The title compound, C21H22N2O, crystallizes with two independent molecules in the asymmetric unit. In both molecules, the anthracene ring systems are almost planar, with maximum deviations of 0.071 (8) and 0.028 (7) Å, and make dihedral angles of 73.4 (2) and 73.3 (2)° with the least-squares planes formed by the four C atoms of the morpholine rings, which adopt a chair conformation. An intramolecular C—H⋯π interaction occurs. In the crystal, the packing is stabilized by weak C—H⋯O hydrogen bonds, which connect pairs of molecules into parallel to the c axis, and C—H⋯π interactions.
crystal structure; C—H⋯π interactions; Schiff bases; anthracene; morpholine; methanimine
In the title compound, C13H18N2O3, the benzene ring makes a dihedral angle of 17.19 (11)° with the least-squares plane formed by the four C atoms of the morpholine ring, which adopts a chair conformation. In the crystal, C—H⋯N hydrogen bonds link the molecules into supramolecular chains running along a 21 screw axis parallel to the b-axis direction. Weak C—H⋯π interactions are also observed.
crystal structure; hydrogen bonding; C—H⋯π interactions; Schiff bases; morpholin-4-amine
In the title compound, C19H25N5O2, the morpholine ring has a chair conformation. The plane of the central benzene ring makes dihedral angles of 88.75 (12) and 60.02 (7)°, respectively, with the mean plane formed by the four planar C atoms of the morpholine ring and with the plane of the triazole ring. In the crystal, molecules are linked via C—H⋯π interactions, forming slabs lying parallel to (10-1). The C atoms of the bridging ethylene group, between the morpholine and benzene rings, and the terminal ethene group of the prop-1-ene substituent attached to the triazole ring, are disordered over two sets of sites, with an occupancy ratio of 0.634 (13):0.366 (13).
crystal structure; Schiff base; morpholine; 1,2,3-triazole; disorder
In the title compound, C15H15ClN2O5S, the tetrahydrofuran ring adopts an envelope conformation with the O atom as the flap. The pyrrolidine ring adopts an envelope conformation with the chlorine-substituted C atom as the flap. In the crystal, two types of C—H⋯O hydrogen bonds generate R
2(20) and R
4(26) rings, with adjacent rings running parallel to ac plane. Further C—H⋯O hydrogen bonds form a C(6) chain, linking the molecules in the b-axis direction.
The title compound, C16H23N3O3, contains two morpholine rings, each of which adopts a chair conformation. The molecular conformation is stabilized by an intramolecular O—H⋯N hydrogen bond, leading to a S(6) ring. In the crystal, molecules are linked into zigzag chains along the c-axis direction by C—H⋯O and C—H⋯π interactions.
In the title compound, C20H18N4O3, the dihedral angles between the central benzene ring and the 1H-1,2,3-triazole ring and the fused benzene ring are 65.34 (19) and 3.64 (18)°, respectively. The dioxole ring adopts a shallow envelope conformation, with the methylene C atom displaced by 0.156 (5) Å from the other four atoms (r.m.s. deviation = 0.007Å). In the crystal, the molecules are linked by C—H⋯O and C—H⋯N hydrogen bonds, generating a three-dimensional network.
In the title compound, C14H13ClN2O5S, the chlorine-substituted tetrahydrofuran ring adopts a twist conformation and the other tetrahydrofuran ring an envelope conformation with the O atom as the flap. The pyrrolidine ring adopts a twist conformation. In the crystal, C—H⋯O hydrogen bonds link the molecules into zigzag chains running along the b-axis direction.
The title compound, C23H24FN3O, crystallizes with two independent molecules (I and II) in the asymmetric unit. These pairs of molecules are linked to each other as N—H⋯O dimers with an R
2(10) motif. Furthermore, the crystal structure also exhibits C—H⋯π interactions. The atoms of the ethyl group in molecule I are disordered over two sites with an occupancy ratio of 0.817 (6):0.183 (6).
