PMCC PMCC

Search tips
Search criteria

Advanced
Results 1-1 (1)
 

Clipboard (0)
None
Journals
Authors
Year of Publication
Document Types
jtitle_s:("Age (dodr)")
1.  Aging-related characteristics of growth hormone receptor/binding protein gene-disrupted mice 
Age  2006;28(2):191-200.
Since generation of the growth hormone receptor/binding protein (GHR/BP) gene-disrupted mouse nearly 10 years ago, use of this mouse model has become widespread in the elucidation of the physiological roles of GH and insulin-like growth factor-1 (IGF-1). In particular, it serves as a useful model to study mechanisms of aging. This review highlights the evidence demonstrating that the loss of GH signaling leads to lifespan extension in mice, and presents the multiple characteristics of this mouse line that suggest the life extension is due to alteration of the aging process.
doi:10.1007/s11357-006-9004-x
PMCID: PMC2464722  PMID: 19943140
aging; gene disruption; growth hormone receptor/binding protein; longevity; mice

Results 1-1 (1)