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1.  Novel roles of the picornaviral 3D polymerase in viral pathogenesis 
Advances in virology  2010;2010:368068.
The RNA-dependent RNA-polymerase, 3Dpol, is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of 3Dpol in mice has antiviral effects. Here we discuss the structure and function of 3Dpol during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in 3Dpol after picornavirus infection, highlight data showing the antiviral effects of transgenic 3Dpol from Theiler’s murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which 3Dpol is causing this antiviral effect in mice.
doi:10.1155/2010/368068
PMCID: PMC2897181  PMID: 20625447
2.  Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis 
Advances in Virology  2010;2010:368068.
The RNA-dependent RNA-polymerase, 3Dpol, is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of 3Dpol in mice has antiviral effects. Here, we discuss the structure and function of 3Dpol during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in 3Dpol after picornavirus infection, highlight data showing the antiviral effects of transgenic 3Dpol from Theiler's murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which 3Dpol is causing this antiviral effect in mice.
doi:10.1155/2010/368068
PMCID: PMC2897181  PMID: 20625447

Results 1-2 (2)