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1.  Dynamic gene expression of Lin-28 during embryonic development in mouse and chicken 
Gene expression patterns : GEP  2007;8(3):155-160.
The Caenorhabditis elegans heterochronic gene lin-28 regulates developmental timing in the nematode trunk. We report the dynamic expression patterns of Lin-28 homologues in mouse and chick embryos. Whole mount in situ hybridization revealed specific and intriguing expression patterns of Lin-28 in the developing mouse and chick limb bud. Mouse Lin-28 expression was detected in both the fore-limb and hindlimb at E9.5, but disappeared from the forelimb at E10.5, and finally from the forelimb and hindlimb at E11.5. Chicken Lin-28, which was first detected in the limb primordium at stage 15/16, was also downregulated as the stage proceeded. The amino acid sequences of mouse and chicken Lin-28 genes are highly conserved and the similar expression patterns of Lin-28 during limb development in mouse and chicken suggest that this heterochronic gene is also conserved during vertebrate limb development.
PMCID: PMC2262948  PMID: 18077221
Heterochronic gene; Whole mount in situ hybridization; Mouse; Chick; Limb bud; Lin-28; MicroRNAs; Developmental timing; Dynamic expression; Embryo

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