Two independent mol­ecules, A and B, comprise the asymmetric unit of the title compound, C21H18N2OS, with the difference in the angle of orientation between the naphthalene ring system and the mean plane of the cyclo­heptyl ring [16.13 (1) in A and 11.48 (5)° in B], being evident. The cyclo­heptyl ring adopts a distorted chair conformation in each mol­ecule with r.m.s. deviations of 0.2345 (4) (A) and 0.2302 (4) Å (B). Intra­molecular O—H⋯N hydrogen bonding generates planar six-membered S(6) loops with r.m.s. deviations of 0.0099 (1) (A) and 0.0286 (1) Å (B).

In the title compound, C19H17NO4S, the phenyl ring and the naphthalene ring system are oriented at a dihedral angle of 4.12 (2)° and the mol­ecule adopts a U-shaped conformation. The Cc—C—N—S (c = carb­oxy) torsion angle is 90.98 (15)°. In the crystal, mol­ecules are linked by O—H⋯O and N—H⋯O hydrogen bonds, resulting in (100) chains incorporating centrosymmetric R 2 2(14) and R 2 2(10) loops. Weak aromatic π–π stacking is also observed [centroid–centroid separations = 3.963 (2) and 3.932 (2) Å].

The title compound, C18H22N2O5S, is largely planar, with an r.m.s. deviation of 0.0546 (1) Å of atoms from the mean plane through all non-H atoms except for the methyl groups. The benzene and pyrimidine­dione rings are inclined to one another at a dihedral angle of 1.41 (7)°. In the crystal, weak C—H⋯O inter­actions connect the mol­ecules into chains propagating along the b-axis direction.

In the title complex, [PtCl2(C6H16N2)], the PtII atom adopts a distorted cis-PtN2Cl2 square-planar coordination geometry. The five-membered chelate ring adopts a twisted conformation. In the crystal, weak C—H⋯Cl hydrogen bonds link the mol­ecules into (001) sheets.

The mol­ecule of the title compound, C11H13ClN2O2, is approximately planar (r.m.s. deviation = 0.099 Å for non-H atoms) and adopts a Z conformation about the C=N double bond. In the crystal, mol­ecules are linked by N—H⋯O and C—H⋯O hydrogen bonds to the same O-atom acceptor, forming zigzag chains propagating along [010]. These inter­actions give rise to R 2 1(6) loops.

In the title compound, [Fe(C5H5)(C8H11N4S)], the cyclo­penta­dienyl (Cp) rings of the ferrocene unit are close to being eclipsed. They are inclined to one another at an angle of 1.95 (2)° and lie 3.309 (2)Å away from each other. The ethyl­idene­thio­carbonohydrazide fragment is planar, with an r.m.s. deviation of 0.0347 (2) Å from the mean plane of its eight non-H atoms, and makes dihedral angles of 21.78 (1) and 19.97 (1)° with respect to the two Cp rings. The mol­ecule adopts a trans geometry about the C=N double bond. In the crystal, N—H⋯(N/S) and C—H⋯S inter­actions stack the mol­ecules in an inverse fashion along the b axis.

The mol­ecule of the title compound, C11H13ClN2O3, is planar (r.m.s. deviation = 0.0587 Å for non-H atoms) and adopts a Z conformation about the C=N double bond. In the crystal, mol­ecules are linked via an N—H⋯O hydrogen bond, forming zigzag chains propagating along [010]. These chains are consolidated by C—H⋯O hydrogen bonds.

In the title compound, C15H13N3O2, the dihedral angle between the benzotriazole ring system (r.m.s. deviation = 0.0124 Å) and the benzene ring is 76.21 (3)°. The meth­oxy C atom deviates from its benzene ring plane by 0.063 (2)Å. In the crystal, inversion dimers linked by pairs of C—H⋯O hydrogen bonds generate R 2 2(12) loops.

In the title compound C8H6BrN3O, the benzotriazole ring is essentially planar (r.m.s. deviation = 0.0034 Å) and the bromo­acetyl unit is twisted at a dihedral angle of 15.24 (16)° with respect to it. In the crystal, pairs of C—H⋯O hydrogen bondings result in the formation of inversion dimers, forming R 2 2(12) rings, which are connected by further C—H⋯O inter­actions into chains extending along the b-axis direction.

In the title compound, C14H21NO4S, the O—S—O angle is 120.06 (11)°, with the S atom adopting a distorted tetra­hedral geometry. In the crystal, N—H⋯O hydrogen bonds connect the mol­ecules along the a axis, generating an infinite chain. The disordered C atoms of the isobutyl group were refined with the C—C distances restrained to 1.52 (1) Å and the occupancy ratio refined to 0.504 (3):0.496 (3).

