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1.  ABSENCE OF CARDIAC TOXICITY OF ZIDOVUDINE IN INFANTS 
Background
Some evidence suggests that perinatal exposure to zidovudine may cause cardiac abnormalities in infants. We prospectively studied left ventricular structure and function in infants born to mothers infected with the human immunodeficiency virus (HIV) in order to determine whether there was evidence of zidovudine cardiac toxicity after perinatal exposure.
Methods
We followed a group of infants born to HIV-infected women from birth to five years of age with echocardiographic studies every four to six months. Serial echocardiograms were obtained for 382 infants without HIV infection (36 with zidovudine exposure) and 58 HIV-infected infants (12 with zidovudine exposure). Repeated-measures analysis was used to examine four measures of left ventricular structure and function during the first 14 months of life in relation to zidovudine exposure.
Results
Zidovudine exposure was not associated with significant abnormalities in mean left ventricular fractional shortening, end-diastolic dimension, contractility, or mass in either non–HIV-infected or HIV-infected infants. Among infants without HIV infection, the mean fractional shortening at 10 to 14 months was 38.1 percent for those never exposed to zidovudine and 39.0 percent for those exposed to zidovudine (mean difference, −0.9 percentage point; 95 percent confidence interval, −3.1 to 1.3 percentage points; P=0.43). Among HIV-infected infants, the mean fractional shortening at 10 to 14 months was similar in those never exposed to zidovudine (35.4 percent) and those exposed to the drug (35.3 percent) (mean difference, 0.1 percentage point; 95 percent confidence interval, −3.7 to 3.9 percentage points; P=0.95). Zidovudine exposure was not significantly related to depressed fractional shortening (shortening of 25 percent or less) during the first 14 months of life. No child over the age of 10 months had depressed fractional shortening.
Conclusions
Zidovudine was not associated with acute or chronic abnormalities in left ventricular structure or function in infants exposed to the drug in the perinatal period.
doi:10.1056/NEJM200102083440613
PMCID: PMC4280909  PMID: 11221608
2.  Vitamin D–Binding Protein and Vitamin D in Blacks and Whites 
The New England journal of medicine  2014;370(9):879-880.
doi:10.1056/NEJMc1315850#SA4
PMCID: PMC4165606  PMID: 24571766
3.  Idelalisib — A PI3Kδ Inhibitor for B-Cell Cancers 
The New England journal of medicine  2014;370(11):1061-1062.
doi:10.1056/NEJMe1400055
PMCID: PMC4088325  PMID: 24620870
4.  P2Y12 Inhibition in Non ST-Elevation MI: Can Later Be Better? 
The New England journal of medicine  2013;369(11):10.1056/NEJMe1308820.
doi:10.1056/NEJMe1308820
PMCID: PMC3872834  PMID: 23991623
5.  The Many Causes of Severe Congenital Neutropenia 
doi:10.1056/NEJMp0806821
PMCID: PMC4162527  PMID: 19118300
6.  Fibulin-3 as a Biomarker for Pleural Mesothelioma 
doi:10.1056/NEJMc1213514
PMCID: PMC4155494  PMID: 23301743
7.  Islet Transplantation as a Treatment for Diabetes 
doi:10.1056/NEJM200405133502022
PMCID: PMC4152959  PMID: 15141057
8.  Diabetes Treatment — Bridging the Divide 
The New England journal of medicine  2007;356(15):1499-1501.
doi:10.1056/NEJMp078030
PMCID: PMC4152979  PMID: 17429082
9.  Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects 
The New England journal of medicine  2009;361(2):152-160.
BACKGROUND
A previous report described the presence of autoantibodies against folate receptors in 75% of serum samples from women with a history of pregnancy complicated by a neural-tube defect, as compared with 10% of controls. We sought to confirm this finding in an Irish population, which traditionally has had a high prevalence of neuraltube defects.
METHODS
We performed two studies. Study 1 consisted of analysis of stored frozen blood samples collected from 1993 through 1994 from 103 mothers with a history of pregnancy complicated by a neural-tube defect (case mothers), 103 mothers with a history of pregnancy but no complication by a neural-tube defect (matched with regard to number of pregnancies and sampling dates), 58 women who had never been pregnant, and 36 men. Study 2, conducted to confirm that the storage of samples did not influence the folate-receptor autoantibodies, included fresh samples from 37 case mothers, 22 control mothers, 10 women who had never been pregnant, and 9 men. All samples were assayed for blocking and binding autoantibodies against folate receptors.
