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1.  Effects of metal-on-metal wear on the host immune system and infection in hip arthroplasty 
Acta Orthopaedica  2010;81(5):526-534.
Background and purpose
Joint replacement with metal-on-metal (MOM) bearings have gained popularity in the last decades in young and active patients. However, the possible effects of MOM wear debris and its corrosion products are still the subject of debate. Alongside the potential disadvantages such as toxicity, the influences of metal particles and metal ions on infection risk are unclear.
Methods
We reviewed the available literature on the influence of degradation products of MOM bearings in total hip arthroplasties on infection risk.
Results
Wear products were found to influence the risk of infection by hampering the immune system, by inhibiting or accelerating bacterial growth, and by a possible antibiotic resistance and heavy metal co-selection mechanism.
Interpretation
Whether or not the combined effects of MOM wear products make MOM bearings less or more prone to infection requires investigation in the near future.
doi:10.3109/17453674.2010.519169
PMCID: PMC3214739  PMID: 20860450

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