In the crystal structure of the title compound, C11H15NO4S, two independent mol­ecules are present per asymmetric unit; they are dimerized through O—H⋯O hydrogen bonds between their carb­oxy groups to generate R 2 2(8) loops. An intra­molecular N—H⋯O link in one of the mol­ecules closes an S(5) ring. The dimers are linked by N—H⋯O and C—H⋯O hydrogen bonds to form a three-dimensional network. The C atoms of the isopropyl group of one of the mol­ecules are disordered over two orientations in a 3:1 ratio.

In the title compound, C12H16N2O6S, the S atom adopts a distorted tetra­hedral geometry with an O—S—O angle of 119.76 (13)°. The nitro group is twisted by 35.34 (2)° with respect to the aromatic ring; it accepts an N—H⋯O hydrogen bond, resulting in a S(7) motif. In the crystal, N—H⋯O and O—H⋯O hydrogen bonds connect the mol­ecules into an infinite chain along the a axis. The methyl C atoms of the isopropyl group are disordered in a 1:1 ratio.

In the title compound, C17H17BrN2O, the N-containing ring adopts an envelope conformation with the C atom carrying the phenyl ring displaced by −0.531 (9) Å from the plane defined by the remaining five atoms (r.m.s. deviation = 0.0099 Å). The benzene ring is almost orthogonal to the ring to which it is attached, the CCN—C—CPh—CPh torsion angle being −101.3 (7)°. The cyclo­hexene ring is disordered over two conformations in a statistical ratio. The most prominent inter­actions in the crystal are pairs of N—H⋯O hydrogen bonds between inversion-related mol­ecules. The resulting dimers are linked into a three-dimensional architecture by C—H⋯N, C—H⋯Br and C—H⋯π inter­actions.

In the title compound, C20H18O2, the fused-ring systems are essentially planar (r.m.s. deviations of the nine fitted atoms = 0.009 and 0.027 Å) and exhibit an orthogonal relationship [dihedral angle = 79.83 (5)°]. To a first approximation, the ketone-O atoms are directed to opposite sides of the mol­ecule. A three-dimensional architecture arises in the crystal packing owing to C—H⋯O, C—H⋯π and π–π inter­actions [between centrosymmetrically related benzene rings with centroid–centroid distance = 3.7647 (10) Å].

In the title compound, C14H11ClN2O2, two independent mol­ecules (A and B) comprise the asymmetric unit with the main difference between them being the relative orientation of the pendent phenyl ring with respect to the fused-ring system [dihedral angles = 8.32 (8)° (A) and 28.32 (8)° (B)]. In the crystal, the A mol­ecules are connected into a linear supra­molecular chain along the a axis via C—H⋯O inter­actions and linked to this via C—H⋯Cl inter­actions are the B mol­ecules. The chains are connected into layers in the ab plane by π–π inter­actions between pyrazole (A) and pyran (B) rings, and between pyrazole (B) and pyran (A) rings [centroid–centroid distances = 3.5442 (11) and 3.4022 (10) Å, respectively].

In the title compound ethanol monosolvate, C23H21N3O2S·C2H5OH, the dihydro­pyrazole ring is twisted about the Csp 3—Csp 3 bond. Nevertheless, the ring approximates a plane (r.m.s. deviation for the fitted atoms = 0.132 Å) and forms dihedral angles of 5.80 (13) and 12.29 (12)°, respectively, with the fused- and sulfonamide-benzene rings. As the dihydro­pyrazole C-bound phenyl group is roughly perpendicular to the dihydro­pyrazole ring [dihedral angle = 74.04 (15)°; the amino group is orientated to the same side of the mol­ecule], to a first approximation, the mol­ecule has a stunted T-shape. The cyclo­hexene ring adopts a half-chair conformation with the methyl­ene C atom connected to the dihydro­pyrazole ring lying 0.665 (4) Å out of the plane of the five remaining atoms (r.m.s. deviation = 0.050 Å). The components of the asymmetric unit are connected by an O—H⋯O hydrogen bond. Further links between mol­ecules leading to a three-dimensional architecture are of the type N—H⋯O.

In the title compound, C11H8N2O2S, there is a twist in the mol­ecule, with the dihedral angle between the five- and six-membered rings being 31.77 (9)°. The nitro group is slightly twisted out of the plane of the benzene ring to which it is attached [O—N—C—C torsion angle = 9.0 (3)°]. The S and N atoms are syn. In the crystal, supra­molecular layers parallel to (-204) are formed by C—H⋯O and C—H⋯N inter­actions. These layers are connected into a three-dimensional architecture by π–π inter­actions occurring between centrosymmetrically related benzene rings [centroid–centroid distance = 3.6020 (11) Å].

