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1.  Finding common susceptibility variants for complex disease: past, present and future 
The identification of complex disease susceptibility loci has been accelerated considerably by advances in high-throughput genotyping technologies, improved insight into correlation patterns of common variants and the availability of large-scale sample sets. Linkage scans and small-scale candidate gene studies have now given way to genome-wide association scans. In this review, we summarize insights gained from the past, highlight practical issues relating to the design and analysis of current state-of-the-art GWA studies and look into future trends in the field of human complex trait genetics.
doi:10.1093/bfgp/elp020
PMCID: PMC2758134  PMID: 19571035
association study; complex disease; single nucleotide polymorphism; genome-wide association scan; meta-analysis; sequencing

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