; Diabetic
2.  Contraceptive efficacy of Plumbago zeylanica root extract (50% etoh) in male albino rats with special emphasis on testicular cell population dynamics 
Ancient Science of Life  2008;27(3):31-35.
The administration of Plumbago zeylanica root (50% EtOH) extract to |intact rats at the dose of 150 mg/kg [body weight for 60 days caused arrest of spermatogenesis. The diameter of seminiferous tubules and Leydig cell nuclei were reduced. The production of spermatocytes (primary and secondary) and spermatids were significantly reduced (P£ 0.001; 83.57%, 89.69% and 69.47% respectively). The total number of immature and mature Leydig cells was significantly decreased (P£ 0.001; 68.62% and 71.14%), where as degenerating cells were significantly increased (58.26%). Decreased testicular cell population reflects contraceptive or antispermatogenic nature of Plumbago zeylanica extract and may be of vital use in fertility control.
PMCID: PMC3330854  PMID: 22557275
3.  EFFECT OF HYPERLIPIDAEMIA ON REPRODUCTIVE ORGANS IN MALE ALBINO RABBITS : A HISTOLOGICAL APPROACH 
Ancient Science of Life  2004;23(4):16-19.
The present study was aimed to study the effects of hyperlipidaemia on the histology of various reproductive organs. The chronic oral administration of cholesterol diet (400 mg/kg bodyweight/day for 60 day) induced hyperlipidaemia in male rabbits. It showed severe degeneration in germinal epithelium. Few spermatocytes could be seen, but the number was decreased. The seminiferous tubules were wavy and shrunken. As the tubule had large number of primary spermatocytes, it seems that the meiotic divisions were inhibited. Leydig cells nuclei were shrunken and the distribution of Leydig cells was abnormal. The histoarchitecture of cauda epididymis showed lesser number of spermatozoa in lumen and shrinkage was observed in epithelial cell line.
PMCID: PMC3330981  PMID: 22557136
Hyperlipidaemia; Seminiferous tubules; Leydig cells; Spermatogenesis
4.  ANTIFERTILITY EFFECT OF LINDENBERGIA INDICA (70% EtOH) EXTRACT 
Ancient Science of Life  2003;22(3):111-114.
Oral feeding of 70% EtOH extract of Lindenbergia indica to female rats at the dose of 500 mg/kg body weight and 1000 mg / kg body weight caused significant reduction of serum cholesterol, HDL – cholesterol, triglycerides & phospholipids (P≤ 0.05 to P≤ 0.001). Where as the protein levels were not reduced significantly.
Fertility test showed 100% negative results. The negative fertility reflects the arrest of Oogenesis & depletion of estrogen level. Further Lindenbergia indica reflects antiestrogenic nature.
PMCID: PMC3331010  PMID: 22557096
5.  Antifertility Efficacy of Neem Bark (Azadirachta indica A.juss.) in Male Rats 
Ancient Science of Life  1999;19(1-2):21-24.
Subcutaneous treatment of 50% EtOH extract of neem bark (Azadirachta indica A. juss) to male rats at the dose of 10 mg for 30 days caused arrest of spermatogenesis. The diameter of serminiferous tubule, Leydig cell nucleus and epithelial heights of epididymides were significantly reduced (p≤0.001). Sperm motility and density were significantly reduced. Reduced testicular and accessory organ protein, sialic acid and vesicular fructose content manifested arrest of spermatogenesis and depletion of androgen level.
PMCID: PMC3336455  PMID: 22556912
6.  ANTIFERTILITY EFFICACY OF CURCUMA LONGA (50% E to H EXTRACT) WITH SPECIAL REFERANCE TO SERUM BIOCHEMISTRY and FERTILITY TEST 
Ancient Science of Life  1999;18(3-4):192-194.
Oral feeding of 50% EtOH extract of Curcuma longa to male rats at the dose of 1gm/kg body weight caused significant reduction of serum cholesterol, triglycerides and phospholipids (P≤0.01 to 0.001). Whereas the SGOT levels aware not reduced significantly. Fertility test showed 80% negative result. The negative fertility results reflects the arrest of spermatogenesis and depletion of androgen level. Further Curcuma longa reflects antispermatogenic nature.
PMCID: PMC3336478  PMID: 22556889
Moringa oliefera leaves; Odema suppression; Carrageenan
7.  CONTRACEPTIVE EFFICACY OF SOLANUM XANTHOCARPUM BERRY IN MALE RATS 
Ancient Science of Life  1992;12(1-2):264-266.
Oral feeding of 50% EtOH of Solanum xanthocarpum berry to male rats at the dose of 0.5 gm/kg body weight caused arrest of spermotagenesis. The number of spermatocytes (primary and secondary) and spermatids were significantly reduced (P<0.05 to 0.001). The total number of immature and mature leydig cells were significantly decreased (P<0.001), whereas degenerating cells were significantly increased (P<0.001). The decreased testicular cell population reflects antispermatogenic nature of Solanium xanthocarpum berry extract.
PMCID: PMC3336623  PMID: 22556599
8.  HYPOGLYCEMIC EFFECT OR NEEM BARK AND FLOWER ON STREPTOZOTOCIN – INDUCED DIABETES IN MICE 
Ancient Science of Life  1991;11(1-2):28-30.
Three to six hours after the administration of extracts of neem bark or flower, the blood glucose levels of normal and streptozotocin-induced diabetic mice dropped significantly. However, neem flower possesses stronger hypoglycemic activity than the bark. Hypoglycemic action of these extracts may be due to their metabolic effect on tissue and or due to increase in insulin secretion.
PMCID: PMC3336580  PMID: 22556555

Results 1-8 (8)