In the title compound, C22H18F6N2O2, the five atoms comprising each O=C—C=C—N fragment are almost coplanar (the r.m.s. deviation for the fitted atoms being 0.008 and 0.002 Å) and form a dihedral angle of 47.70 (12)°. The phenyl ring attached to each of the O=C—C=C—N fragments is twisted out of the respective plane with dihedral angles of 64.46 (11) and 61.82 (10)°, respectively. An almost orthogonal relationship for the phenyl rings is indicated by the dihedral angle between them of 78.19 (14)°. The conformation about each ethyl­ene bond is Z, which allows for the formation of intra­molecular N—H⋯O hydrogen bonds which close S(6) loops. The most prominent feature of the crystal packing are N—H⋯O hydrogen bonds that result in supra­molecular chains along the a axis. The F atoms of one –CF3 groups are disordered over three sets of sites with site-occupation factors of 0.318 (4), 0.360 (10) and 0.322 (9).

In the title compound, C15H14N2OS, the pyridinone ring in the fused-ring system is nearly planar (r.m.s. deviation = 0.011 Å) and the cyclo­hexene ring has a twisted half-boat conformation with the methyl­ene C atom adjacent to the methine C atom deviating by 0.592 (7) Å from the plane defined by the remaining five atoms (r.m.s. deviation = 0.108 Å). The thienyl ring is disordered over two almost coplanar positions of opposite orientation in a 0.649 (4):0.351 (4) ratio, and forms dihedral angles of 51.4 (3) (major component) and 54.2 (3)°, respectively, with the pyridinone ring. In the crystal, inversion-related mol­ecules associate via an eight-membered {⋯HNCO}2 synthon and these are linked into a linear supra­molecular chain along the a axis by weak π–π inter­actions that occur between centrosymmetrically related pyridinone rings [centroid–centroid distance = 3.889 (2) Å].

In the title compound, C15H12OS, the cyclo­hexene ring has a twisted boat conformation with the C atom between the ketone and methyl­ene atom and this methyl­ene C atom lying 0.280 (3) and 0.760 (3) Å, respectively, from the plane through the remaining four atoms (r.m.s. deviation = 0.004 Å). The dihedral angle between the benzene and thio­phene rings [21.64 (9)°] indicates an overall twist in the mol­ecule. The thio­phene S and ketone O atoms are anti, an orientation that allows the close approach of these atoms [3.3116 (17) Å] in the crystal structure and which leads to the formation of helical supra­molecular chains along the c axis.

The heterocyclic ring in the title compound, C10H7F3O3, has a half-boat conformation with the hy­droxy-bearing C atom lying 0.595 (3) Å out of the plane of the five remaining atoms (r.m.s. deviation = 0.022 Å) in the direction of the hy­droxy O atom. Linear supra­molecular chains along the a axis, sustained by O—H⋯O hydrogen bonds between the hy­droxy H and ketone O atoms, feature in the crystal packing. These chains are connected into a three-dimensional architecture by C—H⋯O and C—H⋯F contacts.

Two independent mol­ecules (A and B) comprise the asymmetric unit of the title compound, C18H16O2. Mol­ecule B is virtually superimposable upon A. Minor differences are noted in the dihedral angles between the terminal benzene rings of 56.03 (10) and 54.62 (10)°, and in the orientations of meth­oxy groups with respect to the benzene rings to which they are attached [C—O—C—C torsion angles = 169.11 (19) and −172.37 (18)°]. The cyclo­hexene ring of each fused ring system has a screw-boat conformation. In the crystal, C—H⋯π inter­actions assemble mol­ecules into a supra­molecular array in the ab plane.

In the title indolin-2-one derivative, C15H11NO, the phenyl ring and the oxoindoline fused-ring system (r.m.s. deviation = 0.011 Å) are aligned at 48.52 (6)°. In the crystal, inversion-related mol­ecules form an N—H⋯O hydrogen-bonded dimer via an eight-membered {⋯HNCO}2 synthon. The dimeric aggregates are linked into a three-dimensional architecture via C—H⋯O and π–π inter­actions between the five- and six-membered rings of the fused ring system, with an inter-centroid distance of 3.4538 (8) Å.

In the title compound, C14H17NO5S, the thia­zine ring adopts a half-chair conformation. The mol­ecule exhibits an intra­molecular O—H⋯O hydrogen bond, which forms a six-membered S(6) ring motif. The planes of the benzene and thia­zine rings are inclined at a dihedral angle of 15.30 (12)°.

The title mol­ecule, C11H15N3O2S, features a five-membered ring which is twisted about the middle CH2—CH2 bond. The benzene ring is inclined with respect to the imine residue [C—N—N—C torsion angle = 165.4 (2)°]. Supra­molecular layers in the bc plane are formed by hydrogen bonds between the amine H atoms and sulfonamide O and imine N atoms, as well as by a weak hydrazine H-atom inter­molecular inter­action with the second sulfonamide O atom.