Objective: This prospective study was undertaken to examine the effects of subclinical intraamniotic
infection on fetal behavioral patterns.
Methods: Amniotic fluid was obtained from four groups of patients (n = 99): group 1, patients
with preterm premature rupture of the fetal membranes (PPROM) without infection; group 2,
patients with PPROM and infection; group 3, patients with preterm labor (PTL) and without
infection; and group 4, patients with PTL and infection. Fetal biophysical profiles were obtained on
admission to the labor suite. Amniotic fluid was analyzed for the presence of microorganisms and
endotoxin to confirm intraamniotic infection; cytokines interleukin (IL)-1β, IL-6, and IL-8 were
Results: We found no association between low scores for biophysical parameters and subclinical
infection in patients with PPROM or PTL.
Conclusions: We could not demonstrate that upon a patient's admission to the labor hall absent
fetal breathing and absent fetal movement, as well as reactivity, correlate with subclinical intraamniotic
infection. Elevated cytokines, i.e. IL-1β, IL-6, and IL-8 were associated with subclinical