PMCC PMCC

Search tips
Search criteria

Advanced
Results 1-2 (2)
 

Clipboard (0)
None
Journals
Authors
Year of Publication
Document Types
jtitle_s:("Age (dodr)")
1.  Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study 
Age  2006;28(4):363-374.
Age trajectories of physiological indices contain important information about aging-related changes in the human organism and therefore may help us understand human longevity. The goal of this study is to investigate whether shapes of such trajectories earlier in life affect the residual life span distribution. We used longitudinal limited access data from seven physiological indices and life spans of respective individuals collected in the Framingham Heart Study (FHS). These include: diastolic blood pressure (DBP), pulse pressure (PP), body mass index (BMI), serum cholesterol (SCH), blood glucose (BG), hematocrit (HC), and pulse rate (PR). We developed a method for assigning individuals to groups of potentially long-lived (PLL) and potentially medium-lived (PML) groups using age trajectories of physiological indices at the age interval between 40 and 60 years. The analysis shows that the longevity of individuals who survived to age of 65 depends on the behavior of the physiological indices between 40 and 60 years of age.
doi:10.1007/s11357-006-9023-7
PMCID: PMC1994150  PMID: 17895962
Age trajectories; Aging; Exceptional longevity; Longitudinal data; Physiological indices; The Framingham Heart Study
2.  Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study 
Age (Dordrecht, Netherlands)  2006;28(4):363-374.
Age trajectories of physiological indices contain important information about aging-related changes in the human organism and therefore may help us understand human longevity. The goal of this study is to investigate whether shapes of such trajectories earlier in life affect the residual life span distribution. We used longitudinal limited access data from seven physiological indices and life spans of respective individuals collected in the Framingham Heart Study (FHS). These include: diastolic blood pressure (DBP), pulse pressure (PP), body mass index (BMI), serum cholesterol (SCH), blood glucose (BG), hematocrit (HC), and pulse rate (PR). We developed a method for assigning individuals to groups of potentially long-lived (PLL) and potentially medium-lived (PML) groups using age trajectories of physiological indices at the age interval between 40 and 60 years. The analysis shows that the longevity of individuals who survived to age of 65 depends on the behavior of the physiological indices between 40 and 60 years of age.
doi:10.1007/s11357-006-9023-7
PMCID: PMC1994150  PMID: 17895962
age trajectories; aging; exceptional longevity; longitudinal data; physiological indices; the Framingham Heart Study; BG blood glucose; BMI body mass index; CVD cardiovascular disease; DBP diastolic blood pressure; FHS the Framingham Heart Study; HC hematocrit; LL long-lived; ML medium-lived; PLL potentially long-lived; PML potentially medium-lived; PP pulse pressure; PR pulse rate; SCH serum cholesterol; SL short-lived

Results 1-2 (2)