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1.  Antitumour Activity of Poochendurappattai in Albino Rats in Albino Rats 
Ancient Science of Life  2000;20(1-2):82-84.
The water extract of poochendurappattai was screened for antitumour activity at the doss of 5mg, 10mg, 20mg and 50 mg/kg body weight in rats against methylcholanthrene induced fibrosarcoma. There was 63% regression in the tumour weight at the doses of 10mg and 20 mg/kg body weight. This antitumour activity may be due to compounds like royaleanones since royaleanones are known to possess anticancer activity. Te phytochemical investigation of poochendurappattai revealed the presence of royaleanones.
PMCID: PMC3336418  PMID: 22557002
2.  ANTI – INFLAMMATORY POTENTIAL OF BALARISHTA AND DHANVANTARA GUTIKA IN ALBINO RATS 
Ancient Science of Life  1998;17(4):305-312.
Balarishta and Dhanvantara gutika are ayurvedic medicines prescribed in different diseases including rheumatism. These medicines were screened for anti-inflammatory activity against cotton pellet induced granuloma in albino rats. There was significant reduction in cotton pellet weight by both the tested drugs. Dhanvantara gutika significantly reduced the ascorbic acid in adrenal. Acid phosphatase, GPT and GOT activities were significantly reduced by Balarishta, Dhanvantara gutika and phenyl butazone in liver. In the serum acid phosphatase activity was significantly reduced by both the tested drugs and phenul butazone while GPT activity was lowered by Balarishta alone and GOT activity was reduced by Balarishta and Dhanvantara gutika. Phenyl butazgone reduced the activity of GPT.
PMCID: PMC3331117  PMID: 22556860
3.  ON THE ANTIBACTERIAL ACTIVITY OF SOME SIDDHA MEDICINES 
Ancient Science of Life  1998;17(3):194-202.
Talaka mattirai, Iti vallati meluku, tamibira parpam and Naka centuram of siddha system of medicine were screened for antibacterial activity against S. aureus, S.citreus, S.faecalis B. Subtilis, P.aeruginosa, Coli, S.Boydii, V.cholerae and Klebsiella sp. Talaka matrirai ibihibited the growth of s. faecalis, V.cholerae and B. Subtilis at a concentration of 0.6 mg/ml and 1mg/ml respectively. P.aeruginosa growth was inhibited at a concentration of 0.2mg/ml V. cholerae. at a concentration of 0.6mg/ml and S.boydii at a concentration of 1mg.l by iti vallati meluku. Tambira parpam inhibited the growth of S. faecalis and S. boydii at a concentration of 0.2mg/ml, V.cholerae at a concentration of 0.6mg/ml and S citreus and B. subtilis at a condensation of 1mg/ml there was inhibition of growth of S. citreus and B. subtilis by naka centuram at a concentration of 1mg/ml. Manometric studies revealed the total inhibition of S.boydii by Tambira parpam at a concentration of 1mg/ml while at 0.6mg/ml concentration inhibition was similar to tat of chlroamphenicol (1mg/ml). The antibacterial activity of these medicines was due to ingredients involved in these preparations.
PMCID: PMC3331113  PMID: 22556841
4.  HEPATOPROTECTIVE ACTIVITY OF NAVAYASA CURNA AND HASAVA COMBINATION 
Ancient Science of Life  1997;16(4):332-336.
Navayasa curna mixed in Lohasava was screened for hepatoprotective activity against carbon tetrachloride induced liver injury in albino rats at a dose of 100mg/kg body weight. The drug reduced liver weight, alkaline phosphatase and GOT activity in liver and chloresterol and GPT activity in serum. There was no effect on protein and liver glycogen.
PMCID: PMC3331172  PMID: 22556808
5.  STANDARDISATION OF KARPURASAVA 
Ancient Science of Life  1994;14(1-2):49-52.
Asavas and aristhas are medicines prepared by fermentation. In some medicines alcohol produced by fermentation is distilled and added to the powdered drugs for a fixed period, filtered and the filtrate is used as medicines.
Karpurasava is prepared by distilling the alcohol. The quantity of alcohol in the distillate was 9.87% by the textual method while it was 5.77% by glass distillation apparatus. The alcohol content in Karpurasava was 8.7%.
