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1.  The Antiplasmodial Agents of the Stem Bark of Entandrophragma Angolense (Meliaceae) 
In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane - methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7α-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC50s of 2 and 5.4 µg/ml respectively. Other compounds were moderately active.
PMCID: PMC2816453  PMID: 20162084
Plasmodium falciparum; Meliaceae; Entandrophragma angolense; Limonoids; Fatty acids; Triterpenoids; 7α-obacunyl acetate; 24-methylenecycloartenol; anti-plasmodial activity
2.  Antimalarial Activity in Crude Extracts of Some Cameroonian Medicinal Plants 
Fifteen crude extracts from the stem bark and seeds of four medicinal plants, viz: Entandrophragma angolense, Picralima nitida, Schumanniophyton magnificum and Thomandersia hensii were tested in vitro for their antimalarial activity against the chloroquine-resistant Plasmodium falciparum W2 strain. The results showed that the extracts of these plants possessed some antimalarial activity, the methanol extract of Picralima nitida demonstrating the highest activity in vitro. Further isolation and identification of some active compounds from these plants will justify their common use in traditional medicine for the treatment of malaria or fever in Cameroon.
PMCID: PMC2816424  PMID: 20162079
Entandrophragma angolense; Picralima nitida; Schumanniophyton magnificum; Thomandersia hensii; Plasmodium falciparum; Antimalarial activity
3.  Effects of the Aqueous and Hexane Extracts of Mondia Whitei on the Sexual Behaviour and Some Fertility Parameters of Sexually Inexperienced Male Rats 
The effects of Mondia whitei Hook (Skeels) were studied on the sexual behaviour and some fertility parameters of sexually inexperienced male rats. Animals were orally administered 100 mg/kg and 500 mg/kg of body weight (b.w) of either the aqueous or the hexane extracts of Mondia whitei whilst the control group received 10 mL/kg b.w of 0.3% Tween 80 once/day for 14 days. Their sexual behaviour was monitored on days 0, 1, 7 and 14 days of treatment and 14 days post-treatment. Some fertility parameters (index libido, quantal pregnancy, fertility index) of the treated rat were evaluated on day 13 of treatment by pairing it overnight with two proestrus females. Results showed that Mondia whitei extracts significantly (p<0.001) reduced the mount latency and the hexane extract was found to be more efficient than the aqueous extract. The treatment had no significant effect (p>0.05) on intromission, ejaculation and erection. The fertility of the animals remained unaffected. It's concluded that Mondia whitei had sexual enhancement of the sexually inexperienced male rats.
PMCID: PMC2816420  PMID: 20162070
Mondia whitei; sexual behaviour; inexperienced male rat

Results 1-3 (3)