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issn:1757-594
1.  Conformational changes in receptor tyrosine kinase signaling: an ErbB garden of delights 
F1000 biology reports  2009;1(72):1-4.
The ErbB family of receptor tyrosine kinases plays important roles in cell proliferation, differentiation, and apoptosis. Recent structural studies of these receptors have demonstrated dramatic conformational effects that are critical to their ligand binding and activation, and have shown that these receptors provide levels of control beyond the classic dimerization/activation mechanism. These results indicate that this class of receptors has evolved subtle regulatory mechanisms via genetic and protein structural changes to influence their effects on cell behaviors.
doi:10.3410/B1-72
PMCID: PMC2847299  PMID: 20357902
2.  Conformational changes in receptor tyrosine kinase signaling: an ErbB garden of delights 
The ErbB family of receptor tyrosine kinases plays important roles in cell proliferation, differentiation, and apoptosis. Recent structural studies of these receptors have demonstrated dramatic conformational effects that are critical to their ligand binding and activation, and have shown that these receptors provide levels of control beyond the classic dimerization/activation mechanism. These results indicate that this class of receptors has evolved subtle regulatory mechanisms via genetic and protein structural changes to influence their effects on cell behaviors.
doi:10.3410/B1-72
PMCID: PMC2847299  PMID: 20357902

Results 1-2 (2)