In the title compound, C24H24FN3O2S, the 1,3-thiazolidine ring adopts an envelope conformation with the S atom as the flap, while the cyclohexane ring is in a chair conformation. In the crystal, molecules are linked by N—H⋯O and C—H⋯F hydrogen bonds, forming a three-dimensional network. The unit cell contains six voids of 57 Å3, but the residual electron density (highest peak = 0.23 e Å−3 and deepest hole = −0.19 e Å−3) in the difference Fourier map suggests no solvent molecule occupies this void.
In the title compound, C24H26FN3O, the cyclohexane ring adopts a chair conformation; the propyl substituent is in an equatorial orientation and the bond-angle sum at the C atom bonded to the carbohydrazide N atom is 360.0°. The dihedral angle between the 1H-indole ring system and the phenyl ring is 82.77 (13)°. A weak intramolecular C—H⋯π contact occurs. In the crystal, pairs of molecules related by a crystallographic twofold axis are linked by bifurcated N—H⋯(O,N) hydrogen bonds; a C—H⋯O interaction occurs between the same pair. The dimers are linked by C—H⋯F and C—H⋯π interactions, generating a three-dimensional network.
The title compound, C22H22FN3O, crystallized with two independent molecules (A and B) in the asymmetric unit; these are linked by a pair of N—H⋯O hydrogen bonds, forming a pseudo-centrosymmetric dimer with an R
2(10) motif. In addition, a number of C—H⋯π interactions are also observed. The 1H-indole ring systems in molecules A and B are essentially planar [maximum deviations of 0.019 (2) and 0.014 (2) Å, respectively] and make dihedral angles of 77.64 (10) and 69.50 (9)°, respectively, with thephenyl rings.
In the title compound, C16H18ClN3O, the cyclohexane ring adopts a distorted chair conformation. In the crystal, pairs of molecules are linked by N—H⋯O hydrogen bonds into inversion dimers, forming R
2(10) ring motifs. These dimers are connected through C—H⋯N hydrogen bonds into chains along the a axis, forming layers parallel to (101).
In the title compound, C19H12Cl2N2O4, the imine bond length of 1.257 (6) Å is typical of a double bond. The dihedral angle between the para-nitro benzene ring and the central benzene ring is 12.06 (3)° and that between the central benzene and the para-chloro benzene ring is 73.81 (2)°. An intramolecular O—H⋯N hydrogen bond generates an S(6) ring motif. In the crystal, molecules are linked together by two pairs of C—H⋯O interactions (to the same O atom acceptor), forming inversion dimers. A short Cl⋯Cl contact [3.232 (4) Å] is observed.
The title compound, C18H11BrF3NO2, crystallizes in the phenol–imine tautomeric form, with a strong intramolecular O—H⋯N hydrogen bond. The dihedral angle between the naphthalene ring system and the benzene ring is 28.54 (10)°.
The title compound, C19H14F3NO2, crystallizes in the keto–amine tautomeric form, with a strong intramolecular N—H⋯O hydrogen bond. The molecule is almost planar; the dihedral angle between the naphthalene ring system and the benzene ring is 4.60 (7)°. In the crystal, molecules are linked into chains along the c axis by C—H⋯O hydrogen bonds. The F atoms of the trifluoromethyl group are disordered over two positions with refined site occupancies of 0.668 (9) and 0.332 (9).
In the title compound, C18H15N5O2S, a weak intramolecular C—H⋯S hydrogen bond results in a small dihedral angle of 3.71 (9)° between the methylphenyl and triazole rings, which, in turn, form dihedral angles of 80.09 (8) and 77.32 (8)°, respectively, with the benzoxazolone mean plane. In the crystal, N—H⋯O hydrogen bonds link molecules into chains along , and weak C—H⋯N hydrogen bonds and π–π interactions between the five- and six-membered rings [centroid–centroid distances = 3.5074 (11) and 3.616 (1) Å] consolidate the crystal packing.
In the title compound, C20H23NO, the cycloheptanone ring adopts a twist-chair conformation, with the aminomethyl substituent in an equatorial position. The relative configuration of the two stereocenters is R,R. In the crystal, molecules are linked by N—H⋯O hydrogen bonds into chains along .
