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1.  Dual-isotope Acquisition for CT–SPECT Registration of Infection Studies 
Journal of Digital Imaging  2009;23(3):258-267.
The registration of CT and NM images can enhance patient diagnosis since it allows for the fusion of anatomical and functional information as well as attenuation correction of NM images. However, irrespective of the methods used, registration accuracy depends heavily on the characteristics of the input images and the degree of similarity between them. This poses a challenge for registering CT and NM images as they may have very different characteristics. To address the particular problem of CT and In-111 SPECT registration, we propose to perform a dual-isotope study which involves an additional injection of Tc-99m MDP to generate two inherently registered images: In-111 SPECT and Tc-99m SPECT. As skeletal structures are visible in both CT and Tc-99m SPECT, performing registration of these images may be much more effective. The very same spatial transformation derived can be immediately applied to complete the registration of CT and the corresponding In-111 SPECT. Accordingly, we hypothesize that the registration of CT and Tc-99m SPECT can be more accurately performed than the registration of CT and In-111 SPECT and seek to compare the accuracies between the aforementioned registrations. In this paper, we have collected three clinical datasets, with the ground-truth transformations known, and tested the proposed approach by using a mutual information-based algorithm to solve for the rigid/non-rigid misalignments introduced to them. Based on the results of our experiments, we conclude that registration using Tc-99m SPECT can achieve 100% success rate, and is thus much more superior to the registration using In-111 SPECT, which at best, achieves only 38% success rate. Clearly, the introduction of a dual-isotope acquisition can substantially improve the registration of SPECT and CT images.
PMCID: PMC3046655  PMID: 19137374
3D imaging (imaging; three-dimensional); image fusion; image processing; image registration; computed tomography; nuclear medicine; single photon emission computed tomography (SPECT); simulation; graphical user interface (GUI)
2.  Development of NEMA-based Software for Gamma Camera Quality Control 
Journal of Digital Imaging  2007;21(2):243-255.
We have developed a cross-platform software application that implements all of the basic standardized nuclear medicine scintillation camera quality control analyses, thus serving as an independent complement to camera manufacturers’ software. Our application allows direct comparison of data and statistics from different cameras through its ability to uniformly analyze a range of file types. The program has been tested using multiple gamma cameras, and its results agree with comparable analysis by the manufacturers’ software.
PMCID: PMC3043858  PMID: 17393254
Nuclear medicine; quality control; single-photon emission computed tomography (SPECT); performance measurement; image quality analysis
3.  3D Bicipital Groove Shape Analysis and Relationship to Tendopathy 
Journal of Digital Imaging  2007;21(2):219-234.
The bicipital groove of the proximal humerus is formed by the medial and lateral tuberosities and serves to retain the long biceps tendon in its proper place as the arm moves. Bicipital root and proximal tendon disorders are an important symptom generator in the shoulder. The accuracy of the diagnosis of many shoulder disorders visually without quantitative shape analysis is limited, motivating a clinical need for some ancillary method to assess the proximal biceps. In previous studies, measurements of bicipital groove shape were 2-dimensional (2D), taken from a single axial slice. Because of significant variations in groove shape from one axial slice to another in a single patient, such approaches risk overlooking shape features important to long biceps tendon pathology. In this paper, we present a study of the relationship between bicipital groove shape and long biceps tendon pathology using a novel 3-dimensional (3D) shape descriptor for the bicipital groove. In addition to providing quantitative measures of the shape of the groove and its relation to tendopathy, the new descriptor allows for intuitive, descriptive visualization of the shape of the groove.
PMCID: PMC3043862  PMID: 17342555
Bicipital groove; intertubercular sulcus; long biceps tendon; musculoskeletal disorder; 3D shape analysis

Results 1-3 (3)