RESULTS
In Study 1, blocking autoantibodies were found in 17% of case mothers, as compared with 13% of control mothers (odds ratio, 1.54; 95% confidence interval [CI], 0.70 to 3.39), and binding autoantibodies in 29%, as compared with 32%, respectively (odds ratio, 0.82; 95% CI, 0.44 to 1.50). Study 2 showed similar results, indicating that sample degradation was unlikely.
CONCLUSIONS
The presence and titer of maternal folate-receptor autoantibodies were not significantly associated with a neural-tube defect–affected pregnancy in this Irish population.
doi:10.1056/NEJMoa0803783
PMCID: PMC4149290  PMID: 19587340
10.  Genotype-Guided Dosing of Vitamin K Antagonists 
The New England journal of medicine  2014;370(18):1762-1763.
doi:10.1056/NEJMc1402521#SA4
PMCID: PMC4145721  PMID: 24785217
11.  High-Frequency Oscillatory Ventilation on Shaky Ground 
The New England journal of medicine  2013;368(9):863-865.
doi:10.1056/NEJMe1300103
PMCID: PMC4142426  PMID: 23339640
13.  Genetics, Epigenetics and Leukemia 
The New England journal of medicine  2010;363(25):2460-2461.
doi:10.1056/NEJMe1012071
PMCID: PMC4117480  PMID: 21067376
14.  Effects of an Estrogen Receptor α Variant 
The New England journal of medicine  2013;369(17):1663-1664.
doi:10.1056/NEJMc1310364#SA1
PMCID: PMC4103179  PMID: 24152274
15.  Hypoglossal-Nerve Stimulation for Obstructive Sleep Apnea 
The New England journal of medicine  2014;370(2):170-171.
doi:10.1056/NEJMe1314084
PMCID: PMC3995813  PMID: 24401056
16.  Percutaneous Repair or Surgery for Mitral Regurgitation 
doi:10.1056/NEJMc1105564#SA2
PMCID: PMC4071614  PMID: 21732843
17.  Immune Evasion by Chimeric Trachea 
The New England journal of medicine  2010;362(2):172-174.
doi:10.1056/NEJMe0908366
PMCID: PMC4045014  PMID: 20071709
18.  TREM2 and Neurodegenerative Disease 
The New England journal of medicine  2013;369(16):1564-1565.
doi:10.1056/NEJMc1306509#SA1
PMCID: PMC3980568  PMID: 24131184
19.  Weighing the Benefits and Burdens of Witnessed Resuscitation 
The New England journal of medicine  2013;368(11):1058-1059.
doi:10.1056/NEJMe1300397
PMCID: PMC3601383  PMID: 23484835
20.  Increasing Options for the Treatment of Osteoporosis 
The New England journal of medicine  2009;361(8):818-820.
doi:10.1056/NEJMe0905480
PMCID: PMC3901579  PMID: 19671654
21.  Current and Future Therapies for Hepatitis C Virus Infection 
The New England journal of medicine  2013;369(7):10.1056/NEJMc1307589.
doi:10.1056/NEJMc1307589
PMCID: PMC3878654  PMID: 23944318
22.  Diagnosis of Smoldering Multiple Myeloma 
The New England journal of medicine  2011;365(5):474-475.
doi:10.1056/NEJMc1106428
PMCID: PMC3773467  PMID: 21812699
23.  The Tumor Lysis Syndrome 
The New England journal of medicine  2011;365(6):571-574.
doi:10.1056/NEJMc1106641#SA1
PMCID: PMC3740722  PMID: 21830982
24.  The spindle assembly checkpoint, aneuploidy and gastrointestinal cancer 
The New England journal of medicine  2010;363(27):2665-2666.
doi:10.1056/NEJMe1008017
PMCID: PMC3731131  PMID: 21190461
25.  PARP and Cancer — If It's Broke, Don't Fix It 
The New England journal of medicine  2011;364(3):277-279.
doi:10.1056/NEJMe1012546
PMCID: PMC3712751  PMID: 21208102

Results 1-25 (45)