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1.  Relaxin Signaling in Uterine Fibroids 
Uterine fibroid is the most common tumor of female reproductive organs. The role of relaxin signaling in leiomyoma development was analyzed. We used 23 matched pairs of leiomyoma and normal myometrium samples to compare the expression of relaxin family peptide receptors RXFP1, RXFP2, caveolin 1, desmin, steroid receptors and their co-factors NCOR1 and NCOR2. The expression of RXFP1 evaluated by quantitative RT-PCR was down-regulated in fibroid tissues. Relaxin or INSL3 treatment suppressed TGF-╬▓ induced phosphorylation of SMAD2 in rat leiomyoma ELT-3 cells in vitro suggesting a possible involvement of relaxins in etiology of leiomyoma.
PMCID: PMC2954601  PMID: 19416222
leiomyoma; transforming growth factor; relaxin; INSL3; phospho-SMAD2
2.  Relaxin/RXFP1 Signaling in Prostate Cancer Progression 
We have shown that relaxin peptide expression was significantly elevated in recurrent human prostate cancer. Stimulation with relaxin increased migration, invasiveness, proliferation, and adhesion of LNCaP and PC3 cells in vitro. Opposite effects on cellular phenotype were observed after suppression of endogenous relaxin/RXFP1 expression or signaling. We showed an accelerated progression of prostate cancer in TRAMP males with transgenic relaxin overexpression and a longer survival of TRAMP, RXFP1-deficient males. Suppression of RXFP1 expression in PC3 xenografts in nude mice using siRNA intratumoral injections resulted in decrease of tumor size, cell proliferation, and metastasis rate.
PMCID: PMC2945500  PMID: 19416223
Prostate cancer; Relaxin; RXFP1; siRNA; TRAMP

Results 1-2 (2)