PMCID: PMC3336496  PMID: 22556675
6.  ANTI-INFLAMMATORY ACTIVIY OF PREMNA TOMENTOSA WILLD. IN ALBINO RATS 
Ancient Science of Life  1993;13(1-2):185-188.
An alcoholic extract of the leaves of Premna tomentosa Willd at a dose of 100 mg/kg body weight exhibited significant anti-inflammatory activity in albino rats. The extract caused reduction in the weight of spleen, thymus and adrenals. It reduced cotton pellet granuloma by 32.21%. The serum biochemical parameters showed reduction in protein, acid phosphatase and transaminases. The activity of P. tomentosa was comparable to phenylbutazone.
PMCID: PMC3336536  PMID: 22556646
7.  STUDIES ON THE STANDARDISATION OF CURNAS PART – II TALIZADYA CURNA 
Ancient Science of Life  1991;11(1-2):46-49.
Talisadya churna was prepared by pounding the individual ingredients in mortar and pestle and mixie. The Curna prepared by pounding the ingredients in mortar and pestle showed higher exhaustive extraction in hexane and solubility in alcohol. The Curna prepared by grinding the ingredients in mixie showed less acid insoluble content, high volatile matter, water soluble matter, and exhaustive extraction in chloroform. Thin layer silica gel chromatography and test of organic functional groups did not show any difference in the Tulisadya curna prepared by either method.
PMCID: PMC3336572  PMID: 22556560
8.  STUDIES ON COMMERCIAL SAFFRON 
Ancient Science of Life  1991;10(3):187-190.
Two commercial samples of saffron were analysed for moisture and ash contents, solubility in water, action with sulphuric acid, presence of foreign dyes and colour intensity of water soluble solution.
The moisture content in Laccha was 12.7% while it was 11% in Mogra. The ash was 4.7% in both the samples. The water soluble matter in Laccha was 52.7% and 45.8% in Mogra. There was no foreign dye in these samples. The colour intensity of 0.02% saffron solution of both the samples corresponded to 0.07% of potassium dichromate at 470 mm.
PMCID: PMC3331286  PMID: 22556531
9.  STUDIES ON MRTASANJIVANI SURA 
Ancient Science of Life  1989;8(3-4):220-222.
Mrtasanjivani sura was prepared according to the formulary in an earthen pot and in a glass vessel. The drug fermented in glass vessel was distilled using glass joint distillation apparatus and that fermented in earthen pot was distilled by baka yantra method. The alcohol content in the finished medicine in the glass distilled and baka yantra methods were 3.44% and 4.70% respectively. The medicine of each container was acidic in nature.
PMCID: PMC3336719  PMID: 22557653
10.  PREPARATION OF “777 OIL” USED FOR PSORIASIS IN SIDDHA MEDICINE BY MODIFIED METHOD 
Ancient Science of Life  1988;8(1):17-19.
“777 oil” a coded drug of Siddha system of medicine was prepared and analyzed in the paper. The drug showed 3.62, 13.57 and 266.9 Iodine value, acid number and saponification number respectively. The bark which was one of the ingredients in the drug was possessing 0.63% nitrogen in the acid soluble portion. The bark also exhibited proeolytic activity and the optimum pH was 4.
PMCID: PMC3331347  PMID: 22557623
11.  COMPARATIVE AND FERMENTATION STANARDISATIOND STUDIES ON DASAMULARISHTA 
Ancient Science of Life  1988;8(1):68-70.
Asavas and arishtas are produced by fermentation in an earthen pot according to textual procedure. The size and shape of the pot and the quantity of the drug. That can be taken in a pot for fermentation is not mentioned in the literature. The present Study was taken up to determine the quantity of drug that can be fermented in an earthen Pot to obtain best results.
Dasamularishta was fermented in different volumes in earthen pots of identical size, shape and capacity, as well as in stainless steel vessel and porcelain jar.
The drug filled up to 3/4th of the volume of the earthen pot had shown better results than the earthen pots containing various volumes of drug. The stainless steel container and porcelain jar also showed comparable results to the earthen pot fermented drug. Thin layer chromatography of different preparation showed five spots.