In the title compound, C25H17ClF3N3O2S, the five-membered 1,3-thiazolidine ring adopts a twist conformation. The three F atoms of the CF3 group are disordered over two sets of sites with refined occupancies of 0.542 (18) and 0.458 (18). In the nine-membered 1H-indoline ring system, the 1H-pyrrole ring forms a dihedral angle of 4.7 (2)° with the benzene ring, while it is twisted at an angle of 46.5 (2)° with respect to the attached phenyl ring. The dihedral angle between the phenyl and trifluoromethyl-substituted benzene rings is 56.0 (2)°. In the crystal, N—H⋯O hydrogen bonds connect the molecules into a three-dimensional network. In addition, weak C—H⋯O hydrogen bonds and weak C—H⋯π interactions are observed.
In the title compound, C19H20N2O3, the cyclohexanone ring adopts a chair conformation with the aminomethyl group is positioned equatorially. An intramolecular N—H⋯O hydrogen bond occurs. In the crystal, molecules are linked by N—H⋯O hydrogen bonds.
The title compound, C24H27N2Si+·Br−·H2O, was synthesized from 1-(dimethylphenylsilylmethyl)-1H-benzimidazole and (2-bromoethyl)benzene in dimethylformamide. The benzimidazole ring system is nearly planar, with a maximum deviation of 0.015 (5) Å, and forms dihedral angles of 73.0 (3) and 39.6 (2)°, with the phenyl rings. In the crystal, molecules are linked by O—H⋯Br, C—H⋯Br and C—H⋯O hydrogen bonds. In addition, the structure features π–π stacking interactions, with a face-to-face separation of 3.644 (3) Å between parallel benzimidazole ring systems.
In the title compound, C29H27ClN4O2, the six-membered ring of the pyridazine group is nearly planar [maximum deviation = −0.062 (2) Å] and its mean plane makes dihedral angles of 43.05 (9), 44.71 (10) and 72.57 (9)°, respectively, with the two phenyl and benzene rings. The piperazine ring has a chair conformation and its mean plane is almost perpendicular to the attached benzene ring, with a dihedral angle of 83.20 (16)°. In the crystal, molecules are linked via two pairs of C—H⋯O interactions, which result in the formation of chains propagating along [10-1]. Neighbouring chains are linked via C—H⋯π interactions.
In the title compound, C21H22N4O3, the triazole ring is planar [maximum deviaton = 0.004 (1) Å] and makes dihedral angles of 26.21 (8) and 38.66 (8)° with the two benzene rings. In the crystal, molecules are linked by C—H⋯O hydrogen bonds, forming zigzag chains along [1-11]. In addition, a weak C—H⋯π intreraction is also observed.
In the title molecule, C18H16N2O3, the five-membered ring has an envelope conformation, with the substituted C atom deviating by 0.342 (4) Å from the mean plane P calculated for the remainder of the non-H atoms of the 2,3-dihydro-1H-indene fragment. The mean planes of quinazoline-2,4(1H,3H)-dione fragment and P form a dihedral angle of 59.08 (4)°. In the crystal, pairs of N—H⋯O hydrogen bonds link molecules into inversion dimers, and weak C—H⋯O hydrogen bonds and π–π interactions between the benzene rings of the quinazoline ring systems [centroid–centroid distance = 3.538 (3) Å] further consolidate the packing.
In the title Schiff base compound, C13H9Cl2NO, the molecule displays an E conformation about the imine C=N double bond, with a dihedral angle of 8.09 (11)° between the two benzene rings. In the crystal, molecules are linked by a single O—H⋯O hydrogen bond, giving one-dimensional chains which extend along (100).
In the title compound, C14H11ClN2O2, the 2,3-dihydro-1,3-benzoxazole ring system is essentially planar [maximum deviation = 0.009 (2) Å] and makes a dihedral angle of 79.15 (7)° with the phenyl ring. Intermolecular N—H⋯O and weak C—H⋯Cl hydrogen bonds occur in the crystal structure.