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1.  Kwashiorkor. 
BMJ : British Medical Journal  1990;301(6763):1276.
PMCID: PMC1664404  PMID: 2136181
3.  Recognising failure to thrive in early childhood. 
Archives of Disease in Childhood  1990;65(11):1263-1265.
The maximum weight centile achieved by a child between 4 and 8 weeks of age was found to be a better predictor of the centile at 12 months than the birth weight centile. Children whose weight deviated two or more major centiles below this maximum weight centile for a month or more showed significant anthropometric differences during the second year of life from those who showed no such deviation. It is suggested that this leads to a logical and practical definition of failure to thrive.
PMCID: PMC1792592  PMID: 2131802
4.  Screening children from overseas for infections: is it justified? 
BMJ : British Medical Journal  1990;301(6755):800-802.
OBJECTIVES--To investigate current practice of screening children from abroad for infections after coming to the United Kingdom, and to make recommendations for future practice. DESIGN--A review of literature and a questionnaire sent to all health authorities and boards in the United Kingdom. SETTING--All health authorities and boards in the United Kingdom. SUBJECTS--167 Health authorities or boards that completed questionnaires (response rate 80%), 59 of which used a screening programme. MAIN OUTCOME MEASURE--Response to questionnaire on policies for screening children for infections on their return from overseas. RESULTS--12 Of the 59 authorities screened all children and one screened only those from the West Indian subcontinent. 13 Authorities excluded children from school while awaiting results; 58 screened for tuberculosis and four for diphtheria. CONCLUSIONS--There is a wide variation in screening policies around the country with no national consensus. Screening for diphtheria, typhoid, and salmonellosis is hard to justify and is probably not effective. Screening for tuberculosis, however, is supported by many authorities, is widely practised, and probably is effective. There is a strong case for rationalisation of screening.
PMCID: PMC1663906  PMID: 2224270
6.  Auditing community screening for undescended testes. 
Archives of Disease in Childhood  1990;65(8):888-890.
Different ways of auditing screening for undescended testes, using Hospital Activity Analysis data, hospital case notes, and community/general practice records are described. The cumulative orchidopexy rate per 1000 male births in successive birth cohorts is a simple tool for monitoring trends within a health district. Information gained from community/general practice records is valuable in highlighting problem areas in screening, such as the lack of clear diagnostic criteria and referral pathways.
PMCID: PMC1792507  PMID: 1976004
9.  Feasibility of percutaneous transluminal angioplasty for carotid artery stenosis. 
Percutaneous transluminal balloon angioplasty was attempted in seven patients with internal carotid artery stenosis, including one patient who had two procedures. All had recurrent, carotid territory, neurological symptoms considered haemodynamic in origin. Six had occlusion of the contralateral internal carotid artery. Cerebral blood flow studies confirmed diminished cerebrovascular reserve in six patients studied. In five patients (six procedures) angioplasty of the stenosed internal carotid artery was carried out successfully. With two patients technical difficulty in crossing the stenosis prevented angioplasty and in one patient with bilateral stenosis the procedure was not attempted on the second side because of the severity of the stenosis. In two patients transient aphasia developed during cannulation of the carotid artery and in another a transient monoparesis developed during the procedure. Both these haemodynamic complications recovered within ten minutes. No other complications occurred. Our experience suggests that balloon angioplasty is technically feasible in the management of stenotic carotid disease associated with haemodynamic stroke. It is a technically simple procedure requiring only a brief admission to hospital. However, its general application to patients with thromboembolic carotid-territory stroke will depend on the risk/benefit ratio compared to carotid endarterectomy or to conventional medical treatment.
PMCID: PMC1014136  PMID: 2139110
11.  Vectors for low copy transformation of C. elegans. 
Nucleic Acids Research  1990;18(14):4269-4270.
PMCID: PMC331209  PMID: 2377476
12.  Use of repetitive DNA probes as physical mapping strategy in Caenorhabditis elegans. 
Nucleic Acids Research  1990;18(17):5077-5081.
A method for linking genomic sequences cloned in yeast artificial chromosomes (YACs) has been tested using Caenorhabditis elegans as a model system. Yeast clones carrying YACs with repeated sequences were selected from a C. elegans genomic library, total DNA was digested with restriction enzymes, transferred to nylon membranes and probed with a variety of repetitive DNA probes. YAC clones that overlap share common bands with one or more repetitive DNA probes. In 159 YAC clones tested with one restriction enzyme and six probes 28 overlapping clones were detected. The advantages and limitations of this method for construction of YAC physical maps is discussed.
PMCID: PMC332126  PMID: 2402436

Results 1-12 (12)