PMCID: PMC3331353  PMID: 22557633
12.  PROCESS AND PRODUCT STANDARDISATION OF “77 OIL” USED FOR PSORIASIS IN SIDDHA MEDICINE 
Ancient Science of Life  1986;6(1):35-41.
“777 oil” is a code drug of the Siddha system of medicine used in the treatment of Psoriasis. The drug is derived from the leaves Wrightia tinctoria by insolation, with coconut oil as base. The present study is aimed at comparing the drug prepared by insolation with that prepared in darkness.
Analytical studies carried out in both the drugs showed difference in acid number without exposing to sunlight. The drugs showed changes in acid and iodine numbers on exposure to sunlight.
Studies on Thin Layer Chromatography showed no difference between the two drugs. However semi quantitative chromatography showed that two spots were more in concentration in the drug prepared in darkness than the drug processes in sunlight. Except one spot all the spots Rf values are identical to raw coconut oil.
In analytical studies carried out in shade dried leaves of Wrightia tinctoria showed the presence of iron calcium and ammonium. Alcohol had maximum extractive matter.
PMCID: PMC3331391  PMID: 22557546
13.  EXPERIMENTAL STUDIES ON THE FERMENTATION OF ARAVINDASAVA 
Ancient Science of Life  1986;5(4):243-246.
Aravindasava was prepared as per the textual and modified methods. The modified methods involved the use of glass vessel and inoculation of the autoclaved drug with the yeasts isolated from Dasamularista and Pippaliasava.
The quantity of alcohol produced in the glass vessel was more than that in the earthen pot by classical method. Among the inoculated organisms, Dasamularista yeast II showed highest alcohol production. There was difference in the degree of utilization of reducing and non – reducing sugars by the growing microorganisms in the fermenting vessel in different method of preparation.
PMCID: PMC3331475  PMID: 22557532
14.  EFFECT OF INSOLATION ON ‘777 OIL’ USED FOR PSORIASIS IN SIDDHA SYSTEM OF MEDICINE 
Ancient Science of Life  1985;5(1):17-20.
“777 oil” is a coded drug of the Siddha system of medicine prescribed in Psoriasis. Sunlight plays an important role in the preparation of the drug as well as in the treatment of the cases.
In vitro studies carried out with the drug exposed to sunlight for four hours showed an increase in acid and iodine values. The visible spectrum was changed in shape at the wave length 480 to 580 mm. The thin layer chromtographs employing different solvent systems did not show any difference. The drug resolved in to two to three spots in these solvents and did not indicate any response of the drug to insulation.
PMCID: PMC3331435  PMID: 22557493
15.  CHEMICAL, MICROBIOLOGICAL AND COMPARATIVE FERMENTATION STUDIES ON DASAMULARISHTA 
Ancient Science of Life  1984;4(2):123-126.
Dasamularista was prepared as per the national formulary to study the effect of container on the production of alcohol and the presence of microorganisms during the process of fermentation. Citraka (Plumbago rosea Linn.) which was one of the ingredient in the drug and subjected to “Sodhana” was also studied. The Citraka was impoverished by 50% with respect to plumbagin as a result of sodhana-purification. The drug prepared in glass vessel showed higher amount of alcohol than the earthen pot product. During the process of fermentation two yeasts and one bacteria, Micrococcus luteus wee observed in the media, the bacterium being a non-alcohol producing organism.
PMCID: PMC3331500  PMID: 22557464
16.  EFFECT OF TIME ON THE FERMENTATION AND STORAGE OF CANDANASAVA 
Ancient Science of Life  1984;4(1):51-55.
Asavas and aristas are produced by fermentation. The usual fermenting period as per the texts is one month. But the Ayurvedic practitioners believe that prolonged incubation results in increased alcohol content of the products. Candanasava was prepared and studied to examine whether these claims are tenable. Maximum alcohol production (9.8%) in 30 days was reached in the earthen pot. With the progress of time beyond 30 days there was loss of yield, alcohol and sugar. There was rich growth of fungi in the pots.
Candanasava stored in glass bottles did not show any change in any of the measured parameters. There was no increase of alcohol with the prolonged storage contrary to the claims. Chromatographically there was no difference between candanasava as obtained after 30 days fermentation period in earthen pot and the same product stored in glass bottles for three more months
PMCID: PMC3331484  PMID: 22557449

Results 1-16 (16)