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1.  Inhibition of in vitro cytotoxic effect evoked by Alpinia galanga and Alpinia officinarum on PC - 3 cell line 
Ancient Science of Life  2008;27(4):33-40.
Plants have been a source of medicine and a major resource for health care since ancient times, with some traditional herbal medicines having been in use for more than 2,000 years. Herbs and spices are recommended for prevention and cure of various diseases including cancer. Alpinia galanga and Alpinia officinarum, botanical cousin to ginger was recognized superior in many ways and has been employed in medicine for over a thousand years. Prostate cancer is the most common form of cancer in males and the second leading cause of cancer related death. PC-3 cell line was derived from adenocarcinoma of human prostate. This was assayed for MTT assay on treatment with ethanolic extract of Alpinia galanga and Alpinia officinarum, where in inhibition of the cell growth was noticed. This study was supported by DNA fragmentation where a characteristic DNA laddering was noticed in treated tumor cell line and not in the control.
PMCID: PMC3330871  PMID: 22557284
Cytotoxicity; MTT assay; Alpinia galanga; Alpinia officinarum; DNA fragmentation
2.  In vitro Antioxidant and Antilipidperoxidative potential of Pleurotus florida 
Ancient Science of Life  2007;26(4):11-17.
The ethanolic extract of Pleurotus florida was studied for its free radical scavenging property on different in vitro models like 1,1 -diphenyl-picryl hydrazyl (DPPH)Assay, Ferric Reducing Antioxidant Power (FRAP) assay and in vitro antilipidperoxidative assay using goat liver homogenate and RBC Ghost model. The in vitro Lipid peroxidation (LPO) was inhibited to a good extent by the Pleurotus florida ethanolic extract and the extent of inhibition being higher in the RBC membrane model than the liver homogenate model. The mushroom extract showed good dose-dependent free radical scavenging property in both the models.
PMCID: PMC3330889  PMID: 22557244
free radical scavenging; Pleurotus florida; Antioxidant
3.  ANTIBACTERIAL EFFICACY AND PHYTOCHEMICAL OBSERVATION OF SOME INDIAN MEDICINAL PLANTS 
Ancient Science of Life  2007;26(3):16-22.
The aim of the study is to evaluate the antibacterial activity of Pistacia integerrima, Cedrus deodara and Gymnema sylvestre against seven different microorganisms such as Escherichia coli, Salmonella typhi, Klebsiella pneumoniae, Proteus vulgaris, Pseudomonas, Bacillus subtillis and Staphylococcus aureus by using disc diffusion method. Preliminary studies with ethanol extract and water extract of plants indicated that the growth of test organism was markedly inhibited by ethanol extract of Pistacia integerrima and Gymnema sylvestre. But in case of Cedrus deodara, water extract was more effective. Efficacy of plant extract which showed variable inhibitory activity against each bacteria was compared to standard antibiotic (tetracyclin). The two extracts were subjected to qualitative analysis to find out phytoconstituents present . Results showed that Pistacia integerrima contained all the phytochemicals, so exhibited higher antibacterial activity.
PMCID: PMC3330876  PMID: 22557236
Anti bacterial activity; Pistacia integerrima; Cedrus deodara; Gymnema sylvestre; phytochemical activity
4.  INHIBITION OF IN VITRO LIPID PEROXIDATION (LPO) EVOKED BY CALOCYBE INDICA (MILKY MUSHROOM) 
Ancient Science of Life  2006;26(1-2):42-45.
The present study was designed with an objective to assess the inhibition of lipid peroxidation (LPO) by the aqueous extract of Calocybe indica (milky mushroom) using an invitro model of goat liver homogenate and RBC ghosts. The invitro LPO was inhibited to a good extent by the aqueous extract of milky mushroom and the extent of inhibition being higher in the RBC membrane model when compared with liver homogenate model.
PMCID: PMC3335235  PMID: 22557223
Calocybe indica; LPO
5.  HYPOCHOLESTEROLAEMIC EFFECT OF SPIRULINA AND LIV-52 IN LEAD INDUCED TOXICITY IN ALBINO RATS 
Ancient Science of Life  2004;24(2):73-78.
Effect of spirulina and Liv-52 on lead induced hypercholesteroleamia in albino rats was studied. Oral administration of lead acetate(10mg/kg body weight/day) for 30 days resulted in a significant increase(P<0.01) in the level of serum total cholesterol, triglycerides, LDL Cholesterol and a significant decreases in the level of serum HDL cholesterol, when compared to normal and control group of albino rats. Administration of either Liv-52 alone or in combination with spirulina produced a well pronounced protective effect against lead induced hypercholesteroleamia in rats. Although administration of spirulina alone caused an appreciable protective effect in lead toxicated tats, further study is needed with increased doses to evaluate its optimal effect.
PMCID: PMC3330924  PMID: 22557156

Results 1-5 (5)