Objective: The purpose of this study was to investigate the efficacy of 200 mg of prophylactic
doxycycline in preventing pelvic infection after curettage for spontaneous (incomplete) abortion.
Methods: A randomized, prospective, double-blinded study was carried out involving 300 women
with an incomplete abortion who were given either placebo or 200 mg of doxycycline orally 30–60
min prior to curettage. A hematocrit, WBC count, pregnancy test, syphilis serology, Neisseria
gonorrhoeae culture, and Micro Trak (monoclonal antibody test, Syba, San Jose, CA) for Chlamydia
trachomatis were performed. The patients were scheduled for follow-up 2 weeks later. Antibiotic
administration for any reason as well as the postoperative infection rate in these women was
Results: Eleven women were excluded from analysis, leaving 289 evaluable. N. gonorrhoeae was
isolated from 6 (2%) women and C. trachomatis from 8 (3%) women, and the syphilis serology was
serofast in 4 (1%) women. Endometritis complicated the procedure in 4 women who received
placebo and in 1 woman who received doxycycline (P = 0.22).
Conclusion: Prophylactic doxycycline is not effective in preventing pelvic infection after curettage
for spontaneous (incomplete) abortion.