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1.  Precision Medicine Clinical Trials: Defining New Treatment Strategies 
Seminars in oncology nursing  2014;30(2):109-116.
Objectives
To discuss the role of clinical trials in the changing landscape of cancer care resulting in individualized cancer treatment plans including a discussion of several innovative randomized studies designed to evaluate multiple targeted therapies in molecularly defined subsets of individuals.
Data Sources
Medical and nursing literature, research articles, and clinicaltrials.gov.
Conclusion
Recent advancements in cancer biomarkers and biomedical technology have begun to transform fundamentals of cancer therapeutics and clinical trials through innovative adaptive trial designs. The goal of these studies is to learn not only if a drug is safe and effective but also how it is best delivered and who will derive the most benefit.
Implications for Nursing Practice
Implementation of clinical trials in the cancer biomarker era requires knowledge, skills, and expertise related to the use of biomarkers and molecularly defined processes underlying a malignancy, as well as an understanding of associated ethical, legal, and social issues to provide competent, safe, and effective health care and patient communication.
doi:10.1016/j.soncn.2014.03.004
PMCID: PMC4280791  PMID: 24794084
Precision medicine; Clinical trial; Adaptive design; Biomarker; Molecular targets; Research ethics
2.  Lung Cancer Screening: Promise and Pitfalls 
Seminars in oncology nursing  2008;24(1):9-15.
OBJECTIVES
To provide an overview of the status of lung cancer screening.
DATA SOURCES
Published articles, book chapters, websites, and research studies on lung cancer screening.
CONCLUSION
Screening with chest x-ray and sputum cytology has not been shown to be effective in reducing lung cancer mortality. Although screening with helical CT is currently under investigation in randomized clinical trials, observational studies have not shown evidence that it can detect lung cancer that is curable.
IMPLICATION FOR NURSING PRACTICE
As healthcare educators and caregivers, nurses should be informed of the status and current controversies associated with lung cancer screening.
doi:10.1016/j.soncn.2007.11.007
PMCID: PMC2266834  PMID: 18222147
lung cancer screening; helical CT; low-dose CT; spiral CT; cancer screening clinical trials

Results 1-2 (2)