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1.  Overview of the CCP4 suite and current developments 
An overview of the CCP4 software suite for macromolecular crystallography is given.
The CCP4 (Collaborative Computational Project, Number 4) software suite is a collection of programs and associated data and software libraries which can be used for macromolecular structure determination by X-ray crystallography. The suite is designed to be flexible, allowing users a number of methods of achieving their aims. The programs are from a wide variety of sources but are connected by a common infrastructure provided by standard file formats, data objects and graphical interfaces. Structure solution by macromolecular crystallo­graphy is becoming increasingly automated and the CCP4 suite includes several automation pipelines. After giving a brief description of the evolution of CCP4 over the last 30 years, an overview of the current suite is given. While detailed descriptions are given in the accompanying articles, here it is shown how the individual programs contribute to a complete software package.
doi:10.1107/S0907444910045749
PMCID: PMC3069738  PMID: 21460441
CCP4; macromolecular crystallography; software; collaboration; automation; macromolecular structure determination
2.  An introduction to molecular replacement 
An outline is given of the basic features of the molecular-replacement method for solving crystal structures.
Molecular replacement is fundamentally a simple trial-and-error method of solving crystal structures when a suitable related model is available. The underlying simplicity of the method is often obscured by the mathematical trickery required to make the searches computationally tractable. This introduction sketches the essential issues in molecular replacement without going into technical details. General search strategies are discussed and the alternative Patterson and likelihood approaches are outlined.
doi:10.1107/S0907444907051554
PMCID: PMC2394790  PMID: 18094461
molecular replacement; rotation function; translation function; maximum likelihood

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