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1.  Four differently substituted 2-aryl-2,3,4,5-tetra­hydro-1H-1,4-ep­oxy-1-benzazepines: hydrogen-bonded structures in one, two and three dimensions 
In (2RS,4SR)-7-chloro-2-exo-(2-chloro-6-fluoro­phen­yl)-2,3,4,5-tetra­hydro-1H-1,4-epoxy-1-benzazepine, C16H12Cl2FNO, (I), mol­ecules are linked into chains by a single C—H⋯π(arene) hydrogen bond. (2RS,4SR)-2-exo-(2-Chloro-6-fluoro­phen­yl)-2,3,4,5-tetra­hydro-1H-1,4-ep­oxy-1-benzazepine, C16H13ClFNO, (II), is isomorphous with compound (I) but not strictly isostructural with it, as the hydrogen-bonded chains in (II) are linked into sheets by an aromatic π–π stacking inter­action. The mol­ecules of (2RS,4SR)-7-methyl-2-exo-(4-methyl­phenyl)-2,3,4,5-tetra­hydro-1H-1,4-ep­oxy-1-benzazepine, C18H19NO, (III), are linked into sheets by a combination of C—H⋯N and C—H⋯π(arene) hydrogen bonds. (2S,4R)-2-exo-(2-Chloro­phen­yl)-2,3,4,5-tetra­hydro-1H-1,4-ep­oxy-1-benzazepine, C16H14ClNO, (IV), crystallizes as a single enantiomer and the mol­ecules are linked into a three-dimensional framework structure by a combination of one C—H⋯O hydrogen bond and three C—H⋯π(arene) hydrogen bonds.
PMCID: PMC2737425  PMID: 19726863
2.  Sterically shielded pyramidal amino groups in two 4,4′-(aryl­methyl­ene)bis­(6-allyl-3-chloro-2-methyl­aniline) derivatives 
4,4′-(Phenyl­methyl­ene)bis­(6-allyl-3-chloro-2-methyl­aniline), C27H28Cl2N2, (I), and 4,4′-(2-thienylmethyl­ene)bis­(6-allyl-3-chloro-2-methyl­aniline), C25H26Cl2N2S, (II), adopt similar mol­ecular conformations, although the thienyl group in (II) exhibits orientational disorder over two sets of sites with occupancies of 0.614 (3) and 0.386 (3). The amino groups in both compounds are pyramidal. A single N—H⋯N hydrogen bond links the mol­ecules of (I) into cyclic centrosymmetric dimers. Mol­ecules of (II) are linked by an ordered C—H⋯π(arene) hydrogen bond to form cyclic centrosymmetric dimers, and these dimers are linked into statistically inter­rupted chains by a second C—H⋯π(arene) hydrogen bond involving a donor in the minor component of the disordered thienyl unit.
PMCID: PMC2737426  PMID: 19726866
3.  Different hydrogen-bonded structures in three 2-thienyl-substituted tetra­hydro-1,4-ep­oxy-1-benzazepines 
The mol­ecules of (2RS,4SR)-2-exo-(5-bromo-2-thienyl)-7-chloro-2,3,4,5-tetra­hydro-1H-1,4-ep­oxy-1-benzazepine, C14H11BrClNOS, (I), are linked into cyclic centrosymmetric dimers by C—H⋯π(thienyl) hydrogen bonds. Each such dimer makes rather short Br⋯Br contacts with two other dimers. In (2RS,4SR)-2-exo-(5-methyl-2-thienyl)-2,3,4,5-tetra­hydro-1H-1,4-ep­oxy-1-benzazepine, C15H15NOS, (II), a com­bination of C—H⋯O and C—H⋯π(thienyl) hydrogen bonds links the mol­ecules into chains of rings. A more complex chain of rings is formed in (2RS,4SR)-7-chloro-2-exo-(5-methyl-2-thienyl)-2,3,4,5-tetra­hydro-1H-1,4-ep­oxy-1-benzazepine, C15H14ClNOS, (III), built from a combination of two independent C—H⋯O hydrogen bonds, one C—H⋯π(arene) hydrogen bond and one C—H⋯π(thienyl) hydro­gen bond.
PMCID: PMC2737428  PMID: 19726868

Results 1-3 (3)